The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Glioksal     1H-imidazole

Synonyms: Imidazol, Glyoxalin, Iminazole, Miazole, imidazole, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Imidazole Ring Bound At Distal Site


Psychiatry related information on Imidazole Ring Bound At Distal Site


High impact information on Imidazole Ring Bound At Distal Site

  • By incorporation of this third amino acid, hydroxypyrrole-imidazole-pyrrole polyamides form four ring-pairings (Im/Py, Py/Im, Hp/Py and Py/Hp) which distinguish all four Watson-Crick base pairs in the minor groove of DNA [8].
  • In alkaline conditions, the imidazole ring of mG opens up, yielding the ring-opened form 2,6-diamino-4-oxo-5-methylformamidopyrimidine (rom7G); this lesion is a block to DNA replication [9].
  • We find that TTX and imidazole affect the maximal rate of rise of the action potential in a temperature-dependent manner [10].
  • A cytochrome c oxidase model that consists of a cobalt(II) porphyrin with a copper(I) triazacyclononane macrocycle fastened on the distal face and an imidazole covalently attached to the proximal face has been synthesized and characterized [11].
  • The Tyr34 residue of VL was substituted by His in order to introduce a catalytic imidazole into the combining site for the ester hydrolysis [12].

Chemical compound and disease context of Imidazole Ring Bound At Distal Site


Biological context of Imidazole Ring Bound At Distal Site


Anatomical context of Imidazole Ring Bound At Distal Site


Associations of Imidazole Ring Bound At Distal Site with other chemical compounds


Gene context of Imidazole Ring Bound At Distal Site

  • We have studied the effects of two new synthetic triterpenoids, 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) and its derivative, 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole (CDDO-Im), on transforming growth factor (TGF)-beta/Smad signaling [31].
  • Hence, the combination of PDT with pyridinyl imidazole inhibitors of p38 MAPK may improve the therapeutic efficacy of PDT by blocking COX-2 up-regulation, which contributes to tumor growth by the release of growth- and pro-angiogenic factors, as well as by sensitizing cancer cells to apoptosis [32].
  • The binding of chlorzoxazone to iNOS and human and rat liver microsomal cytochrome P-450 induced a high spin, type I spectra, which was reversed by imidazole [33].
  • Therefore, the suppression of Cyp1a1 transcription by pyridinyl imidazole compounds is not because of their inhibition of p38 MAP kinase activity [34].
  • To determine the functional significance of the observed activation of p38 MAPK in response to insulin and osmotic shock, we used three pyridinyl imidazole p38 MAPK inhibitors, SB203580, SB202190, and PD169316 [35].

Analytical, diagnostic and therapeutic context of Imidazole Ring Bound At Distal Site


