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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Organ Transplantation

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Disease relevance of Organ Transplantation


Psychiatry related information on Organ Transplantation


High impact information on Organ Transplantation


Chemical compound and disease context of Organ Transplantation


Biological context of Organ Transplantation


Anatomical context of Organ Transplantation


Associations of Organ Transplantation with chemical compounds


Gene context of Organ Transplantation

  • Isolation of the ninaA gene by chromosomal walking revealed that it is expressed only in the eye and encodes a 237-amino acid polypeptide that shows strong sequence similarity to cyclophilin, a putative molecular target for cyclosporine A, a potent immunosuppressant used in human organ transplantations [32].
  • However, immunosuppressants and several other drugs used after organ transplantation are cytochrome P4503A (CYP3A, EC substrates [33].
  • These observations suggest potential therapeutic applications of IL-10 in organ transplantation, especially in association with anti-CD3 mAb [34].
  • BACKGROUND: The effects of the ischemia-reperfusion process of organ transplantation on nitric oxide (NO) synthase (NOS) in humans are unknown [35].
  • It is generally accepted that donor myeloid dendritic cells (MDC) are the main instigators of acute rejection after organ transplantation [36].

Analytical, diagnostic and therapeutic context of Organ Transplantation


  1. CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes. Tiede, I., Fritz, G., Strand, S., Poppe, D., Dvorsky, R., Strand, D., Lehr, H.A., Wirtz, S., Becker, C., Atreya, R., Mudter, J., Hildner, K., Bartsch, B., Holtmann, M., Blumberg, R., Walczak, H., Iven, H., Galle, P.R., Ahmadian, M.R., Neurath, M.F. J. Clin. Invest. (2003) [Pubmed]
  2. Hepatic glutamine synthetase deficiency in fatal hyperammonemia after lung transplantation. Tuchman, M., Lichtenstein, G.R., Rajagopal, B.S., McCann, M.T., Furth, E.E., Bavaria, J., Kaplan, P.B., Gibson, J.B., Berry, G.T. Ann. Intern. Med. (1997) [Pubmed]
  3. Post-transplant lymphoproliferative disorders. Gottschalk, S., Rooney, C.M., Heslop, H.E. Annu. Rev. Med. (2005) [Pubmed]
  4. Calcitriol directly sensitizes renal tubular cells to ATP-depletion- and iron-mediated attack. Zager, R.A. Am. J. Pathol. (1999) [Pubmed]
  5. Epstein-Barr virus transmission via the donor organs in solid organ transplantation: polymerase chain reaction and restriction fragment length polymorphism analysis of IR2, IR3, and IR4. Cen, H., Breinig, M.C., Atchison, R.W., Ho, M., McKnight, J.L. J. Virol. (1991) [Pubmed]
  6. Patient compliance with cyclosporine regimen post solid organ transplantation. Mozaffari, E., Satake, J., Woo, A., Suko, J., Correia, R. Transplant. Proc. (1999) [Pubmed]
  7. The case for matching MHC genes in human organ transplantation. Martin, S., Dyer, P.A. Nat. Genet. (1993) [Pubmed]
  8. Cyclosporine induces cancer progression by a cell-autonomous mechanism. Hojo, M., Morimoto, T., Maluccio, M., Asano, T., Morimoto, K., Lagman, M., Shimbo, T., Suthanthiran, M. Nature (1999) [Pubmed]
  9. Detection of factor VIII/coagulant antigen in human liver tissue. Stel, H.V., van der Kwast, T.H., Veerman, E.C. Nature (1983) [Pubmed]
  10. HLA-G molecules: from maternal-fetal tolerance to tissue acceptance. Carosella, E.D., Moreau, P., Le Maoult, J., Le Discorde, M., Dausset, J., Rouas-Freiss, N. Adv. Immunol. (2003) [Pubmed]
