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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Intensive Care

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Disease relevance of Intensive Care


Psychiatry related information on Intensive Care


High impact information on Intensive Care

  • There was no significant difference between the groups in mortality in the intensive care unit (ICU) (23.5 percent in the ranitidine group and 22.9 percent in the sucralfate group) or the duration of the stay in the ICU (median, nine days in both groups) [11].
  • An aerosol of polymyxin B was administered (2.5 mg per kilogram per day) to the upper airways of 292 patients in a respiratory-surgical intensive-care unit during a seven-month period, in an attempt to prevent Ps. aeruginosa pneumonia [12].
  • Should patients in intensive care units receive erythropoietin [13]?
  • JAMA patient page. Intensive care units [14].
  • We also searched EMBASE, HealthStar (Health Services, Technology, Administration, and Research), and HSRPROJ (Health Services Research Projects in Progress) via Internet Grateful Med and The Cochrane Library and hand searched abstract proceedings from intensive care national scientific meetings (January 1, 1994, through December 31, 2001) [15].

Chemical compound and disease context of Intensive Care


Biological context of Intensive Care


Anatomical context of Intensive Care


Associations of Intensive Care with chemical compounds

  • Contaminants were recovered less frequently from peripheral venous infusions (0.6%) than from infusions used for central venous access or hemodynamic monitoring (1.5%) or total parenteral nutrition (3.6%); infusions in an intensive care unit were more frequently contaminated (2.5%) than infusions on medical and surgical wards (0.9%) [31].
  • Two indices of free thyroxine (T4) and four methods of free T4 measurement were compared in 85 patients with acute illness, hospitalized in intensive care units [32].
  • How does blood glucose control with insulin save lives in intensive care [33]?
  • We suggest that propofol infusion at rates higher than 5 mg/kg per h should be discouraged for long-term sedation in the intensive-care unit [16].
  • METHODS: 328 patients admitted to 23 participating intensive-care units (ICUs) were randomly assigned a continuous intravenous infusion of low-dose dopamine (2 microg kg(-1) min(-1)) or placebo administered through a central venous catheter while in the ICU [34].

Gene context of Intensive Care

  • Arterial blood was serially sampled from admission (or at the start of elective operation) to day 13 in the intensive care unit, and the serum concentrations of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta, and IL-6 were determined [35].
  • All patients were to be treated to individual maximum tolerance of IL-2 at the intensive care unit level of support [36].
  • Plasma ACTH and cortisol concentrations are frequently elevated in patients in intensive care units (ICU) [37].
  • At intensive care admission, serum concentrations of 25(OH)D, 1,25 dihydroxyvitamin D(3), vitamin D-binding protein, ionized calcium, IL-1, and soluble IL-6-receptor were low, and PTH was normal [38].
  • We investigated the relation between CRP and its cytokine mediators in 64 critically ill patients during their treatment in the intensive-care unit [39].

