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Gene Review

HRH3  -  histamine receptor H3

Homo sapiens

Synonyms: G-protein coupled receptor 97, GPCR97, H3R, HH3R, Histamine H3 receptor
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Disease relevance of HRH3


Psychiatry related information on HRH3


High impact information on HRH3


Chemical compound and disease context of HRH3


Biological context of HRH3


Anatomical context of HRH3


Associations of HRH3 with chemical compounds


Regulatory relationships of HRH3


Other interactions of HRH3


Analytical, diagnostic and therapeutic context of HRH3


  1. Structure of the human histamine H3 receptor gene (HRH3) and identification of naturally occurring variations. Wiedemann, P., Bönisch, H., Oerters, F., Brüss, M. Journal of neural transmission (Vienna, Austria : 1996) (2002) [Pubmed]
  2. Opposite functions of histamine H1 and H2 receptors and H3 receptor in substantia nigra pars reticulata. Zhou, F.W., Xu, J.J., Zhao, Y., LeDoux, M.S., Zhou, F.M. J. Neurophysiol. (2006) [Pubmed]
  3. Histamine receptors influence blood-spinal cord barrier permeability, edema formation, and spinal cord blood flow following trauma to the rat spinal cord. Sharma, H.S., Vannemreddy, P., Patnaik, R., Patnaik, S., Mohanty, S. Acta Neurochir. Suppl. (2006) [Pubmed]
  4. Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus. Yoshimoto, R., Miyamoto, Y., Shimamura, K., Ishihara, A., Takahashi, K., Kotani, H., Chen, A.S., Chen, H.Y., Macneil, D.J., Kanatani, A., Tokita, S. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  5. Purification of a histamine H3 receptor negatively coupled to phosphoinositide turnover in the human gastric cell line HGT1. Cherifi, Y., Pigeon, C., Le Romancer, M., Bado, A., Reyl-Desmars, F., Lewin, M.J. J. Biol. Chem. (1992) [Pubmed]
  6. The histamine H3 receptor as a novel therapeutic target for cognitive and sleep disorders. Passani, M.B., Lin, J.S., Hancock, A., Crochet, S., Blandina, P. Trends Pharmacol. Sci. (2004) [Pubmed]
  7. Decreased intracellular calcium mediates the histamine H3-receptor-induced attenuation of norepinephrine exocytosis from cardiac sympathetic nerve endings. Silver, R.B., Poonwasi, K.S., Seyedi, N., Wilson, S.J., Lovenberg, T.W., Levi, R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  8. Selective histamine H3 receptor antagonists for treatment of cognitive deficiencies and other disorders of the central nervous system. Witkin, J.M., Nelson, D.L. Pharmacol. Ther. (2004) [Pubmed]
  9. Histamine H3 receptor agonists reduce L-dopa-induced chorea, but not dystonia, in the MPTP-lesioned nonhuman primate model of Parkinson's disease. Gomez-Ramirez, J., Johnston, T.H., Visanji, N.P., Fox, S.H., Brotchie, J.M. Mov. Disord. (2006) [Pubmed]
  10. Molecular cloning and characterization of a new human histamine receptor, HH4R. Nakamura, T., Itadani, H., Hidaka, Y., Ohta, M., Tanaka, K. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  11. Cloning and functional expression of the human histamine H3 receptor. Lovenberg, T.W., Roland, B.L., Wilson, S.J., Jiang, X., Pyati, J., Huvar, A., Jackson, M.R., Erlander, M.G. Mol. Pharmacol. (1999) [Pubmed]
  12. Genomic organization and characterization of splice variants of the human histamine H3 receptor. Cogé, F., Guénin, S.P., Audinot, V., Renouard-Try, A., Beauverger, P., Macia, C., Ouvry, C., Nagel, N., Rique, H., Boutin, J.A., Galizzi, J.P. Biochem. J. (2001) [Pubmed]
  13. Increased concentrations of histamine and its metabolite, tele-methylhistamine and down-regulation of histamine H3 receptor sites in autopsied brain tissue from cirrhotic patients who died in hepatic coma. Lozeva, V., Tuomisto, L., Tarhanen, J., Butterworth, R.F. J. Hepatol. (2003) [Pubmed]
  14. Azomethine prodrugs of (R)-alpha-methylhistamine, a highly potent and selective histamine H3-receptor agonist. Krause, M., Stark, H., Schunack, W. Current medicinal chemistry. (2001) [Pubmed]
  15. Photoperiodic regulation of histamine H3 receptor and VGF messenger ribonucleic acid in the arcuate nucleus of the Siberian hamster. Barrett, P., Ross, A.W., Balik, A., Littlewood, P.A., Mercer, J.G., Moar, K.M., Sallmen, T., Kaslin, J., Panula, P., Schuhler, S., Ebling, F.J., Ubeaud, C., Morgan, P.J. Endocrinology (2005) [Pubmed]
  16. Activation of histamine H3 receptors in human nasal mucosa inhibits sympathetic vasoconstriction. Varty, L.M., Gustafson, E., Laverty, M., Hey, J.A. Eur. J. Pharmacol. (2004) [Pubmed]
  17. Inhibition of noradrenaline release from the sympathetic nerves of the human saphenous vein by presynaptic histamine H3 receptors. Molderings, G.J., Weissenborn, G., Schlicker, E., Likungu, J., Göthert, M. Naunyn Schmiedebergs Arch. Pharmacol. (1992) [Pubmed]
  18. Regulation of ion transport by histamine in human colon. Keely, S.J., Stack, W.A., O'Donoghue, D.P., Baird, A.W. Eur. J. Pharmacol. (1995) [Pubmed]
  19. 2-(4-alkylpiperazin-1-yl)quinolines as a new class of imidazole-free histamine H3 receptor antagonists. Zaragoza, F., Stephensen, H., Peschke, B., Rimvall, K. J. Med. Chem. (2005) [Pubmed]
  20. Histamine H3 receptor antagonists: preclinical promise for treating obesity and cognitive disorders. Esbenshade, T.A., Fox, G.B., Cowart, M.D. Mol. Interv. (2006) [Pubmed]
  21. Separation of chiral 4-substituted imidazole derivatives by cyclodextrin-modified capillary electrophoresis. Sasse, A., Schunack, W., Stark, H. Biomed. Chromatogr. (2001) [Pubmed]
  22. Increased brain histamine H3 receptor expression during hibernation in golden-mantled ground squirrels. Sallmen, T., Lozada, A.F., Anichtchik, O.V., Beckman, A.L., Panula, P. BMC neuroscience [electronic resource]. (2003) [Pubmed]
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