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Chemical Compound Review

NPFF     (2S)-2-[[(2S)-1-[(2S)-4- aminocarbonyl-2...

Synonyms: Flfqpqrf-NH2, F8Famide, F-8-F-Amide, F-8-F-NH2, LS-178422, ...
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Disease relevance of Fmrfamide-like octapeptide


Psychiatry related information on Fmrfamide-like octapeptide


High impact information on Fmrfamide-like octapeptide

  • Anti-opioid effects of neuropeptide FF were found to require a functional PrRP-GPR10 system [7].
  • We found that neuropeptide FF (Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe amide) and FMRFamide (Phe-Met-Arg-Phe amide) generated no current on their own but potentiated H+-gated currents from cultured sensory neurons and heterologously expressed ASIC and DRASIC channels [8].
  • Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels [8].
  • Neuropeptide FF (NPFF) has been proposed to play a role in pain modulation, opioid tolerance, and several other physiological processes [9].
  • Identification and characterization of two G protein-coupled receptors for neuropeptide FF [10].

Biological context of Fmrfamide-like octapeptide


Anatomical context of Fmrfamide-like octapeptide


Associations of Fmrfamide-like octapeptide with other chemical compounds


Gene context of Fmrfamide-like octapeptide


Analytical, diagnostic and therapeutic context of Fmrfamide-like octapeptide


  1. Neuropeptide FF (NPFF) analogs functionally antagonize opioid activities in NPFF2 receptor-transfected SH-SY5Y neuroblastoma cells. Mollereau, C., Mazarguil, H., Zajac, J.M., Roumy, M. Mol. Pharmacol. (2005) [Pubmed]
  2. Release of neuropeptide FF, an anti-opioid peptide, in rat spinal cord slices is voltage- and Ca(2+)-sensitive: possible involvement of P-type Ca2+ channels. Devillers, J.P., Labrouche, S.A., Castes, E., Simonnet, G. J. Neurochem. (1995) [Pubmed]
  3. Neuropeptide FF, but not prolactin-releasing peptide, mRNA is differentially regulated in the hypothalamic and medullary neurons after salt loading. Kalliomäki, M.L., Panula, P. Neuroscience (2004) [Pubmed]
  4. Opposing interplay between Neuropeptide FF and nitric oxide in antinociception and hypothermia. Zajac, J.M., Latapie, J.P., Francés, B. Peptides (2000) [Pubmed]
  5. Cholera and pertussis toxins inhibit differently hypothermic and anti-opioid effects of neuropeptide FF. Francés, B., Lahlou, H., Zajac, J.M. Regul. Pept. (2001) [Pubmed]
  6. Changes in CNS neuropeptide FF-like material, pain sensitivity, and opiate dependence following chronic morphine treatment. Stinus, L., Allard, M., Gold, L., Simonnet, G. Peptides (1995) [Pubmed]
  7. The prolactin-releasing peptide antagonizes the opioid system through its receptor GPR10. Laurent, P., Becker, J.A., Valverde, O., Ledent, C., de Kerchove d'Exaerde, A., Schiffmann, S.N., Maldonado, R., Vassart, G., Parmentier, M. Nat. Neurosci. (2005) [Pubmed]
  8. Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels. Askwith, C.C., Cheng, C., Ikuma, M., Benson, C., Price, M.P., Welsh, M.J. Neuron (2000) [Pubmed]
  9. RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. Simonin, F., Schmitt, M., Laulin, J.P., Laboureyras, E., Jhamandas, J.H., MacTavish, D., Matifas, A., Mollereau, C., Laurent, P., Parmentier, M., Kieffer, B.L., Bourguignon, J.J., Simonnet, G. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  10. Identification and characterization of two G protein-coupled receptors for neuropeptide FF. Bonini, J.A., Jones, K.A., Adham, N., Forray, C., Artymyshyn, R., Durkin, M.M., Smith, K.E., Tamm, J.A., Boteju, L.W., Lakhlani, P.P., Raddatz, R., Yao, W.J., Ogozalek, K.L., Boyle, N., Kouranova, E.V., Quan, Y., Vaysse, P.J., Wetzel, J.M., Branchek, T.A., Gerald, C., Borowsky, B. J. Biol. Chem. (2000) [Pubmed]
  11. Analysis of human neuropeptide FF gene expression. Nystedt, J.M., Brandt, A.M., Mandelin, J., Vilim, F.S., Ziff, E.B., Panula, P. J. Neurochem. (2002) [Pubmed]
