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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

AcrAB efflux pump plays a role in decreased susceptibility to tigecycline in Morganella morganii.

Transposon mutagenesis of a clinical isolate of Morganella morganii, G1492 (tigecycline MIC of 4 microg/ml), yielded two insertion knockout mutants for which tigecycline MICs were 0.03 microg/ml. Transposon insertions mapped to acrA, which is constitutively overexpressed in G1492, suggesting a role of the AcrAB efflux pump in decreased susceptibility to tigecycline in M. morganii.[1]

References

  1. AcrAB efflux pump plays a role in decreased susceptibility to tigecycline in Morganella morganii. Ruzin, A., Keeney, D., Bradford, P.A. Antimicrob. Agents Chemother. (2005) [Pubmed]
 
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