The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

DVL1  -  dishevelled segment polarity protein 1

Homo sapiens

Synonyms: DSH homolog 1, DVL, DVL1L1, DVL1P1, Dishevelled-1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of DVL1


Psychiatry related information on DVL1


High impact information on DVL1

  • In our analysis of signaling proteins containing DEP domains ( approximately 90 residue sequence motifs first recognized in fly Dishevelled, worm EGL-10, and mammalian Pleckstrin), we find that DEP domains are responsible for specific recognition of GPCRs [8].
  • The DIX domain targets dishevelled to actin stress fibres and vesicular membranes [9].
  • Here we describe the molecular characterization of members of the Wnt signalling pathway--Wnt, Dishevelled, GSK3, beta-Catenin and Tcf/Lef--in Hydra, a member of the evolutionarily old metazoan phylum Cnidaria [10].
  • Dishevelled is a conserved protein that interprets signals received by Frizzled receptors [11].
  • The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation [11].

Biological context of DVL1


Anatomical context of DVL1

  • Thus, our results suggest that an adverse interaction among misfolded SOD1, NEDL1, translocon-associated protein-delta, and Dishevelled-1 forms a ubiquitinated protein complex that is included in potentially cytotoxic protein aggregates and that mutually affects their functions, leading to motor neuron death in FALS [17].
  • Furthermore, we have shown that Dpr1 induces Dvl degradation via a lysosome inhibitor-sensitive and proteasome inhibitor-insensitive mechanism [18].
  • The structures do not localise with markers of the early or late endocytic pathway and time-lapse analysis demonstrates that Dvl-2 puncta move in a random fashion over short distances but do not originate from the plasma membrane [16].
  • In order to elucidate Dvl's role in Wnt signaling, we attempted to overexpress Dvl in cells, but were unable to obtain stable cell lines [19].
  • RESULTS: We report that Dsh protein accumulates in cell nuclei when Xenopus embryonic explants or mammalian cells are incubated with inhibitors of nuclear export or when a specific nuclear-export signal (NES) in Dsh is disrupted by mutagenesis [20].

Associations of DVL1 with chemical compounds

  • Which event(s) occur in Wnt-responsive cells depends critically on the ability of Dishevelled (Dsh)/Dvl proteins to interpret distinct types of intracellular, receptor-generated stimuli and transmit them to at least two distinct sets of effector molecules, all while apparently ignoring a third type of Wnt-generated Ca(2+) signal [21].
  • Redox-dependent activation of the Wnt-beta-catenin pathway occurs independently of extracellular Wnts and is impaired by RNAi of NRX . In addition, association between Dvl and NRX is inhibited by H(2)O(2) treatment [22].

Physical interactions of DVL1

  • WNT signals, transduced through Frizzled (FZD) receptors with extracellular WNT-binding domain and cytoplasmic Dishevelled-binding domain, are implicated in carcinogenesis and embryogenesis [23].

Other interactions of DVL1


Analytical, diagnostic and therapeutic context of DVL1

  • Two-hybrid screening for the physiological targets of NEDL1 has identified Dishevelled-1, one of the key transducers in the Wnt signaling pathway [17].
  • Low-pass filtering of the ECG produced a better correlation between tidal volume and the change in the DVL, when the cutoff frequency was set at 20-45 Hz [27].