  1. The effect of hepatic enzyme-inducing drugs on thyroid hormones and the thyroid gland. Curran, P.G., DeGroot, L.J. Endocr. Rev. (1991) [Pubmed]
  2. Imidazole rescue of a cytosine mutation in a self-cleaving ribozyme. Perrotta, A.T., Shih, I., Been, M.D. Science (1999) [Pubmed]
  3. Inhibition of Ca(2+)-dependent K+ transport and cell dehydration in sickle erythrocytes by clotrimazole and other imidazole derivatives. Brugnara, C., de Franceschi, L., Alper, S.L. J. Clin. Invest. (1993) [Pubmed]
  4. Acetyl glyceryl ether phosphorylcholine-stimulated human platelets cause pulmonary hypertension and edema in isolated rabbit lungs. Role of thromboxane A2. Heffner, J.E., Shoemaker, S.A., Canham, E.M., Patel, M., McMurtry, I.F., Morris, H.G., Repine, J.E. J. Clin. Invest. (1983) [Pubmed]
  5. Crystal structures of the active site in specifically metal-depleted and cobalt-substituted horse liver alcohol dehydrogenase derivatives. Schneider, G., Eklund, H., Cedergren-Zeppezauer, E., Zeppezauer, M. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  6. Evidence for tolerance following repeated dosing in rats with ciproxifan, but not with A-304121. Pan, J.B., Yao, B.B., Miller, T.R., Kroeger, P.E., Bennani, Y.L., Komater, V.A., Esbenshade, T.A., Hancock, A.A., Decker, M.W., Fox, G.B. Life Sci. (2006) [Pubmed]
  7. Ketoconazole binds to the human androgen receptor. Eil, C. Horm. Metab. Res. (1992) [Pubmed]
  8. Recognition of the four Watson-Crick base pairs in the DNA minor groove by synthetic ligands. White, S., Szewczyk, J.W., Turner, J.M., Baird, E.E., Dervan, P.B. Nature (1998) [Pubmed]
  9. Ring-opened alkylated guanine is not repaired in Z-DNA. Lagravère, C., Malfoy, B., Leng, M., Laval, J. Nature (1984) [Pubmed]
  10. Imidazole inhibits a temperature-dependent component of mammalial skeletal muscle action potential. Cheung, D.W., Daniel, E.E. Nature (1980) [Pubmed]
  11. A functional model related to cytochrome c oxidase and its electrocatalytic four-electron reduction of O2. Collman, J.P., Fu, L., Herrmann, P.C., Zhang, X. Science (1997) [Pubmed]
  12. Generation of a catalytic antibody by site-directed mutagenesis. Baldwin, E., Schultz, P.G. Science (1989) [Pubmed]
  13. Identification of histidine at the catalytic site of the photosynthetic oxygen-evolving complex. Tang, X.S., Diner, B.A., Larsen, B.S., Gilchrist, M.L., Lorigan, G.A., Britt, R.D. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  14. Relationship of mitochondrial membrane potential to hemoglobin synthesis during Friend cell maturation. Wong, W., Robinson, S.H., Tsiftsoglou, A.S. Blood (1985) [Pubmed]
  15. Differential effect of imidazole antibiotics on untransformed and virus-transformed rat cell lines. Kuwano, M., Akiyama, S., Kaneko, M., Ikezaki, K., Takaki, R., Kimura, G. Cancer Res. (1982) [Pubmed]
  16. Imidazole antifungals Miconazole and Econazole induce apoptosis in mouse lymphoma and human T cell leukemia cells: regulation by Bcl-2 and potential role of calcium. Sobecks, R., McCormick, T.S., Distelhorst, C.W. Cell Death Differ. (1996) [Pubmed]
  17. Randomized comparison of three adriamycin regimens for metastatic soft tissue sarcomas. Borden, E.C., Amato, D.A., Rosenbaum, C., Enterline, H.T., Shiraki, M.J., Creech, R.H., Lerner, H.J., Carbone, P.P. J. Clin. Oncol. (1987) [Pubmed]
  18. Oxygen metabolites stimulate thromboxane production and vasoconstriction in isolated saline-perfused rabbit lungs. Tate, R.M., Morris, H.G., Schroeder, W.R., Repine, J.E. J. Clin. Invest. (1984) [Pubmed]
  19. Prostaglandins mediate the vasodilatory effect of mannitol in the hypoperfused rat kidney. Johnston, P.A., Bernard, D.B., Perrin, N.S., Levinsky, N.G. J. Clin. Invest. (1981) [Pubmed]
  20. Obstructive nephropathy in the rat: possible roles for the renin-angiotensin system, prostaglandins, and thromboxanes in postobstructive renal function. Yarger, W.E., Schocken, D.D., Harris, R.H. J. Clin. Invest. (1980) [Pubmed]
  21. Specific targeting of insect and vertebrate telomeres with pyrrole and imidazole polyamides. Maeshima, K., Janssen, S., Laemmli, U.K. EMBO J. (2001) [Pubmed]
