- CDK4 and MDM2 gene alterations mainly occur in highly proliferative and aggressive mantle cell lymphomas with wild-type INK4a/ARF locus. Hernández, L., Beà, S., Pinyol, M., Ott, G., Katzenberger, T., Rosenwald, A., Bosch, F., López-Guillermo, A., Delabie, J., Colomer, D., Montserrat, E., Campo, E. Cancer Res. (2005)