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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Quadruple-drug induction HAART in advanced HIV infection.

A randomized controlled study exploring an induction-maintenance strategy was performed with a quadruple-drug regimen: zidovudine/lamivudine/abacavir/nevirapine. The study was prematurely interrupted due to the high proportion of adverse events. The median time on protocol-defined therapy was 110 days; 13/28 (46%) patients interrupted therapy and 2/6 tested patients selected praecox viral mutants. Despite this, we observed a significant (p </= .001) increment of CD4. The theoretical advantages of induction-maintenance strategies are tempered by an increased risk of adverse experiences.[1]

References

  1. Quadruple-drug induction HAART in advanced HIV infection. Maggiolo, F., Ripamonti, D., Callegaro, A., Gregis, G., Quinzan, G., Suter, F. HIV clinical trials. (2005) [Pubmed]
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