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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Macaca mulatta

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Disease relevance of Macaca mulatta


Psychiatry related information on Macaca mulatta


High impact information on Macaca mulatta

  • We developed an AIDS vaccine based on attenuated VSV vectors expressing env and gag genes and tested it in rhesus monkeys [11].
  • When rhesus monkeys were infected with a form of cloned SIVmac239 having a premature stop signal at the 93rd codon of nef, revertants with a coding codon at this position quickly and universally came to predominate in the infected animals [12].
  • We evaluated the ability of neonatal porcine islets to engraft and restore glucose control in pancreatectomized rhesus macaques [13].
  • Successful DNA immunization against measles: neutralizing antibody against either the hemagglutinin or fusion glycoprotein protects rhesus macaques without evidence of atypical measles [14].
  • We demonstrate here that administration of a CD154-specific monoclonal antibody (hu5C8) allows for renal allotransplantation in outbred, MHC-mismatched rhesus monkeys without acute rejection [15].

Chemical compound and disease context of Macaca mulatta


Biological context of Macaca mulatta


Anatomical context of Macaca mulatta


Associations of Macaca mulatta with chemical compounds


Gene context of Macaca mulatta

  • A rhesus monkey model to characterize the role of gastrin-releasing peptide (GRP) in lung development. Evidence for stimulation of airway growth [34].
  • We previously identified a novel nonclassical MHC class I molecule, Mamu-AG, which is expressed in the rhesus monkey placenta and shares many unique characteristics of HLA-G [35].
  • KD values of ezetimibe glucuronide for mouse, rat, rhesus monkey, and human NPC1L1 are 12,000, 540, 40, and 220 nM, respectively [36].
  • The administration of a CEA recombinant vaccine to rhesus monkeys induces both a humoral and a cell-mediated immune response directed against human CEA [37].
  • Taken together, these data suggest that convergent evolution may have resulted in the expression of a unique nonclassical MHC class I molecule in the rhesus monkey placenta, and that the common structural features of Mamu-AG and HLA-G may be functionally significant [38].

