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Gene Review

GPR1  -  G protein-coupled receptor 1

Homo sapiens

Synonyms: G-protein coupled receptor 1
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Disease relevance of GPR1


Psychiatry related information on GPR1


High impact information on GPR1


Chemical compound and disease context of GPR1


Biological context of GPR1


Anatomical context of GPR1


Associations of GPR1 with chemical compounds


Physical interactions of GPR1


Enzymatic interactions of GPR1


Regulatory relationships of GPR1


Other interactions of GPR1


Analytical, diagnostic and therapeutic context of GPR1


  1. The synthetic peptide derived from the NH2-terminal extracellular region of an orphan G protein-coupled receptor, GPR1, preferentially inhibits infection of X4 HIV-1. Jinno-Oue, A., Shimizu, N., Soda, Y., Tanaka, A., Ohtsuki, T., Kurosaki, D., Suzuki, Y., Hoshino, H. J. Biol. Chem. (2005) [Pubmed]
  2. An orphan G protein-coupled receptor, GPR1, acts as a coreceptor to allow replication of human immunodeficiency virus types 1 and 2 in brain-derived cells. Shimizu, N., Soda, Y., Kanbe, K., Liu, H.Y., Jinno, A., Kitamura, T., Hoshino, H. J. Virol. (1999) [Pubmed]
  3. G protein-coupled receptors in HIV and SIV entry: new perspectives on lentivirus-host interactions and on the utility of animal models. Unutmaz, D., KewalRamani, V.N., Littman, D.R. Semin. Immunol. (1998) [Pubmed]
  4. HIV-specific T cell cytotoxicity mediated by RANTES via the chemokine receptor CCR3. Hadida, F., Vieillard, V., Autran, B., Clark-Lewis, I., Baggiolini, M., Debré, P. J. Exp. Med. (1998) [Pubmed]
  5. Transducin interactions with rhodopsin. Evidence for positive cooperative behavior. Wessling-Resnick, M., Johnson, G.L. J. Biol. Chem. (1987) [Pubmed]
  6. Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor. Thomson, P.A., Wray, N.R., Thomson, A.M., Dunbar, D.R., Grassie, M.A., Condie, A., Walker, M.T., Smith, D.J., Pulford, D.J., Muir, W., Blackwood, D.H., Porteous, D.J. Mol. Psychiatry (2005) [Pubmed]
  7. Gene expression analysis of bipolar disorder reveals downregulation of the ubiquitin cycle and alterations in synaptic genes. Ryan, M.M., Lockstone, H.E., Huffaker, S.J., Wayland, M.T., Webster, M.J., Bahn, S. Mol. Psychiatry (2006) [Pubmed]
  8. Post-high-throughput screening analysis: an empirical compound prioritization scheme. Oprea, T.I., Bologa, C.G., Edwards, B.S., Prossnitz, E.R., Sklar, L.A. Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening. (2005) [Pubmed]
  9. Activation of the melanocortin-4 receptor mobilizes intracellular free calcium in immortalized hypothalamic neurons. Newman, E.A., Chai, B.X., Zhang, W., Li, J.Y., Ammori, J.B., Mulholland, M.W. J. Surg. Res. (2006) [Pubmed]
  10. G protein-coupled receptor kinases. Pitcher, J.A., Freedman, N.J., Lefkowitz, R.J. Annu. Rev. Biochem. (1998) [Pubmed]
  11. Ghrelin: structure and function. Kojima, M., Kangawa, K. Physiol. Rev. (2005) [Pubmed]
  12. Molecular and cellular biology of thyrotropin-releasing hormone receptors. Gershengorn, M.C., Osman, R. Physiol. Rev. (1996) [Pubmed]
  13. Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body. Odorizzi, G., Babst, M., Emr, S.D. Cell (1998) [Pubmed]
  14. A missense mutation of the endothelin-B receptor gene in multigenic Hirschsprung's disease. Puffenberger, E.G., Hosoda, K., Washington, S.S., Nakao, K., deWit, D., Yanagisawa, M., Chakravart, A. Cell (1994) [Pubmed]
  15. Structure and dynamics of metallomacrocycles: recognition of zinc xylyl-bicyclam by an HIV coreceptor. Liang, X., Parkinson, J.A., Weishäupl, M., Gould, R.O., Paisey, S.J., Park, H.S., Hunter, T.M., Blindauer, C.A., Parsons, S., Sadler, P.J. J. Am. Chem. Soc. (2002) [Pubmed]
  16. TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells. Gschwind, A., Hart, S., Fischer, O.M., Ullrich, A. EMBO J. (2003) [Pubmed]
