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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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2-(4-alkylpiperazin-1-yl)quinolines as a new class of imidazole-free histamine H3 receptor antagonists.

With the aim of identifying structurally novel, centrally acting histamine H(3) antagonists, a series of 2-(4-alkylpiperazin-1-yl)quinolines was prepared. Systematic variation of the substituents led to highly potent histamine H(3) antagonists with low polar surface area and appropriate log P for blood-brain barrier penetration.[1]

References

  1. 2-(4-alkylpiperazin-1-yl)quinolines as a new class of imidazole-free histamine H3 receptor antagonists. Zaragoza, F., Stephensen, H., Peschke, B., Rimvall, K. J. Med. Chem. (2005) [Pubmed]
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