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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Kat2b  -  K(lysine) acetyltransferase 2B

Mus musculus

Synonyms: A930006P13Rik, AI461839, AW536563, Histone acetylase PCAF, Histone acetyltransferase KAT2B, ...
 
 
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High impact information on Pcaf

  • Gcn5 (encoded by Gcn5l2) and Pcaf, mouse histone acetyltransferases, share similar sequences and enzymatic activities [1].
  • Finally, these triterpenoids induce expression of the transcriptional coactivator p300-CBP-associated factor and synergize with TGF-beta in this regard [2].
  • These observations suggest that PCAF and PCAF-B are required for estrogen-dependent normal growth of the uterus via estrogen receptor-mediated transcriptional regulations [3].
  • Among ovariectomized mice that were treated with estrogen, PCAF and PCAF/PCAF-B knockouts showed abnormal growth of the uterus compared with the wild type [3].
 

Biological context of Pcaf

  • Embryos null for both Gcn5l2 and Pcaf show even more severe defects, indicating that these histone acetyltransferases have overlapping functions during embryogenesis [1].

References

  1. Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development. Xu, W., Edmondson, D.G., Evrard, Y.A., Wakamiya, M., Behringer, R.R., Roth, S.Y. Nat. Genet. (2000) [Pubmed]
  2. Synthetic triterpenoids enhance transforming growth factor beta/Smad signaling. Suh, N., Roberts, A.B., Birkey Reffey, S., Miyazono, K., Itoh, S., ten Dijke, P., Heiss, E.H., Place, A.E., Risingsong, R., Williams, C.R., Honda, T., Gribble, G.W., Sporn, M.B. Cancer Res. (2003) [Pubmed]
  3. Transcriptional coactivator p300/CBP-associated factor and p300/CBP-associated factor type B are required for normal estrogen response of the mouse uterus. Inoue, E., Hanai, M., Yamada, K., Esashi, T., Yamauchi, J. Biosci. Biotechnol. Biochem. (2004) [Pubmed]
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