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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Eosinophilic leukemic transformation in polycythemia rubra vera ( PRV).

We report a rare case of eosinophilic leukemia transformation in a patient with polycythemia rubra vera on hydroxycarbamide (hydroxyurea) therapy only. Cytogenetic study showed complex abnormalities including -5, -7, +8, suggestive of a secondary leukemia. The leukemogenic risk of hydroxycarbamide, a ribonucleoside reductase, and the risk of natural leukemic transformation of polycythemia rubra vera is discussed in the context of previous PVSG studies.[1]

References

  1. Eosinophilic leukemic transformation in polycythemia rubra vera (PRV). Chim, C.S., Ma, S.K. Leuk. Lymphoma (2005) [Pubmed]
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