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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Courting a cure for fragile X.

Fragile X syndrome is the most common heritable cause of mental retardation. Previous work has suggested that overactive signaling by group I metabotropic glutamate receptors (mGluRs) may be a mechanism underlying many of the disease symptoms. As a test of this theory, McBride et al. show that in a Drosophila model for Fragile X syndrome, treatment with mGluR antagonists can rescue short-term memory, courtship, and mushroom body defects.[1]


  1. Courting a cure for fragile X. Dölen, G., Bear, M.F. Neuron (2005) [Pubmed]
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