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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Conduritols as oviposition stimulants for the danaid butterfly, Parantica sita, identified from a host plant, Marsdenia tomentosa.

Host-plant chemicals responsible for egg-laying by the chestnut tiger butterfly, Parantica sita, were identified from one of its hosts, Marsdenia tomentosa. Ovipositing females responded positively to a methanolic extract of the plant. Solvent partitioning of the extract and oviposition bioassays indicated that the active principle resided in the aqueous fraction. Further activity-directed fractionation of the water-soluble constituents by various forms of column chromatography led to the isolation of several saturated and unsaturated cyclitols together with their glycosides. Of these, conduritol A, a predominant cyclitol present in the plant, moderately stimulated oviposition, while conduritol F 2-O-glucoside, although present in a very small amount, evoked a stronger response from females than conduritol A when tested at the same dose. In contrast, its aglycone, conduritol F, which was also a trace component, was almost inactive by itself. However, the oviposition-stimulatory activity of conduritol A was significantly enhanced when tested in combination with a small quantity of conduritol F. Addition of a small quantity of conduritol F 2-O-glucoside to conduritol A resulted in a substantial elevation in female responses. Consequently, the synergistic action of a large amount of conduritol A and small amounts of co-occurring conduritol F and its glucoside can account for the stimulation of egg-laying by P. sita on M. tomentosa.[1]


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