- The talinolol double-peak phenomenon is likely caused by presystemic processing after uptake from gut lumen. Weitschies, W., Bernsdorf, A., Giessmann, T., Zschiesche, M., Modess, C., Hartmann, V., Mrazek, C., Wegner, D., Nagel, S., Siegmund, W. Pharm. Res. (2005)