  1. Prickle-1 Negatively Regulates Wnt/beta-Catenin Pathway by Promoting Dishevelled Ubiquitination/Degradation in Liver Cancer. Chan, D.W., Chan, C.Y., Yam, J.W., Ching, Y.P., Ng, I.O. Gastroenterology (2006) [Pubmed]
  2. Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cells. He, B., Lee, A.Y., Dadfarmay, S., You, L., Xu, Z., Reguart, N., Mazieres, J., Mikami, I., McCormick, F., Jablons, D.M. Cancer Res. (2005) [Pubmed]
  3. Activation of tumor-specific splice variant Rac1b by dishevelled promotes canonical Wnt signaling and decreased adhesion of colorectal cancer cells. Esufali, S., Charames, G.S., Pethe, V.V., Buongiorno, P., Bapat, B. Cancer Res. (2007) [Pubmed]
  4. Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression. Uematsu, K., He, B., You, L., Xu, Z., McCormick, F., Jablons, D.M. Oncogene (2003) [Pubmed]
  5. cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene. Pizzuti, A., Amati, F., Calabrese, G., Mari, A., Colosimo, A., Silani, V., Giardino, L., Ratti, A., Penso, D., Calzà, L., Palka, G., Scarlato, G., Novelli, G., Dallapiccola, B. Hum. Mol. Genet. (1996) [Pubmed]
  6. Identification of genomic organisation, sequence variants and analysis of the role of the human dishevelled 1 gene in late onset Alzheimer's disease. Russ, C., Lovestone, S., Powell, J.F. Mol. Psychiatry (2002) [Pubmed]
  7. The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity. Wallingford, J.B., Habas, R. Development (2005) [Pubmed]
  8. DEP-Domain-Mediated Regulation of GPCR Signaling Responses. Ballon, D.R., Flanary, P.L., Gladue, D.P., Konopka, J.B., Dohlman, H.G., Thorner, J. Cell (2006) [Pubmed]
  9. The DIX domain targets dishevelled to actin stress fibres and vesicular membranes. Capelluto, D.G., Kutateladze, T.G., Habas, R., Finkielstein, C.V., He, X., Overduin, M. Nature (2002) [Pubmed]
  10. WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra. Hobmayer, B., Rentzsch, F., Kuhn, K., Happel, C.M., von Laue, C.C., Snyder, P., Rothbächer, U., Holstein, T.W. Nature (2000) [Pubmed]
  11. The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation. Angers, S., Thorpe, C.J., Biechele, T.L., Goldenberg, S.J., Zheng, N., MacCoss, M.J., Moon, R.T. Nat. Cell Biol. (2006) [Pubmed]
  12. Mapping of candidate region for chordoma development to 1p36.13 by LOH analysis. Riva, P., Crosti, F., Orzan, F., Dalprà, L., Mortini, P., Parafioriti, A., Pollo, B., Fuhrman Conti, A.M., Miozzo, M., Larizza, L. Int. J. Cancer (2003) [Pubmed]
  13. Human dishevelled genes constitute a DHR-containing multigene family. Semënov, M.V., Snyder, M. Genomics (1997) [Pubmed]
  14. Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer. Katoh, Y., Katoh, M. Int. J. Oncol. (2007) [Pubmed]
  15. The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms. Wong, C.K., Luo, W., Deng, Y., Zou, H., Ye, Z., Lin, S.C. J. Biol. Chem. (2004) [Pubmed]
  16. Dishevelled (Dvl-2) activates canonical Wnt signalling in the absence of cytoplasmic puncta. Smalley, M.J., Signoret, N., Robertson, D., Tilley, A., Hann, A., Ewan, K., Ding, Y., Paterson, H., Dale, T.C. J. Cell. Sci. (2005) [Pubmed]
  17. NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1. Miyazaki, K., Fujita, T., Ozaki, T., Kato, C., Kurose, Y., Sakamoto, M., Kato, S., Goto, T., Itoyama, Y., Aoki, M., Nakagawara, A. J. Biol. Chem. (2004) [Pubmed]
  18. Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation. Zhang, L., Gao, X., Wen, J., Ning, Y., Chen, Y.G. J. Biol. Chem. (2006) [Pubmed]
  19. Transient overexpression of murine dishevelled genes results in apoptotic cell death. Strovel, E.T., Sussman, D.J. Exp. Cell Res. (1999) [Pubmed]
  20. Nuclear localization is required for Dishevelled function in Wnt/beta-catenin signaling. Itoh, K., Brott, B.K., Bae, G.U., Ratcliffe, M.J., Sokol, S.Y. J. Biol. (2005) [Pubmed]
  21. Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction. Wharton, K.A. Dev. Biol. (2003) [Pubmed]
  22. The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt-beta-catenin signalling through dishevelled. Funato, Y., Michiue, T., Asashima, M., Miki, H. Nat. Cell Biol. (2006) [Pubmed]
  23. Comparative genomics on Wnt3-Wnt9b gene cluster. Katoh, M. Int. J. Mol. Med. (2005) [Pubmed]
  24. Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase. Zhang, Y., Neo, S.Y., Han, J., Lin, S.C. J. Biol. Chem. (2000) [Pubmed]
  25. Secondary structure, 1H, 13C and 15N resonance assignments and molecular interactions of the dishevelled DIX domain. Capelluto, D.G., Overduin, M. J. Biochem. Mol. Biol. (2005) [Pubmed]
  26. Association of dishevelled with the clathrin ap-2 adaptor is required for frizzled endocytosis and planar cell polarity signaling. Yu, A., Rual, J.F., Tamai, K., Harada, Y., Vidal, M., He, X., Kirchhausen, T. Dev. Cell (2007) [Pubmed]
  27. Indirect measurement of tidal volume by multi-lead electrocardiograms: effect of filtering, deep breath, lead and posture. Noshiro, M., Inaoka, H., Yoshida, Y., Ryumae, S., Shimizu, M., Hoshino, H., Hosaka, H. Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering. (1996) [Pubmed]
WikiGenes - Universities