  11. Waiting for organ transplantation. Institute of Medicine Committee on Organ Transplantation. Gibbons, R.D., Meltzer, D., Duan, N. Science (2000) [Pubmed]
  12. Salmon calcitonin prevents cyclosporin-A-induced high turnover bone loss. Stein, B., Takizawa, M., Katz, I., Joffe, I., Berlin, J., Fallon, M., Epstein, S. Endocrinology (1991) [Pubmed]
  13. Toxic neuropathies. Mizisin, A.P., Powell, H.C. Curr. Opin. Neurol. (1995) [Pubmed]
  14. Mycophenolic acid antagonizes the activation of cultured human mesangial cells. Dubus, I., Vendrely, B., Christophe, I., Labouyrie, J.P., Delmas, Y., Bonnet, J., Combe, C. Kidney Int. (2002) [Pubmed]
  15. Hydrocortisone activation of human herpesvirus 8 viral DNA replication and gene expression in vitro. Hudnall, S.D., Rady, P.L., Tyring, S.K., Fish, J.C. Transplantation (1999) [Pubmed]
  16. Ganciclovir nucleotides accumulate in mitochondria of rat liver cells expressing the herpes simplex virus thymidine kinase gene. van der Eb, M.M., Geutskens, S.B., van Kuilenburg, A.B., van Lenthe, H., van Dierendonck, J.H., Kuppen, P.J., van Ormondt, H., van de Velde, C.J., Wanders, R.J., van Gennip, A.H., Hoeben, R.C. The journal of gene medicine. (2003) [Pubmed]
  17. Successful treatment of recurrent rejection in renal transplant patients with photopheresis. Dall'Amico, R., Murer, L., Montini, G., Andreetta, B., Zanon, G.F., Zacchello, G., Zacchello, F. J. Am. Soc. Nephrol. (1998) [Pubmed]
  18. Relationship of mycophenolic acid exposure to clinical outcome after hematopoietic cell transplantation. Jacobson, P., Rogosheske, J., Barker, J.N., Green, K., Ng, J., Weisdorf, D., Tan, Y., Long, J., Remmel, R., Sawchuk, R., McGlave, P. Clin. Pharmacol. Ther. (2005) [Pubmed]
  19. Drug interaction between mycophenolate mofetil and rifampin: possible induction of uridine diphosphate-glucuronosyltransferase. Kuypers, D.R., Verleden, G., Naesens, M., Vanrenterghem, Y. Clin. Pharmacol. Ther. (2005) [Pubmed]
  20. 27. Transplantation immunology: organ and bone marrow. Buckley, R.H. J. Allergy Clin. Immunol. (2003) [Pubmed]
  21. Effective use of donor MHC class I gene therapy in organ transplantation: prevention of antibody-mediated hyperacute heart allograft rejection in highly sensitized rat recipients. Geissler, E.K., Graeb, C., Tange, S., Guba, M., Jauch, K.W., Scherer, M.N. Hum. Gene Ther. (2000) [Pubmed]
  22. Distinct histologic patterns of acute, prolonged, and chronic rejection in vascularized rat pancreas allografts. Steiniger, B., Klempnauer, J. Am. J. Pathol. (1986) [Pubmed]
  23. Side effects of systemic cyclosporine in patients not undergoing transplantation. Palestine, A.G., Nussenblatt, R.B., Chan, C.C. Am. J. Med. (1984) [Pubmed]
  24. alpha1,3-Galactosyltransferase gene-knockout miniature swine produce natural cytotoxic anti-Gal antibodies. Dor, F.J., Tseng, Y.L., Cheng, J., Moran, K., Sanderson, T.M., Lancos, C.J., Shimizu, A., Yamada, K., Awwad, M., Sachs, D.H., Hawley, R.J., Schuurman, H.J., Cooper, D.K. Transplantation (2004) [Pubmed]
  25. Selective effect of noncytotoxic blocking alloantibodies produced after platelet transfusions on MLC, and mitogen and soluble antigen-induced responses of human lymphocytes. Horuzsko, A., Gyódi, E., Réti, M., Mayer, K., Kassay, M., Petrányi, G. Transplantation (1990) [Pubmed]
  26. UW is superior to Celsior and HTK in the protection of human liver endothelial cells against preservation injury. Janssen, H., Janssen, P.H., Broelsch, C.E. Liver Transpl. (2004) [Pubmed]
