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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein.

An XWnt8-Fz5 fusion protein synergizes with LRP6 to potently activate beta-catenin-dependent signaling. Here, we generated a fusion in which XWnt8 was fused to the N-terminus of LRP6 and show it synergizes with both Fz4 and Fz5 to potently transactivate beta-catenin-dependent Wnt signaling. Based on this, we hypothesized that the main function of Wnt is to nucleate the formation of a physical complex between LRP6 and a Frizzled. Dkk1, but not the related Dkk3, binds LRP6 and inhibits canonical Wnt signaling by blocking the interaction of Wnt and LRP6. Therefore, we reasoned that a covalent fusion of Dkk1 to Fz5 (Dkk1-Fz5) would mimic Wnt ligand by nucleating the formation of a complex containing Fz5 and LRP6, while Dkk3 (Dkk3-Fz5) would not. We found that Dkk1-Fz5, but not Dkk3-Fz5, potently synergized with LRP6 to activate signaling in a dishevelled-dependent manner.[1]


  1. Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein. Holmen, S.L., Robertson, S.A., Zylstra, C.R., Williams, B.O. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
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