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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Transcriptional coactivator p300/CBP- associated factor and p300/CBP-associated factor type B are required for normal estrogen response of the mouse uterus.

Mice with targeted gene disruption of one of the estrogen receptor coactivators, p300/CBP-associated factor (PCAF), and its counterpart, PCAF-B, were used to investigate the possible involvement of PCAF and PCAF-B in estrogen receptor-mediated actions in vivo. Among ovariectomized mice that were treated with estrogen, PCAF and PCAF/PCAF-B knockouts showed abnormal growth of the uterus compared with the wild type. The level of c-fos gene expression in the uterus was not induced by estrogen in the knockouts. These observations suggest that PCAF and PCAF-B are required for estrogen-dependent normal growth of the uterus via estrogen receptor-mediated transcriptional regulations.[1]

References

  1. Transcriptional coactivator p300/CBP-associated factor and p300/CBP-associated factor type B are required for normal estrogen response of the mouse uterus. Inoue, E., Hanai, M., Yamada, K., Esashi, T., Yamauchi, J. Biosci. Biotechnol. Biochem. (2004) [Pubmed]
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