Analytical, diagnostic and therapeutic context of Intensive Care


  1. Class restriction of cephalosporin use to control total cephalosporin resistance in nosocomial Klebsiella. Rahal, J.J., Urban, C., Horn, D., Freeman, K., Segal-Maurer, S., Maurer, J., Mariano, N., Marks, S., Burns, J.M., Dominick, D., Lim, M. JAMA (1998) [Pubmed]
  2. Hospital and 1-year survival of patients admitted to intensive care units with acute exacerbation of chronic obstructive pulmonary disease. Seneff, M.G., Wagner, D.P., Wagner, R.P., Zimmerman, J.E., Knaus, W.A. JAMA (1995) [Pubmed]
  3. Changing patterns of hip fracture care before and after implementation of the prospective payment system. Fitzgerald, J.F., Fagan, L.F., Tierney, W.M., Dittus, R.S. JAMA (1987) [Pubmed]
  4. Proteolytic inactivation of plasma C1- inhibitor in sepsis. Nuijens, J.H., Eerenberg-Belmer, A.J., Huijbregts, C.C., Schreuder, W.O., Felt-Bersma, R.J., Abbink, J.J., Thijs, L.G., Hack, C.E. J. Clin. Invest. (1989) [Pubmed]
  5. Comparison of propofol and midazolam for sedation in critically ill patients. Aitkenhead, A.R., Pepperman, M.L., Willatts, S.M., Coates, P.D., Park, G.R., Bodenham, A.R., Collins, C.H., Smith, M.B., Ledingham, I.M., Wallace, P.G. Lancet (1989) [Pubmed]
  6. Depressive symptoms in medical house officers. Effects of level of training and work rotation. Reuben, D.B. Arch. Intern. Med. (1985) [Pubmed]
  7. Effect of melatonin on sleep quality of COPD intensive care patients: a pilot study. Shilo, L., Dagan, Y., Smorjik, Y., Weinberg, U., Dolev, S., Komptel, B., Shenkman, L. Chronobiol. Int. (2000) [Pubmed]
  8. Rhabdomyolysis after correction of hyponatremia in psychogenic polydipsia possibly complicated by ziprasidone. Zaidi, A.N. The Annals of pharmacotherapy. (2005) [Pubmed]
  9. Carbohydrate-deficient transferrin for identification of drug overdose patients at risk of an alcohol withdrawal syndrome. Köppel, C., Müller, C., Wrobel, N. J. Toxicol. Clin. Toxicol. (1996) [Pubmed]
  10. Efficacy of an enteral 10-day methadone wean to prevent opioid withdrawal in fentanyl-tolerant pediatric intensive care unit patients. Meyer, M.M., Berens, R.J. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. (2001) [Pubmed]
  11. A comparison of sucralfate and ranitidine for the prevention of upper gastrointestinal bleeding in patients requiring mechanical ventilation. Canadian Critical Care Trials Group. Cook, D., Guyatt, G., Marshall, J., Leasa, D., Fuller, H., Hall, R., Peters, S., Rutledge, F., Griffith, L., McLellan, A., Wood, G., Kirby, A. N. Engl. J. Med. (1998) [Pubmed]
  12. Aerosol polymyxin and pneumonia in seriously ill patients. Feeley, T.W., Du Moulin, G.C., Hedley-Whyte, J., Bushnell, L.S., Gilbert, J.P., Feingold, D.S. N. Engl. J. Med. (1975) [Pubmed]
  13. Should patients in intensive care units receive erythropoietin? Carson, J.L. JAMA (2002) [Pubmed]
  14. JAMA patient page. Intensive care units. Stevens, L.M. JAMA (2002) [Pubmed]
  15. Physician staffing patterns and clinical outcomes in critically ill patients: a systematic review. Pronovost, P.J., Angus, D.C., Dorman, T., Robinson, K.A., Dremsizov, T.T., Young, T.L. JAMA (2002) [Pubmed]
  16. Long-term propofol infusion and cardiac failure in adult head-injured patients. Cremer, O.L., Moons, K.G., Bouman, E.A., Kruijswijk, J.E., de Smet, A.M., Kalkman, C.J. Lancet (2001) [Pubmed]
  17. Bioavailability of subcutaneous low-molecular-weight heparin to patients on vasopressors. Dörffler-Melly, J., de Jonge, E., Pont, A.C., Meijers, J., Vroom, M.B., Büller, H.R., Levi, M. Lancet (2002) [Pubmed]
  18. Multiple-dose activated charcoal for treatment of yellow oleander poisoning: a single-blind, randomised, placebo-controlled trial. de Silva, H.A., Fonseka, M.M., Pathmeswaran, A., Alahakone, D.G., Ratnatilake, G.A., Gunatilake, S.B., Ranasinha, C.D., Lalloo, D.G., Aronson, J.K., de Silva, H.J. Lancet (2003) [Pubmed]
  19. Oral disopyramide for the prevention of arrhythmias in patients with acute myocardial infarction admitted to open wards. Zainal, N., Carmichael, D.J., Griffiths, J.W., Besterman, E.M., Kidner, P.H., Gillham, A.D., Summers, G.D. Lancet (1977) [Pubmed]
  20. Hyperlipidemia and pancreatitis during pregnancy in two sisters with a mutation in the lipoprotein lipase gene. Keilson, L.M., Vary, C.P., Sprecher, D.L., Renfrew, R. Ann. Intern. Med. (1996) [Pubmed]
  21. Evaluation of the Pediatric Trauma Score. Kaufmann, C.R., Maier, R.V., Rivara, F.P., Carrico, C.J. JAMA (1990) [Pubmed]
  22. An outbreak of Burkholderia (formerly Pseudomonas) cepacia respiratory tract colonization and infection associated with nebulized albuterol therapy. Hamill, R.J., Houston, E.D., Georghiou, P.R., Wright, C.E., Koza, M.A., Cadle, R.M., Goepfert, P.A., Lewis, D.A., Zenon, G.J., Clarridge, J.E. Ann. Intern. Med. (1995) [Pubmed]