  17. A central role of EGF receptor transactivation in angiotensin II -induced cardiac hypertrophy. Shah, B.H., Catt, K.J. Trends Pharmacol. Sci. (2003) [Pubmed]
  18. E-selectin permits communication between PAF receptors and TRPC channels in human neutrophils. McMeekin, S.R., Dransfield, I., Rossi, A.G., Haslett, C., Walker, T.R. Blood (2006) [Pubmed]
  19. Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer. Goetzl, E.J., Dolezalova, H., Kong, Y., Hu, Y.L., Jaffe, R.B., Kalli, K.R., Conover, C.A. Cancer Res. (1999) [Pubmed]
  20. Cloning of human genes encoding novel G protein-coupled receptors. Marchese, A., Docherty, J.M., Nguyen, T., Heiber, M., Cheng, R., Heng, H.H., Tsui, L.C., Shi, X., George, S.R., O'Dowd, B.F. Genomics (1994) [Pubmed]
  21. Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase. Eggerickx, D., Denef, J.F., Labbe, O., Hayashi, Y., Refetoff, S., Vassart, G., Parmentier, M., Libert, F. Biochem. J. (1995) [Pubmed]
  22. Serotonergic/cholinergic muscle receptor cells in the crab stomatogastric nervous system. I. Identification and characterization of the gastropyloric receptor cells. Katz, P.S., Eigg, M.H., Harris-Warrick, R.M. J. Neurophysiol. (1989) [Pubmed]
  23. Human interferon-gamma-inducible protein 10 (IP-10) inhibits constitutive signaling of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. Geras-Raaka, E., Varma, A., Ho, H., Clark-Lewis, I., Gershengorn, M.C. J. Exp. Med. (1998) [Pubmed]
  24. Infection of mesangial cells with HIV and SIV: identification of GPR1 as a coreceptor. Tokizawa, S., Shimizu, N., Hui-Yu, L., Deyu, F., Haraguchi, Y., Oite, T., Hoshino, H. Kidney Int. (2000) [Pubmed]
  25. Heterologous desensitization of T cell functions by CCR5 and CXCR4 ligands: inhibition of cellular signaling, adhesion and chemotaxis. Hecht, I., Cahalon, L., Hershkoviz, R., Lahat, A., Franitza, S., Lider, O. Int. Immunol. (2003) [Pubmed]
  26. Functional splice variants of the type II G protein-coupled receptor (VPAC2) for vasoactive intestinal peptide in mouse and human lymphocytes. Miller, A.L., Verma, D., Grinninger, C., Huang, M.C., Goetzl, E.J. Ann. N. Y. Acad. Sci. (2006) [Pubmed]
  27. Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection. Farzan, M., Choe, H., Martin, K., Marcon, L., Hofmann, W., Karlsson, G., Sun, Y., Barrett, P., Marchand, N., Sullivan, N., Gerard, N., Gerard, C., Sodroski, J. J. Exp. Med. (1997) [Pubmed]
  28. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Feng, Y., Broder, C.C., Kennedy, P.E., Berger, E.A. Science (1996) [Pubmed]
  29. A synthetic peptide derived from human immunodeficiency virus type 1 gp120 downregulates the expression and function of chemokine receptors CCR5 and CXCR4 in monocytes by activating the 7-transmembrane G-protein-coupled receptor FPRL1/LXA4R. Deng, X., Ueda, H., Su, S.B., Gong, W., Dunlop, N.M., Gao, J.L., Murphy, P.M., Wang, J.M. Blood (1999) [Pubmed]
  30. CXCL-12/stromal cell-derived factor-1alpha transactivates HER2-neu in breast cancer cells by a novel pathway involving Src kinase activation. Cabioglu, N., Summy, J., Miller, C., Parikh, N.U., Sahin, A.A., Tuzlali, S., Pumiglia, K., Gallick, G.E., Price, J.E. Cancer Res. (2005) [Pubmed]
  31. Direct mapping of an agonist-binding domain within the parathyroid hormone/parathyroid hormone-related protein receptor by photoaffinity crosslinking. Zhou, A.T., Bessalle, R., Bisello, A., Nakamoto, C., Rosenblatt, M., Suva, L.J., Chorev, M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  32. Ascaris suum-derived products induce human neutrophil activation via a G protein-coupled receptor that interacts with the interleukin-8 receptor pathway. Falcone, F.H., Rossi, A.G., Sharkey, R., Brown, A.P., Pritchard, D.I., Maizels, R.M. Infect. Immun. (2001) [Pubmed]
  33. R7BP Augments the Function of RGS7{middle dot}Gbeta5 Complexes by a Plasma Membrane-targeting Mechanism. Drenan, R.M., Doupnik, C.A., Jayaraman, M., Buchwalter, A.L., Kaltenbronn, K.M., Huettner, J.E., Linder, M.E., Blumer, K.J. J. Biol. Chem. (2006) [Pubmed]
