Chemical Compound Review:
Tygacil N-[(5aR,6aS,7S,9Z,10aS)-9- (amino-hydroxy...
Synonyms:
Livermore,
Woodford,
Breedt,
Teras,
Gardovskis,
Maritz,
Vaasna,
Ross,
Gioud-Paquet,
Dartois,
Ellis-Grosse,
Loh,
Ruzin,
Visalli,
Keeney,
Bradford,
Van Wart,
Owen,
Ludwig,
Meagher,
Korth-Bradley,
Cirincione,
Ruzin,
Keeney,
Bradford,
Rubinstein,
Vaughan,
McAleese,
Petersen,
Ruzin,
Dunman,
Murphy,
Projan,
Bradford,
Gales,
Jones,
Bradford,
Petersen,
Young,
Jones,
Tischler,
O'Connell,
Pachón-Ibáñez,
Jiménez-Mejías,
Pichardo,
Llanos,
Pachón,
Patel,
Rouse,
Piper,
Steckelberg,
Visalli,
Murphy,
Projan,
Bradford,
Wallace,
Brown-Elliott,
Crist,
Mann,
Wilson,
Meagher,
Ambrose,
Grasela,
Ellis-Grosse,
Jones,
Tuckman,
Howe,
Orlowski,
Mullen,
Chan,
Bradford,
Zhanel,
Homenuik,
Nichol,
Noreddin,
Vercaigne,
Embil,
Gin,
Karlowsky,
Hoban,
Petersen,
Bradford,
Weiss,
Murphy,
Sum,
Projan,
- The beta-lactamase threat in Enterobacteriaceae, Pseudomonas and Acinetobacter. Livermore, D.M., Woodford, N. Trends Microbiol. (2006)
- A novel MATE family efflux pump contributes to the reduced susceptibility of laboratory-derived Staphylococcus aureus mutants to tigecycline. McAleese, F., Petersen, P., Ruzin, A., Dunman, P.M., Murphy, E., Projan, S.J., Bradford, P.A. Antimicrob. Agents Chemother. (2005)
- Activity of tigecycline (GAR-936) against Acinetobacter baumannii strains, including those resistant to imipenem. Pachón-Ibáñez, M.E., Jiménez-Mejías, M.E., Pichardo, C., Llanos, A.C., Pachón, J. Antimicrob. Agents Chemother. (2004)
- Antibiotic coresistance in extended-spectrum-beta-lactamase-producing Enterobacteriaceae and in vitro activity of tigecycline. Morosini, M.I., García-Castillo, M., Coque, T.M., Valverde, A., Novais, A., Loza, E., Baquero, F., Cantón, R. Antimicrob. Agents Chemother. (2006)
- Impact of Enterococcus faecalis on the Bactericidal Activities of Arbekacin, Daptomycin, Linezolid, and Tigecycline against Methicillin-Resistant Staphylococcus aureus in a Mixed-Pathogen Pharmacodynamic Model. Laplante, K.L., Rybak, M.J., Leuthner, K.D., Chin, J.N. Antimicrob. Agents Chemother. (2006)
- Diagnostic PCR analysis of the occurrence of methicillin and tetracycline resistance genes among Staphylococcus aureus isolates from phase 3 clinical trials of tigecycline for complicated skin and skin structure infections. Jones, C.H., Tuckman, M., Howe, A.Y., Orlowski, M., Mullen, S., Chan, K., Bradford, P.A. Antimicrob. Agents Chemother. (2006)
- Population pharmacokinetics of tigecycline in patients with complicated intra-abdominal or skin and skin structure infections. Van Wart, S.A., Owen, J.S., Ludwig, E.A., Meagher, A.K., Korth-Bradley, J.M., Cirincione, B.B. Antimicrob. Agents Chemother. (2006)
- In vitro activities of ceftobiprole, tigecycline, daptomycin, and 19 other antimicrobials against methicillin-resistant Staphylococcus aureus strains from a national survey of Belgian hospitals. Denis, O., Deplano, A., Nonhoff, C., Hallin, M., De Ryck, R., Vanhoof, R., De Mendonça, R., Struelens, M.J. Antimicrob. Agents Chemother. (2006)
- Functional, biophysical, and structural bases for antibacterial activity of tigecycline. Olson, M.W., Ruzin, A., Feyfant, E., Rush, T.S., O'Connell, J., Bradford, P.A. Antimicrob. Agents Chemother. (2006)
- Activity of tigecycline (GAR-936), a novel glycylcycline, against Enterococci in the mouse peritonitis model. Nannini, E.C., Pai, S.R., Singh, K.V., Murray, B.E. Antimicrob. Agents Chemother. (2003)
- Comparative in vitro activities of GAR-936 against aerobic and anaerobic animal and human bite wound pathogens. Goldstein, E.J., Citron, D.M., Merriam, C.V., Warren, Y., Tyrrell, K. Antimicrob. Agents Chemother. (2000)
- Activities of tigecycline (GAR-936) against Legionella pneumophila in vitro and in guinea pigs with L. pneumophila pneumonia. Edelstein, P.H., Weiss, W.J., Edelstein, M.A. Antimicrob. Agents Chemother. (2003)
- In vitro and in vivo activities of tigecycline (GAR-936), daptomycin, and comparative antimicrobial agents against glycopeptide-intermediate Staphylococcus aureus and other resistant gram-positive pathogens. Petersen, P.J., Bradford, P.A., Weiss, W.J., Murphy, T.M., Sum, P.E., Projan, S.J. Antimicrob. Agents Chemother. (2002)
