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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The effect of age on vitamin E status, metabolism, and function: metabolism as assessed by labeled tocopherols.

The effects of age on vitamin E metabolism were studied in 97 healthy 20-75-year-old male nonsmoking Austrian volunteers of the VITAGE project. After a single oral intake of 30 mg d(6)-RRR-alpha- and d(2)-RRR-gamma-tocopheryl acetate, blood and 24-hour urine was collected. Deuterated tocopherols in plasma and deuterated urinary metabolites were analyzed by GC-MS. A first evaluation revealed a similar uptake of d(6)-alpha- and d(2)-gamma-tocopherol during the first 6 hours, and then d(2)-gamma-tocopherol started to decrease. Urinary d(2)-gamma- carboxyethyl hydroxychroman metabolites (CEHCs) exceeded those of d(6)-alpha-CEHCs by about 10 times. There was no effect of age. Thus, there might be no need for a higher vitamin E intake for healthy elderly nonsmoking men.[1]

References

  1. The effect of age on vitamin E status, metabolism, and function: metabolism as assessed by labeled tocopherols. Brigelius-Flohé, R., Roob, J.M., Tiran, B., Wuga, S., Ribalta, J., Rock, E., Winklhofer-Roob, B.M. Ann. N. Y. Acad. Sci. (2004) [Pubmed]
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