Analytical, diagnostic and therapeutic context of Macaca mulatta


  1. Functional recovery in parkinsonian monkeys treated with GDNF. Gash, D.M., Zhang, Z., Ovadia, A., Cass, W.A., Yi, A., Simmerman, L., Russell, D., Martin, D., Lapchak, P.A., Collins, F., Hoffer, B.J., Gerhardt, G.A. Nature (1996) [Pubmed]
  2. Use of a small molecule CCR5 inhibitor in macaques to treat simian immunodeficiency virus infection or prevent simian-human immunodeficiency virus infection. Veazey, R.S., Klasse, P.J., Ketas, T.J., Reeves, J.D., Piatak, M., Kunstman, K., Kuhmann, S.E., Marx, P.A., Lifson, J.D., Dufour, J., Mefford, M., Pandrea, I., Wolinsky, S.M., Doms, R.W., DeMartino, J.A., Siciliano, S.J., Lyons, K., Springer, M.S., Moore, J.P. J. Exp. Med. (2003) [Pubmed]
  3. Toxicity of chenodeoxycholic acid in the rhesus monkey. Dyrszka, H., Chen, T., Salen, G., Mosbach, E.H. Gastroenterology (1975) [Pubmed]
  4. Increased rates of CD4(+) and CD8(+) T lymphocyte turnover in simian immunodeficiency virus-infected macaques. Rosenzweig, M., DeMaria, M.A., Harper, D.M., Friedrich, S., Jain, R.K., Johnson, R.P. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  5. Trim5alpha protein restricts both HIV-1 and murine leukemia virus. Yap, M.W., Nisole, S., Lynch, C., Stoye, J.P. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  6. Choice behavior in rhesus monkeys: cocaine versus food. Aigner, T.G., Balster, R.L. Science (1978) [Pubmed]
  7. Intermittent thiamine deficiency in the rhesus monkey. II. Evidence for memory loss. Witt, E.D., Goldman-Rakic, P.S. Ann. Neurol. (1983) [Pubmed]
  8. Maternal absence and stability of individual differences in CSF 5-HIAA concentrations in rhesus monkey infants. Shannon, C., Schwandt, M.L., Champoux, M., Shoaf, S.E., Suomi, S.J., Linnoila, M., Higley, J.D. The American journal of psychiatry. (2005) [Pubmed]
  9. Chronic maternal nicotine exposure alters neuronal systems in the arcuate nucleus that regulate feeding behavior in the newborn rhesus macaque. Grove, K.L., Sekhon, H.S., Brogan, R.S., Keller, J.A., Smith, M.S., Spindel, E.R. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  10. Effects of mu opioid agonists alone and in combination with cocaine and D-amphetamine in rhesus monkeys trained to discriminate cocaine. Negus, S.S., Gatch, M.B., Mello, N.K. Neuropsychopharmacology (1998) [Pubmed]
  11. An effective AIDS vaccine based on live attenuated vesicular stomatitis virus recombinants. Rose, N.F., Marx, P.A., Luckay, A., Nixon, D.F., Moretto, W.J., Donahoe, S.M., Montefiori, D., Roberts, A., Buonocore, L., Rose, J.K. Cell (2001) [Pubmed]
  12. Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Kestler, H.W., Ringler, D.J., Mori, K., Panicali, D.L., Sehgal, P.K., Daniel, M.D., Desrosiers, R.C. Cell (1991) [Pubmed]
  13. Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways. Cardona, K., Korbutt, G.S., Milas, Z., Lyon, J., Cano, J., Jiang, W., Bello-Laborn, H., Hacquoil, B., Strobert, E., Gangappa, S., Weber, C.J., Pearson, T.C., Rajotte, R.V., Larsen, C.P. Nat. Med. (2006) [Pubmed]
  14. Successful DNA immunization against measles: neutralizing antibody against either the hemagglutinin or fusion glycoprotein protects rhesus macaques without evidence of atypical measles. Polack, F.P., Lee, S.H., Permar, S., Manyara, E., Nousari, H.G., Jeng, Y., Mustafa, F., Valsamakis, A., Adams, R.J., Robinson, H.L., Griffin, D.E. Nat. Med. (2000) [Pubmed]
  15. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. Kirk, A.D., Burkly, L.C., Batty, D.S., Baumgartner, R.E., Berning, J.D., Buchanan, K., Fechner, J.H., Germond, R.L., Kampen, R.L., Patterson, N.B., Swanson, S.J., Tadaki, D.K., TenHoor, C.N., White, L., Knechtle, S.J., Harlan, D.M. Nat. Med. (1999) [Pubmed]
  16. A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Burns, R.S., Chiueh, C.C., Markey, S.P., Ebert, M.H., Jacobowitz, D.M., Kopin, I.J. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  17. Fibrinogen receptor antagonist-induced thrombocytopenia in chimpanzee and rhesus monkey associated with preexisting drug-dependent antibodies to platelet glycoprotein IIb/IIIa. Bednar, B., Cook, J.J., Holahan, M.A., Cunningham, M.E., Jumes, P.A., Bednar, R.A., Hartman, G.D., Gould, R.J. Blood (1999) [Pubmed]
  18. Effect of treatment with aromatase inhibitor 4-hydroxandrostenedione on the nonhuman primate menstrual cycle. Brodie, A.M., Hammond, J.O., Ghosh, M., Meyer, K., Albrecht, E.D. Cancer Res. (1989) [Pubmed]
  19. Immunization of experimental animals with dihydrolipoamide acetyltransferase, as a purified recombinant polypeptide, generates mitochondrial antibodies but not primary biliary cirrhosis. Krams, S.M., Surh, C.D., Coppel, R.L., Ansari, A., Ruebner, B., Gershwin, M.E. Hepatology (1989) [Pubmed]
  20. Ovulation in rhesus monkeys suppressed by intranasal administration of progesterone and norethisterone. Anand Kumar, T.C., David, G.F., Puri, V. Nature (1977) [Pubmed]
