Gene Review:
CDK4 - cyclin-dependent kinase 4
Homo sapiens
Synonyms:
CMM3, Cell division protein kinase 4, Cyclin-dependent kinase 4, PSK-J3
- A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Serrano, M., Hannon, G.J., Beach, D. Nature (1993)
- CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis. Lazarov, M., Kubo, Y., Cai, T., Dajee, M., Tarutani, M., Lin, Q., Fang, M., Tao, S., Green, C.L., Khavari, P.A. Nat. Med. (2002)
- A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Wölfel, T., Hauer, M., Schneider, J., Serrano, M., Wölfel, C., Klehmann-Hieb, E., De Plaen, E., Hankeln, T., Meyer zum Büschenfelde, K.H., Beach, D. Science (1995)
- Aberrant expression of G1-phase cell cycle regulators in flat and exophytic adenomas of the human colon. Bartkova, J., Thullberg, M., Slezak, P., Jaramillo, E., Rubio, C., Thomassen, L.H., Bartek, J. Gastroenterology (2001)
- Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes. Korz, C., Pscherer, A., Benner, A., Mertens, D., Schaffner, C., Leupolt, E., Döhner, H., Stilgenbauer, S., Lichter, P. Blood (2002)
- Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease. McShea, A., Harris, P.L., Webster, K.R., Wahl, A.F., Smith, M.A. Am. J. Pathol. (1997)
- Multiple viral strategies of HTLV-1 for dysregulation of cell growth control. Yoshida, M. Annu. Rev. Immunol. (2001)
- A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Narita, M., Narita, M., Krizhanovsky, V., Nuñez, S., Chicas, A., Hearn, S.A., Myers, M.P., Lowe, S.W. Cell (2006)
- Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage. Agami, R., Bernards, R. Cell (2000)
- Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1. Harbour, J.W., Luo, R.X., Dei Santi, A., Postigo, A.A., Dean, D.C. Cell (1999)
- Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma. Zuo, L., Weger, J., Yang, Q., Goldstein, A.M., Tucker, M.A., Walker, G.J., Hayward, N., Dracopoli, N.C. Nat. Genet. (1996)
- Regulation of androgen-dependent prostatic cancer cell growth: androgen regulation of CDK2, CDK4, and CKI p16 genes. Lu, S., Tsai, S.Y., Tsai, M.J. Cancer Res. (1997)
- Novel mutations in the p16/CDKN2A binding region of the cyclin-dependent kinase-4 gene. Tsao, H., Benoit, E., Sober, A.J., Thiele, C., Haluska, F.G. Cancer Res. (1998)
- Analysis of the CDKN2A, CDKN2B and CDK4 genes in 48 Australian melanoma kindreds. Flores, J.F., Pollock, P.M., Walker, G.J., Glendening, J.M., Lin, A.H., Palmer, J.M., Walters, M.K., Hayward, N.K., Fountain, J.W. Oncogene (1997)
- Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation. Mukhopadhyay, A., Banerjee, S., Stafford, L.J., Xia, C., Liu, M., Aggarwal, B.B. Oncogene (2002)
- Induction of G1 phase arrest in MCF human breast cancer cells by pentagalloylglucose through the down-regulation of CDK4 and CDK2 activities and up-regulation of the CDK inhibitors p27(Kip) and p21(Cip). Chen, W.J., Chang, C.Y., Lin, J.K. Biochem. Pharmacol. (2003)
- Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Kato, J., Matsushime, H., Hiebert, S.W., Ewen, M.E., Sherr, C.J. Genes Dev. (1993)
- High frequency of multiple melanomas and breast and pancreas carcinomas in CDKN2A mutation-positive melanoma families. Borg, A., Sandberg, T., Nilsson, K., Johannsson, O., Klinker, M., Måsbäck, A., Westerdahl, J., Olsson, H., Ingvar, C. J. Natl. Cancer Inst. (2000)
- Physical interaction of human T-cell leukemia virus type 1 Tax with cyclin-dependent kinase 4 stimulates the phosphorylation of retinoblastoma protein. Haller, K., Wu, Y., Derow, E., Schmitt, I., Jeang, K.T., Grassmann, R. Mol. Cell. Biol. (2002)
- Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors". Bockstaele, L., Kooken, H., Libert, F., Paternot, S., Dumont, J.E., de Launoit, Y., Roger, P.P., Coulonval, K. Mol. Cell. Biol. (2006)
- Deregulation of the RB pathway in human testicular germ cell tumours. Bartkova, J., Lukas, C., Sørensen, C.S., Meyts, E.R., Skakkebaek, N.E., Lukas, J., Bartek, J. J. Pathol. (2003)
- Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells. Carlson, B.A., Dubay, M.M., Sausville, E.A., Brizuela, L., Worland, P.J. Cancer Res. (1996)
- Disruption of the cyclin D/cyclin-dependent kinase/INK4/retinoblastoma protein regulatory pathway in human neuroblastoma. Easton, J., Wei, T., Lahti, J.M., Kidd, V.J. Cancer Res. (1998)
- Expression of cyclin E renders cyclin D-CDK4 dispensable for inactivation of the retinoblastoma tumor suppressor protein, activation of E2F, and G1-S phase progression. Keenan, S.M., Lents, N.H., Baldassare, J.J. J. Biol. Chem. (2004)