  23. Prevention of infection in critically ill patients by selective decontamination of the digestive tract. Cockerill, F.R., Muller, S.R., Anhalt, J.P., Marsh, H.M., Farnell, M.B., Mucha, P., Gillespie, D.J., Ilstrup, D.M., Larson-Keller, J.J., Thompson, R.L. Ann. Intern. Med. (1992) [Pubmed]
  24. Intraventricular hemorrhage in the high-risk preterm infant: incidence and outcome. Ahmann, P.A., Lazzara, A., Dykes, F.D., Brann, A.W., Schwartz, J.F. Ann. Neurol. (1980) [Pubmed]
  25. Oral nifedipine for the treatment of patients with severe hypertension. Davidson, R.C., Bursten, S.L., Keeley, P.A., Kenny, M.A., Stewart, D.K. Am. J. Med. (1985) [Pubmed]
  26. Hepatic failure in a patient taking rosiglitazone. Forman, L.M., Simmons, D.A., Diamond, R.H. Ann. Intern. Med. (2000) [Pubmed]
  27. The role of intragastric acidity and stress ulcus prophylaxis on colonization and infection in mechanically ventilated ICU patients. A stratified, randomized, double-blind study of sucralfate versus antacids. Bonten, M.J., Gaillard, C.A., van der Geest, S., van Tiel, F.H., Beysens, A.J., Smeets, H.G., Stobberingh, E.E. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  28. Colonization in patients receiving and not receiving topical antimicrobial prophylaxis. Bonten, M.J., Gaillard, C.A., Johanson, W.G., van Tiel, F.H., Smeets, H.G., van der Geest, S., Stobberingh, E.E. Am. J. Respir. Crit. Care Med. (1994) [Pubmed]
  29. Contribution of circulating lipids to the improved outcome of critical illness by glycemic control with intensive insulin therapy. Mesotten, D., Swinnen, J.V., Vanderhoydonc, F., Wouters, P.J., Van den Berghe, G. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  30. Plasma neopterin as an adjunct to C-reactive protein in assessment of infection. Sheldon, J., Riches, P.G., Soni, N., Jurges, E., Gore, M., Dadian, G., Hobbs, J.R. Clin. Chem. (1991) [Pubmed]
  31. Prospective study of replacing administration sets for intravenous therapy at 48- vs 72-hour intervals. 72 hours is safe and cost-effective. Maki, D.G., Botticelli, J.T., LeRoy, M.L., Thielke, T.S. JAMA (1987) [Pubmed]
  32. Free thyroxine levels in critically ill patients. A comparison of currently available assays. Slag, M.F., Morley, J.E., Elson, M.K., Labrosse, K.R., Crowson, T.W., Nuttall, F.Q., Shafer, R.B. JAMA (1981) [Pubmed]
  33. How does blood glucose control with insulin save lives in intensive care? Van den Berghe, G. J. Clin. Invest. (2004) [Pubmed]
  34. Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial. Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group. Bellomo, R., Chapman, M., Finfer, S., Hickling, K., Myburgh, J. Lancet (2000) [Pubmed]
  35. Cytokine patterns in patients after major vascular surgery, hemorrhagic shock, and severe blunt trauma. Relation with subsequent adult respiratory distress syndrome and multiple organ failure. Roumen, R.M., Hendriks, T., van der Ven-Jongekrijg, J., Nieuwenhuijzen, G.A., Sauerwein, R.W., van der Meer, J.W., Goris, R.J. Ann. Surg. (1993) [Pubmed]
  36. Prospective randomized trial of lisofylline for the prevention of toxicities of high-dose interleukin 2 therapy in advanced renal cancer and malignant melanoma. Margolin, K., Atkins, M., Sparano, J., Sosman, J., Weiss, G., Lotze, M., Doroshow, J., Mier, J., O'Boyle, K., Fisher, R., Campbell, E., Rubin, J., Federighi, D., Bursten, S. Clin. Cancer Res. (1997) [Pubmed]
  37. The hypothalamic-pituitary-adrenal axis in critical illness: response to dexamethasone and corticotropin-releasing hormone. Reincke, M., Allolio, B., Würth, G., Winkelmann, W. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  38. Bone turnover in prolonged critical illness: effect of vitamin D. Van den Berghe, G., Van Roosbroeck, D., Vanhove, P., Wouters, P.J., De Pourcq, L., Bouillon, R. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  39. C-reactive protein and its cytokine mediators in intensive-care patients. Sheldon, J., Riches, P., Gooding, R., Soni, N., Hobbs, J.R. Clin. Chem. (1993) [Pubmed]
  40. Control of endemic methicillin-resistant Staphylococcus aureus: a cost-benefit analysis in an intensive care unit. Chaix, C., Durand-Zaleski, I., Alberti, C., Brun-Buisson, C. JAMA (1999) [Pubmed]
  41. Alfentanil infusion for sedation and analgesia in intensive care. Yate, P.M., Thomas, D., Sebel, P.S. Lancet (1984) [Pubmed]
  42. Cimetidine for prevention and treatment of gastroduodenal mucosal lesions in patients in an intensive care unit. Peura, D.A., Johnson, L.F. Ann. Intern. Med. (1985) [Pubmed]
  43. Automated cardiac output measurement by spatiotemporal integration of color Doppler data. In vitro and clinical validation. Sun, J.P., Pu, M., Fouad, F.M., Christian, R., Stewart, W.J., Thomas, J.D. Circulation (1997) [Pubmed]
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