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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Interactions between G-protein- coupled receptors and periplakin: a selective means to regulate G-protein activation.

A substantial number of G-protein-coupled receptor-interacting proteins have been identified initially by the use of yeast two-hybrid screens. Using the C-terminal tail of both opioid receptors and the melanin concentrating hormone receptor-1 as bait, the actin and intermediate filament- binding protein periplakin was isolated. In each case, the site of interaction is within helix VIII of the receptor and periplakin limits agonist- mediated G-protein activation potentially by competing with G-protein for this region of the receptor.[1]

References

  1. Interactions between G-protein-coupled receptors and periplakin: a selective means to regulate G-protein activation. Milligan, G., Murdoch, H., Kellett, E., White, J.H., Feng, G.J. Biochem. Soc. Trans. (2004) [Pubmed]
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