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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Defibrillation effects of intravenous nifekalant in patients with out-of-hospital ventricular fibrillation.

Nifekalant (NF), a pure K(+) channel blocker developed in Japan, has been reported to be effective in the treatment of life-threatening ventricular arrhythmias. We studied its efficacy in 18 men and 4 women with out-of-hospital ventricular fibrillation (VF) admitted to our emergency department between August 2001 and March 2004. The number of DC shocks delivered for out-of-hospital VF, serum Na(+) and K(+), arterial blood pH, and base excess were compared in 8 patients treated with NF, 0.3 mg/kg i.v. followed by a continuous intravenous (group N) versus 14 patients treated with lidocaine, 2 mg/kg, i.v. (group C). The two groups were similar with respect to their baseline characteristics. Sinus rhythm returned in 5 of 8 patients in group N versus 2 of 14 patients in group C (P < 0.05). These seven patients were admitted to the intensive care unit, though all died within 1 month. The results of this study suggest that NF may be effective in defibrillation of out-of-hospital VF, though controlled studies are needed to confirm our observations.[1]


  1. Defibrillation effects of intravenous nifekalant in patients with out-of-hospital ventricular fibrillation. Igarashi, M., Fujino, T., Toyoda, M., Sugino, K., Sasao, K., Sasamoto, S., Otsuka, T., Kobayashi, K., Okano, Y., Yosiwara, K., Koyama, N. Pacing and clinical electrophysiology : PACE. (2005) [Pubmed]
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