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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The stabilization of housekeeping transcripts in Trypanosoma cruzi epimastigotes evidences a global regulation of RNA decay during stationary phase.

The relative steady state concentration of mRNAs of four housekeeping single-copy type Trypanosoma cruzi genes ( actin, triosephosphate isomerase, trypanothion reductase and the ribosomal protein S4) was analyzed throughout the growth curve. A distinguishable pattern was observed with maximal levels occurring at the logarithmic phase of growth and minimum levels occurring at the stationary phase. The half-lives of all analyzed messenger RNAs, and also of three molecular species of immature ribosomal RNAs were increased in cells isolated from stationary phase. These results suggest the occurrence of a novel global regulation mechanism that might protect transcripts from degradation in stationary epimastigotes, probably as a strategy to perpetuate through this quiescent stage.[1]

References

  1. The stabilization of housekeeping transcripts in Trypanosoma cruzi epimastigotes evidences a global regulation of RNA decay during stationary phase. Cevallos, A.M., Pérez-Escobar, M., Espinosa, N., Herrera, J., López-Villaseñor, I., Hernández, R. FEMS Microbiol. Lett. (2005) [Pubmed]
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