- Tacrolimus reduces urinary excretion of leukotriene E(4) and inhibits aspirin-induced asthma to threshold dose of aspirin. Kawano, T., Matsuse, H., Kondo, Y., Machida, I., Saeki, S., Tomari, S., Mitsuta, K., Fukushima, C., Obase, Y., Shimoda, T., Kohno, S. J. Allergy Clin. Immunol. (2004)