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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Assessing activation of the human neuropeptide FF2 receptor with a non-radioactive GTP binding assay.

We have evaluated a novel, time-resolved fluorometric GTP binding assay for its suitability for functional screening of neuropeptide FF (NPFF) receptor ligands. Our results suggest that this assay, which relies on the use of a europium-labeled GTP analogue, Eu-GTP, provides a powerful alternative to the [35S]guanosine-5'-O-(3-thio)triphosphate binding assay for assessing the functional properties of NPFF analogs. Further, we demonstrate that the tetrapeptide PMRF-NH2 exhibited high agonist potency at the NPFF2 receptor, and that the efficacies of this peptide and another shortened NPFF analog were greater than that of NPFF.[1]

References

  1. Assessing activation of the human neuropeptide FF2 receptor with a non-radioactive GTP binding assay. Engström, M., Närvänen, A., Savola, J.M., Wurster, S. Peptides (2004) [Pubmed]
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