  27. Role of postreplicative DNA mismatch repair in the cytotoxic action of thioguanine. Swann, P.F., Waters, T.R., Moulton, D.C., Xu, Y.Z., Zheng, Q., Edwards, M., Mace, R. Science (1996) [Pubmed]
  28. Cardiac preservation is enhanced in a heterotopic rat transplant model by supplementing the nitric oxide pathway. Pinsky, D.J., Oz, M.C., Koga, S., Taha, Z., Broekman, M.J., Marcus, A.J., Liao, H., Naka, Y., Brett, J., Cannon, P.J. J. Clin. Invest. (1994) [Pubmed]
  29. Biopterin and organ transplantation. Dhondt, J.L., Walter, M.P., Bauters, F., Jouet, J.P. Lancet (1988) [Pubmed]
  30. The status of cardiac transplantation, 1975. Rider, A.K., Copeland, J.G., Hunt, S.A., Mason, J., Specter, M.J., Winkle, R.A., Bieber, C.P., Billingham, M.E., Dong, E., Griepp, R.B., Schroeder, J.S., Stinson, E.B., Harrison, D.C., Shumway, N.E. Circulation (1975) [Pubmed]
  31. The nitric oxide/cyclic GMP pathway in organ transplantation: critical role in successful lung preservation. Pinsky, D.J., Naka, Y., Chowdhury, N.C., Liao, H., Oz, M.C., Michler, R.E., Kubaszewski, E., Malinski, T., Stern, D.M. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  32. Drosophila ninaA gene encodes an eye-specific cyclophilin (cyclosporine A binding protein). Schneuwly, S., Shortridge, R.D., Larrivee, D.C., Ono, T., Ozaki, M., Pak, W.L. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  33. Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in transplant patients: are the statins mechanistically similar? Christians, U., Jacobsen, W., Floren, L.C. Pharmacol. Ther. (1998) [Pubmed]
  34. Modulation of the release of cytokines and reduction of the shock syndrome induced by anti-CD3 monoclonal antibody in mice by interleukin-10. Donckier, V., Flament, V., Gérard, C., Abramowicz, D., Vandenabeele, P., Wissing, M., Delvaux, A., Fiers, W., Leo, O., Velu, T. Transplantation (1994) [Pubmed]
  35. Increased expression of nitric oxide synthase in human lung transplants after nitric oxide inhalation. Cardella, J.A., Keshavjee, S.H., Bai, X.H., Yeoh, J.S., Granton, J.T., Meade, M.O., Matte-Martyn, A., Waddell, T.K., Liu, M. Transplantation (2004) [Pubmed]
  36. Characterization of human liver dendritic cells in liver grafts and perfusates. Bosma, B.M., Metselaar, H.J., Mancham, S., Boor, P.P., Kusters, J.G., Kazemier, G., Tilanus, H.W., Kuipers, E.J., Kwekkeboom, J. Liver Transpl. (2006) [Pubmed]
  37. Therapy with monoclonal antibody to interleukin 2 receptor spares suppressor T cells and prevents or reverses acute allograft rejection in rats. Kupiec-Weglinski, J.W., Diamantstein, T., Tilney, N.L., Strom, T.B. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  38. The use of Cyclosporin A immunosuppression in organ grafting. White, D.J., Calne, R.Y. Immunol. Rev. (1982) [Pubmed]
  39. Transcription of human ABO histo-blood group genes is dependent upon binding of transcription factor CBF/NF-Y to minisatellite sequence. Kominato, Y., Tsuchiya, T., Hata, N., Takizawa, H., Yamamoto, F. J. Biol. Chem. (1997) [Pubmed]
  40. Expression of fibronectin splicing variants in organ transplantation: a differential pattern between rat cardiac allografts and isografts. Coito, A.J., Brown, L.F., Peters, J.H., Kupiec-Weglinski, J.W., van de Water, L. Am. J. Pathol. (1997) [Pubmed]
  41. Strategies to minimize immunological and nonimmunological risk factors in the renal transplant population. First, M.R. Transplantation (2001) [Pubmed]
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