  12. Regulation of endogenous human NPFF2 receptor by neuropeptide FF in SK-N-MC neuroblastoma cell line. Ankö, M.L., Panula, P. J. Neurochem. (2006) [Pubmed]
  13. Interaction between neuropeptide FF and opioids in the ventral tegmental area in the behavioral response to novelty. Cador, M., Marco, N., Stinus, L., Simonnet, G. Neuroscience (2002) [Pubmed]
  14. Ontogeny of the F8Famide-like (morphine-modulating) peptides in the central nervous system of rats. Kivipelto, L., Rubenstein, J., Yang, H.Y., Panula, P. J. Comp. Neurol. (1991) [Pubmed]
  15. Neuropeptide FF, a mammalian neuropeptide with multiple functions. Panula, P., Aarnisalo, A.A., Wasowicz, K. Prog. Neurobiol. (1996) [Pubmed]
  16. Modulation of neuropeptide FF receptors by guanine nucleotides and cations in membranes of rat brain and spinal cord. Payza, K., Yang, H.Y. J. Neurochem. (1993) [Pubmed]
  17. Activation of neuropeptide FF neurons in the brainstem nucleus tractus solitarius following cardiovascular challenge and opiate withdrawal. Jhamandas, J.H., Harris, K.H., Petrov, T., Yang, H.Y., Jhamandas, K.H. J. Comp. Neurol. (1998) [Pubmed]
  18. Immunocytochemical localization of neuropeptide FF (FMRF amide-like peptide) in the hypothalamo-neurohypophyseal system of Wistar and Brattleboro rats by light and electron microscopy. Boersma, C.J., Sonnemans, M.A., Van Leeuwen, F.W. J. Comp. Neurol. (1993) [Pubmed]
  19. The neuropeptide FF analogue, 1DME, enhances in vivo met-enkephalin release from the rat spinal cord. Ballet, S., Mauborgne, A., Gouardères, C., Bourgoin, A.S., Zajac, J.M., Hamon, M., Cesselin, F. Neuropharmacology (1999) [Pubmed]
  20. Distribution of neuropeptide FF in porcine spinal cord in comparison with other neuropeptides and serotonin. Wasowicz, K., Panula, P. J. Comp. Neurol. (1994) [Pubmed]
  21. Modulation of neuropeptide FF release from rat spinal cord slices by glutamate. Involvement of NMDA receptors. Devillers, J.P., Simonnet, G. Eur. J. Pharmacol. (1994) [Pubmed]
  22. Cardiovascular effects induced by the stimulation of neuropeptide FF receptors in the dorsal vagal complex: an autoradiographic and pharmacological study in the rat. Laguzzi, R., Nosjean, A., Mazarguil, H., Allard, M. Brain Res. (1996) [Pubmed]
  23. Agonist and antagonist activities on human NPFF(2) receptors of the NPY ligands GR231118 and BIBP3226. Mollereau, C., Gouardères, C., Dumont, Y., Kotani, M., Detheux, M., Doods, H., Parmentier, M., Quirion, R., Zajac, J.M. Br. J. Pharmacol. (2001) [Pubmed]
  24. Effects of neuropeptide SF and related peptides on acid sensing ion channel 3 and sensory neuron excitability. Deval, E., Baron, A., Lingueglia, E., Mazarguil, H., Zajac, J.M., Lazdunski, M. Neuropharmacology (2003) [Pubmed]
  25. Discovery and mapping of ten novel G protein-coupled receptor genes. Lee, D.K., Nguyen, T., Lynch, K.R., Cheng, R., Vanti, W.B., Arkhitko, O., Lewis, T., Evans, J.F., George, S.R., O'Dowd, B.F. Gene (2001) [Pubmed]
  26. The neuropeptide FF analogue, 1DMe, reduces in vivo dynorphin release from the rat spinal cord. Ballet, S., Braz, J., Mauborgne, A., Bourgoin, S., Zajac, J.M., Hamon, M., Cesselin, F. J. Neurochem. (2002) [Pubmed]
  27. Neuropeptide FF-containing efferent projections from the medial hypothalamus of rat: a Phaseolus vulgaris leucoagglutinin study. Aarnisalo, A.A., Panula, P. Neuroscience (1995) [Pubmed]
  28. Isolation, characterization, and distribution of a novel neuropeptide, Rana RFamide (R-RFa), in the brain of the European green frog Rana esculenta. Chartrel, N., Dujardin, C., Leprince, J., Desrues, L., Tonon, M.C., Cellier, E., Cosette, P., Jouenne, T., Simonnet, G., Vaudry, H. J. Comp. Neurol. (2002) [Pubmed]
  29. A differential modulation of allodynia, hyperalgesia and nociception by neuropeptide FF in the periaqueductal gray of neuropathic rats: interactions with morphine and naloxone. Wei, H., Panula, P., Pertovaara, A. Neuroscience (1998) [Pubmed]
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