  22. Nucleic acid-triggered catalytic drug release. Ma, Z., Taylor, J.S. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  23. Furan H2-antagonist ranitidine inhibits pentagastrin-stimulated gastric secretion stronger than cimetidine. Domschke, W., Lux, G., Domschke, S. Gastroenterology (1980) [Pubmed]
  24. Effects of myosin and heavy meromyosin on actin-related gelation of HeLa cell extracts. Weihing, R.R. J. Cell Biol. (1977) [Pubmed]
  25. Substrate-, hormone-, and cAMP-regulated cytochrome P450 degradation. Eliasson, E., Johansson, I., Ingelman-Sundberg, M. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  26. Immunochemical evidence for induction of the alcohol-oxidizing cytochrome P-450 of rabbit liver microsomes by diverse agents: ethanol, imidazole, trichloroethylene, acetone, pyrazole, and isoniazid. Koop, D.R., Crump, B.L., Nordblom, G.D., Coon, M.J. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  27. Use of terfenadine and contraindicated drugs. Thompson, D., Oster, G. JAMA (1996) [Pubmed]
  28. Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis. Brouard, S., Otterbein, L.E., Anrather, J., Tobiasch, E., Bach, F.H., Choi, A.M., Soares, M.P. J. Exp. Med. (2000) [Pubmed]
  29. Drug metabolism by rat and human hepatic microsomes in response to interaction with H2-receptor antagonists. Knodell, R.G., Holtzman, J.L., Crankshaw, D.L., Steele, N.M., Stanley, L.N. Gastroenterology (1982) [Pubmed]
  30. Azathioprine intolerance in patients with IBD may be imidazole-related and is independent of TPMT activity. McGovern, D.P., Travis, S.P., Duley, J., Shobowale-Bakre, e.l. .M., Dalton, H.R. Gastroenterology (2002) [Pubmed]
  31. Synthetic triterpenoids enhance transforming growth factor beta/Smad signaling. Suh, N., Roberts, A.B., Birkey Reffey, S., Miyazono, K., Itoh, S., ten Dijke, P., Heiss, E.H., Place, A.E., Risingsong, R., Williams, C.R., Honda, T., Gribble, G.W., Sporn, M.B. Cancer Res. (2003) [Pubmed]
  32. Up-regulation of cyclooxygenase-2 and apoptosis resistance by p38 MAPK in hypericin-mediated photodynamic therapy of human cancer cells. Hendrickx, N., Volanti, C., Moens, U., Seternes, O.M., de Witte, P., Vandenheede, J.R., Piette, J., Agostinis, P. J. Biol. Chem. (2003) [Pubmed]
  33. Characterization of inducible nitric-oxide synthase by cytochrome P-450 substrates and inhibitors. Inhibition by chlorzoxazone. Grant, S.K., Green, B.G., Wang, R., Pacholok, S.G., Kozarich, J.W. J. Biol. Chem. (1997) [Pubmed]
  34. Suppression by p38 MAP kinase inhibitors (pyridinyl imidazole compounds) of Ah receptor target gene activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin and the possible mechanism. Shibazaki, M., Takeuchi, T., Ahmed, S., Kikuchi, H. J. Biol. Chem. (2004) [Pubmed]
  35. Stimulation of MAPK cascades by insulin and osmotic shock: lack of an involvement of p38 mitogen-activated protein kinase in glucose transport in 3T3-L1 adipocytes. Kayali, A.G., Austin, D.A., Webster, N.J. Diabetes (2000) [Pubmed]
  36. A pH-sensitive histidine residue as control element for ligand release from HLA-DR molecules. Rötzschke, O., Lau, J.M., Hofstätter, M., Falk, K., Strominger, J.L. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  37. Immunological detection of aflatoxin B1-DNA adducts formed in vivo. Hsieh, L.L., Hsu, S.W., Chen, D.S., Santella, R.M. Cancer Res. (1988) [Pubmed]
  38. Effect of testosterone on imidazole-induced tyrosinase expression in B16 melanoma cell culture. Kline, E.L., Carland, K.C., Warren, J.T., Smith, T.J. Cancer Res. (1988) [Pubmed]
  39. Effects of imidazole derivatives on cytochromes P450 from human hepatocytes in primary culture. Maurice, M., Pichard, L., Daujat, M., Fabre, I., Joyeux, H., Domergue, J., Maurel, P. FASEB J. (1992) [Pubmed]
  40. Proton nuclear magnetic resonance study of the dynamic stability of the heme pocket of soybean leghemoglobin a. Exchange rates for the labile proton of the proximal histidyl imidazole. Kong, S.B., Cutnell, J.D., La Mar, G.N. J. Biol. Chem. (1983) [Pubmed]
WikiGenes - Universities