Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gonzalez-Angulo, A.M. et al.

Gonzalez-Angulo, Broglio, Kau, Eralp, Erlichman, Valero, Theriault, Booser, Buzdar, Hortobagyi, Arun,

Women age < or = 35 years with primary breast carcinoma: disease features at presentation.

BACKGROUND: The purpose of the current study was to describe a population of young patients with breast carcinoma, their characteristics at the time of diagnosis, and the association of these characteristics with disease recurrence and survival. METHODS: Four hundred fifty-two women age < or = 35 years with breast carcinoma were registered at The University of Texas M. D. Anderson Cancer Center (Houston, TX) between 1990 and 2002. The relation between clinicopathologic factors and disease recurrence-free survival (RFS) and overall survival (OS) was assessed. Cox regression analysis was used to identify independent survival predictors. RESULTS: The median age of the patients was 32 years. Most of the patients were white, and 20% were obese. Approximately 50% reported oral contraceptive use, 34% reported a family history of breast carcinoma, and 5% reported a family history of ovarian carcinoma. Sixty-nine percent of tumors were nuclear Grade 3 (using the modified Black's nuclear grading system), 52% had positive estrogen receptors, and 48% had positive progesterone receptors. HER-2/neu status was available in 60% of tumor specimens and 34% were HER-2/neu positive. The median follow-up was 36 months. There were 185 disease recurrences and 84 deaths. RFS was significantly shorter in patients who reported a family history of ovarian carcinoma (P < 0.0001) and in those who had hormone receptor-negative tumor specimens (P = 0.001). OS was significantly shorter in patients who reported a family history of ovarian carcinoma (P = 0.001), those who had hormone receptor-negative tumor specimens (P < 0.0001), or those with > nuclear Grade 3 tumor specimens (P = 0.005). CONCLUSIONS: This young population with breast carcinoma was found to have more aggressive biologic features. Hormone receptor negativity and a family history of ovarian carcinoma were associated with shorter RFS and OS.[1]

References

Women age < or = 35 years with primary breast carcinoma: disease features at presentation. Gonzalez-Angulo, A.M., Broglio, K., Kau, S.W., Eralp, Y., Erlichman, J., Valero, V., Theriault, R., Booser, D., Buzdar, A.U., Hortobagyi, G.N., Arun, B. Cancer (2005) [Pubmed]

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