  34. Intracellular calcium mobilization in response to the activation of human wild-type and chimeric gonadotropin receptors. Lee, P.S., Buchan, A.M., Hsueh, A.J., Yuen, B.H., Leung, P.C. Endocrinology (2002) [Pubmed]
  35. Increased expression of urotensin II and its cognate receptor GPR14 in atherosclerotic lesions of the human aorta. Bousette, N., Patel, L., Douglas, S.A., Ohlstein, E.H., Giaid, A. Atherosclerosis (2004) [Pubmed]
  36. The amino terminus with a conserved glutamic acid of G protein-coupled receptor kinases is indispensable for their ability to phosphorylate photoactivated rhodopsin. Yu, Q.M., Cheng, Z.J., Gan, X.Q., Bao, G.B., Li, L., Pei, G. J. Neurochem. (1999) [Pubmed]
  37. G protein-coupled receptor kinase 2 and beta-arrestins are recruited to FSH receptor in stimulated rat primary Sertoli cells. Marion, S., Kara, E., Crepieux, P., Piketty, V., Martinat, N., Guillou, F., Reiter, E. J. Endocrinol. (2006) [Pubmed]
  38. G-protein-coupled receptor kinase activity is increased in hypertension. Gros, R., Benovic, J.L., Tan, C.M., Feldman, R.D. J. Clin. Invest. (1997) [Pubmed]
  39. Stromal-cell derived factor is expressed by dendritic cells and endothelium in human skin. Pablos, J.L., Amara, A., Bouloc, A., Santiago, B., Caruz, A., Galindo, M., Delaunay, T., Virelizier, J.L., Arenzana-Seisdedos, F. Am. J. Pathol. (1999) [Pubmed]
  40. Characterization of RANTES- and aminooxypentane-RANTES-triggered desensitization signals reveals differences in recruitment of the G protein-coupled receptor complex. Vila-Coro, A.J., Mellado, M., Martín de Ana, A., Martínez-A, C., Rodríguez-Frade, J.M. J. Immunol. (1999) [Pubmed]
  41. Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor. Usdin, T.B., Gruber, C., Bonner, T.I. J. Biol. Chem. (1995) [Pubmed]
  42. Src-mediated RGS16 tyrosine phosphorylation promotes RGS16 stability. Derrien, A., Zheng, B., Osterhout, J.L., Ma, Y.C., Milligan, G., Farquhar, M.G., Druey, K.M. J. Biol. Chem. (2003) [Pubmed]
  43. Mechanisms and modulation of pituitary adenylate cyclase-activating protein-induced calcium mobilization in human neutrophils. Harfi, I., Sariban, E. Ann. N. Y. Acad. Sci. (2006) [Pubmed]
  44. Use of GPR1, GPR15, and STRL33 as coreceptors by diverse human immunodeficiency virus type 1 and simian immunodeficiency virus envelope proteins. Edinger, A.L., Hoffman, T.L., Sharron, M., Lee, B., O'Dowd, B., Doms, R.W. Virology (1998) [Pubmed]
  45. HIV-1 co-receptor expression on trophoblastic cells from early placentas and permissivity to infection by several HIV-1 primary isolates. Mognetti, B., Moussa, M., Croitoru, J., Menu, E., Dormont, D., Roques, P., Chaouat, G. Clin. Exp. Immunol. (2000) [Pubmed]
  46. Chemokine receptors in airway disease: which receptors to target? Owen, C. Pulmonary pharmacology & therapeutics. (2001) [Pubmed]
  47. Generation of a constitutively active mutant of human GPR48/LGR4, a G-protein-coupled receptor. Gao, Y., Kitagawa, K., Shimada, M., Uchida, C., Hattori, T., Oda, T., Kitagawa, M. Hokkaido Igaku Zasshi (2006) [Pubmed]
  48. Development of surface-based assays for transmembrane proteins: selective immobilization of functional CCR5, a G protein-coupled receptor. Silin, V.I., Karlik, E.A., Ridge, K.D., Vanderah, D.J. Anal. Biochem. (2006) [Pubmed]
  49. Neurotensin receptor-1 and -3 complex modulates the cellular signaling of neurotensin in the HT29 cell line. Martin, S., Navarro, V., Vincent, J.P., Mazella, J. Gastroenterology (2002) [Pubmed]
  50. Techniques: GPCR assembly, pharmacology and screening by flow cytometry. Waller, A., Simons, P.C., Biggs, S.M., Edwards, B.S., Prossnitz, E.R., Sklar, L.A. Trends Pharmacol. Sci. (2004) [Pubmed]
  51. A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers. Waldhoer, M., Fong, J., Jones, R.M., Lunzer, M.M., Sharma, S.K., Kostenis, E., Portoghese, P.S., Whistler, J.L. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
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