- Antimicrobial activity and spectrum of the new glycylcycline, GAR-936 tested against 1,203 recent clinical bacterial isolates. Gales, A.C., Jones, R.N. Diagn. Microbiol. Infect. Dis. (2000)
- Influence of transcriptional activator RamA on expression of multidrug efflux pump AcrAB and tigecycline susceptibility in Klebsiella pneumoniae. Ruzin, A., Visalli, M.A., Keeney, D., Bradford, P.A. Antimicrob. Agents Chemother. (2005)
- The glycylcyclines: a comparative review with the tetracyclines. Zhanel, G.G., Homenuik, K., Nichol, K., Noreddin, A., Vercaigne, L., Embil, J., Gin, A., Karlowsky, J.A., Hoban, D.J. Drugs (2004)
- Tigecycline MIC testing by broth dilution requires use of fresh medium or addition of the biocatalytic oxygen-reducing reagent oxyrase to standardize the test method. Bradford, P.A., Petersen, P.J., Young, M., Jones, C.H., Tischler, M., O'Connell, J. Antimicrob. Agents Chemother. (2005)
- AcrAB efflux pump plays a role in decreased susceptibility to tigecycline in Morganella morganii. Ruzin, A., Keeney, D., Bradford, P.A. Antimicrob. Agents Chemother. (2005)
- AcrAB multidrug efflux pump is associated with reduced levels of susceptibility to tigecycline (GAR-936) in Proteus mirabilis. Visalli, M.A., Murphy, E., Projan, S.J., Bradford, P.A. Antimicrob. Agents Chemother. (2003)
- Penetration, efflux and intracellular activity of tigecycline in human polymorphonuclear neutrophils (PMNs). Ong, C.T., Babalola, C.P., Nightingale, C.H., Nicolau, D.P. J. Antimicrob. Chemother. (2005)
- Serum, tissue and body fluid concentrations of tigecycline after a single 100 mg dose. Rodvold, K.A., Gotfried, M.H., Cwik, M., Korth-Bradley, J.M., Dukart, G., Ellis-Grosse, E.J. J. Antimicrob. Chemother. (2006)
- Comparative evaluation of tigecycline and vancomycin, with and without rifampicin, in the treatment of methicillin-resistant Staphylococcus aureus experimental osteomyelitis in a rabbit model. Yin, L.Y., Lazzarini, L., Li, F., Stevens, C.M., Calhoun, J.H. J. Antimicrob. Chemother. (2005)
- Pharmacokinetic/pharmacodynamic profile for tigecycline-a new glycylcycline antimicrobial agent. Meagher, A.K., Ambrose, P.G., Grasela, T.H., Ellis-Grosse, E.J. Diagn. Microbiol. Infect. Dis. (2005)
- Comparison of the in vitro activity of the glycylcycline tigecycline (formerly GAR-936) with those of tetracycline, minocycline, and doxycycline against isolates of nontuberculous mycobacteria. Wallace, R.J., Brown-Elliott, B.A., Crist, C.J., Mann, L., Wilson, R.W. Antimicrob. Agents Chemother. (2002)
- Safety and efficacy of tigecycline in treatment of skin and skin structure infections: results of a double-blind phase 3 comparison study with vancomycin-aztreonam. Breedt, J., Teras, J., Gardovskis, J., Maritz, F.J., Vaasna, T., Ross, D.P., Gioud-Paquet, M., Dartois, N., Ellis-Grosse, E.J., Loh, E. Antimicrob. Agents Chemother. (2005)
- Effects of efflux transporter genes on susceptibility of Escherichia coli to tigecycline (GAR-936). Hirata, T., Saito, A., Nishino, K., Tamura, N., Yamaguchi, A. Antimicrob. Agents Chemother. (2004)
- In vitro activity of GAR-936 against vancomycin-resistant enterococci, methicillin-resistant Staphylococcus aureus and penicillin-resistant Streptococcus pneumoniae. Patel, R., Rouse, M.S., Piper, K.E., Steckelberg, J.M. Diagn. Microbiol. Infect. Dis. (2000)
- Tigecycline is modified by the flavin-dependent monooxygenase TetX. Moore, I.F., Hughes, D.W., Wright, G.D. Biochemistry (2005)
- Tigecycline: a novel glycylcycline. Rubinstein, E., Vaughan, D. Drugs (2005)
- Use of ribotyping to retrospectively identify methicillin-resistant Staphylococcus aureus isolates from phase 3 clinical trials for tigecycline that are genotypically related to community-associated isolates. McAleese, F., Murphy, E., Babinchak, T., Singh, G., Said-Salim, B., Kreiswirth, B., Dunman, P., O'Connell, J., Projan, S.J., Bradford, P.A. Antimicrob. Agents Chemother. (2005)