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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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DNA immunization against respiratory syncytial virus (RSV) in infant rhesus monkeys.

A DNA vaccine was tested in infant Rhesus macaques to evaluate its safety, immunogenicity and protective efficacy. Monkeys were vaccinated and challenged with a clinical isolate of human RSV. Vaccinated animals developed humoral and cellular responses following inoculation with plasmid DNA encoding the fusion (F) and nucleoprotein ( N), from closely related bovine RSV. Vaccinated monkeys had decreased RSV in their lungs post-infection, and there was a qualitative difference in histopathology observed between vaccinated and unvaccinated animals. The combined result of safety and immunogenicity in a neonatal primate model is encouraging, suggesting the feasibility of DNA vaccines against RSV in infants.[1]

References

  1. DNA immunization against respiratory syncytial virus (RSV) in infant rhesus monkeys. Vaughan, K., Rhodes, G.H., Gershwin, L.J. Vaccine (2005) [Pubmed]
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