- CDK4 expression and activity are required for cytokine responsiveness in T cells. Modiano, J.F., Mayor, J., Ball, C., Fuentes, M.K., Linthicum, D.S. J. Immunol. (2000)
- Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Alcorta, D.A., Xiong, Y., Phelps, D., Hannon, G., Beach, D., Barrett, J.C. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4. Leng, X., Noble, M., Adams, P.D., Qin, J., Harper, J.W. Mol. Cell. Biol. (2002)
- Identification of CDK4 sequences involved in cyclin D1 and p16 binding. Coleman, K.G., Wautlet, B.S., Morrissey, D., Mulheron, J., Sedman, S.A., Brinkley, P., Price, S., Webster, K.R. J. Biol. Chem. (1997)
- Involvement of G1/S cyclins in estrogen-independent proliferation of estrogen receptor-positive breast cancer cells. Bindels, E.M., Lallemand, F., Balkenende, A., Verwoerd, D., Michalides, R. Oncogene (2002)
- Transforming growth factor beta activates the promoter of cyclin-dependent kinase inhibitor p15INK4B through an Sp1 consensus site. Li, J.M., Nichols, M.A., Chandrasekharan, S., Xiong, Y., Wang, X.F. J. Biol. Chem. (1995)
- Biochemical characterizations reveal different properties between CDK4/cyclin D1 and CDK2/cyclin A. Kim, D.M., Yang, K., Yang, B.S. Exp. Mol. Med. (2003)
- Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D. Schmidt, M., Fernandez de Mattos, S., van der Horst, A., Klompmaker, R., Kops, G.J., Lam, E.W., Burgering, B.M., Medema, R.H. Mol. Cell. Biol. (2002)
- Limited redundancy in phosphorylation of retinoblastoma tumor suppressor protein by cyclin-dependent kinases in acute lymphoblastic leukemia. Schmitz, N.M., Hirt, A., Aebi, M., Leibundgut, K. Am. J. Pathol. (2006)
- Defining the substrate specificity of cdk4 kinase-cyclin D1 complex. Grafstrom, R.H., Pan, W., Hoess, R.H. Carcinogenesis (1999)
- Detection of p16 gene deletions in gliomas: a comparison of fluorescence in situ hybridization (FISH) versus quantitative PCR. Perry, A., Nobori, T., Ru, N., Anderl, K., Borell, T.J., Mohapatra, G., Feuerstein, B.G., Jenkins, R.B., Carson, D.A. J. Neuropathol. Exp. Neurol. (1997)
- Transforming growth factor B1 stimulated DNA synthesis in the granulosa cells of preantral follicles: negative interaction with epidermal growth factor. Yang, P., Roy, S.K. Biol. Reprod. (2006)
- Evidence for a cancer-specific switch at the CDK4 promoter with loss of control by both USF and c-Myc. Pawar, S.A., Szentirmay, M.N., Hermeking, H., Sawadogo, M. Oncogene (2004)
- Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells. Ramirez, R.D., Herbert, B.S., Vaughan, M.B., Zou, Y., Gandia, K., Morales, C.P., Wright, W.E., Shay, J.W. Oncogene (2003)
- Studies of variations of the cyclin-dependent kinase inhibitor 1C and the cyclin-dependent kinase 4 genes in relation to type 2 diabetes mellitus and related quantitative traits. Nielsen, E.M., Hansen, L., Stissing, T., Yanagisawa, K., Borch-Johnsen, K., Poulsen, P., Vaag, A., Hansen, T., Pedersen, O. J. Mol. Med. (2005)
- Mutations associated with familial melanoma impair p16INK4 function. Ranade, K., Hussussian, C.J., Sikorski, R.S., Varmus, H.E., Goldstein, A.M., Tucker, M.A., Serrano, M., Hannon, G.J., Beach, D., Dracopoli, N.C. Nat. Genet. (1995)
- Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1). Sugimoto, M., Nakamura, T., Ohtani, N., Hampson, L., Hampson, I.N., Shimamoto, A., Furuichi, Y., Okumura, K., Niwa, S., Taya, Y., Hara, E. Genes Dev. (1999)
- The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase. Baeg, G.H., Matsumine, A., Kuroda, T., Bhattacharjee, R.N., Miyashiro, I., Toyoshima, K., Akiyama, T. EMBO J. (1995)
- Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop. Garrett, S., Barton, W.A., Knights, R., Jin, P., Morgan, D.O., Fisher, R.P. Mol. Cell. Biol. (2001)
- CDK4 and MDM2 gene alterations mainly occur in highly proliferative and aggressive mantle cell lymphomas with wild-type INK4a/ARF locus. Hernández, L., Beà, S., Pinyol, M., Ott, G., Katzenberger, T., Rosenwald, A., Bosch, F., López-Guillermo, A., Delabie, J., Colomer, D., Montserrat, E., Campo, E. Cancer Res. (2005)
- Coordinated expression and amplification of the MDM2, CDK4, and HMGI-C genes in atypical lipomatous tumours. Dei Tos, A.P., Doglioni, C., Piccinin, S., Sciot, R., Furlanetto, A., Boiocchi, M., Dal Cin, P., Maestro, R., Fletcher, C.D., Tallini, G. J. Pathol. (2000)
- An NF-kappaB-specific inhibitor, IkappaBalpha, binds to and inhibits cyclin-dependent kinase 4. Li, J., Joo, S.H., Tsai, M.D. Biochemistry (2003)
- Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A). Li, J., Muscarella, P., Joo, S.H., Knobloch, T.J., Melvin, W.S., Weghorst, C.M., Tsai, M.D. Biochemistry (2005)