  21. Association of simian immunodeficiency virus Nef with cellular serine/threonine kinases is dispensable for the development of AIDS in rhesus macaques. Lang, S.M., Iafrate, A.J., Stahl-Hennig, C., Kuhn, E.M., Nisslein, T., Kaup, F.J., Haupt, M., Hunsmann, G., Skowronski, J., Kirchhoff, F. Nat. Med. (1997) [Pubmed]
  22. Control of the rhesus monkey menstrual cycle: permissive role of hypothalamic gonadotropin-releasing hormone. Knobil, E., Plant, T.M., Wildt, L., Belchetz, P.E., Marshall, G. Science (1980) [Pubmed]
  23. D1 dopamine receptors in prefrontal cortex: involvement in working memory. Sawaguchi, T., Goldman-Rakic, P.S. Science (1991) [Pubmed]
  24. Medroxyprogesterone interferes with ovarian steroid protection against coronary vasospasm. Miyagawa, K., Rösch, J., Stanczyk, F., Hermsmeyer, K. Nat. Med. (1997) [Pubmed]
  25. Testosterone effects on the breast: implications for testosterone therapy for women. Somboonporn, W., Davis, S.R. Endocr. Rev. (2004) [Pubmed]
  26. Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey. Brozoski, T.J., Brown, R.M., Rosvold, H.E., Goldman, P.S. Science (1979) [Pubmed]
  27. Inhibition of gonadotropin by delta9-tetrahydrocannabinol:mediation by steroid receptors? Smith, R.G., Besch, N.F., Besch, P.K., Smith, C.G. Science (1979) [Pubmed]
  28. Transient synapses in the embryonic primate spinal cord. Knyihar, E., Csillik, B., Rakic, P. Science (1978) [Pubmed]
  29. Local paracrine effects of estradiol are central to parturition in the rhesus monkey. Nathanielsz, P.W., Jenkins, S.L., Tame, J.D., Winter, J.A., Guller, S., Giussani, D.A. Nat. Med. (1998) [Pubmed]
  30. Reduction of sexual interaction in rhesus monkeys by a vaginal action of progesterone. Baum, M.J., Everitt, B.J., Herbert, J., Keverne, E.B., de Greef, W.J. Nature (1976) [Pubmed]
  31. Ultradian rhythm of plasma noradrenaline in rhesus monkeys. Levin, B.E., Goldstein, A., Natelson, B.H. Nature (1978) [Pubmed]
  32. Production of premature delivery in pregnant rhesus monkeys by androstenedione infusion. Mecenas, C.A., Giussani, D.A., Owiny, J.R., Jenkins, S.L., Wu, W.X., Honnebier, B.O., Lockwood, C.J., Kong, L., Guller, S., Nathanielsz, P.W. Nat. Med. (1996) [Pubmed]
  33. Growth hormone treatment induces mammary gland hyperplasia in aging primates. Ng, S.T., Zhou, J., Adesanya, O.O., Wang, J., LeRoith, D., Bondy, C.A. Nat. Med. (1997) [Pubmed]
  34. A rhesus monkey model to characterize the role of gastrin-releasing peptide (GRP) in lung development. Evidence for stimulation of airway growth. Li, K., Nagalla, S.R., Spindel, E.R. J. Clin. Invest. (1994) [Pubmed]
  35. Placental expression of the nonclassical MHC class I molecule Mamu-AG at implantation in the rhesus monkey. Slukvin, I.I., Lunn, D.P., Watkins, D.I., Golos, T.G. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  36. The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1). Garcia-Calvo, M., Lisnock, J., Bull, H.G., Hawes, B.E., Burnett, D.A., Braun, M.P., Crona, J.H., Davis, H.R., Dean, D.C., Detmers, P.A., Graziano, M.P., Hughes, M., Macintyre, D.E., Ogawa, A., O'neill, K.A., Iyer, S.P., Shevell, D.E., Smith, M.M., Tang, Y.S., Makarewicz, A.M., Ujjainwalla, F., Altmann, S.W., Chapman, K.T., Thornberry, N.A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  37. Immunogenicity and safety of a recombinant vaccinia virus vaccine expressing the carcinoembryonic antigen gene in a nonhuman primate. Kantor, J., Irvine, K., Abrams, S., Snoy, P., Olsen, R., Greiner, J., Kaufman, H., Eggensperger, D., Schlom, J. Cancer Res. (1992) [Pubmed]
  38. Identification of a novel MHC class I gene, Mamu-AG, expressed in the placenta of a primate with an inactivated G locus. Boyson, J.E., Iwanaga, K.K., Golos, T.G., Watkins, D.I. J. Immunol. (1997) [Pubmed]
  39. Buprenorphine suppresses cocaine self-administration by rhesus monkeys. Mello, N.K., Mendelson, J.H., Bree, M.P., Lukas, S.E. Science (1989) [Pubmed]
  40. Molecular cloning of a retina-specific membrane guanylyl cyclase. Shyjan, A.W., de Sauvage, F.J., Gillett, N.A., Goeddel, D.V., Lowe, D.G. Neuron (1992) [Pubmed]
  41. Gastric protection by sucralfate. Role of mucus and prostaglandins. Shea-Donohue, T., Steel, L., Montcalm, E., Dubois, A. Gastroenterology (1986) [Pubmed]
  42. Long-term expression of human adenosine deaminase in rhesus monkeys transplanted with retrovirus-infected bone-marrow cells. van Beusechem, V.W., Kukler, A., Heidt, P.J., Valerio, D. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  43. Rapid mobilization of hematopoietic progenitor cells in rhesus monkeys by a single intravenous injection of interleukin-8. Laterveer, L., Lindley, I.J., Heemskerk, D.P., Camps, J.A., Pauwels, E.K., Willemze, R., Fibbe, W.E. Blood (1996) [Pubmed]
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