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Chemical Compound Review

AGN-PC-00KGOW     [3,7-dimethyl-9-(2,6,6- trimethyl-1...

Synonyms: KBioGR_000891, KBioSS_002317, NINDS_000249, SPBio_001468, AC1L1JIR, ...
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Disease relevance of Aquasol A


High impact information on Aquasol A

  • The retinyl palmitate fat tolerance test was used to measure chylomicron remnant clearance in 10 normal subjects (apolipoprotein E [apo E] isotypes 3 or 4 only), 6 normolipidemic apo E2/2 homozygotes and 5 familial hypercholesterolemic homozygotes [6].
  • We have examined the effect of the apo E polymorphism on dietary fat clearance using the vitamin A-fat loading test, which specifically labels intestinally derived lipoproteins with retinyl palmitate (RP) [7].
  • Compared with E3/3 subjects, E3/2 subjects had a significantly higher nonchylomicron RP concentration (P less than 0.05) (peak heights and areas below the curves) indicating slower clearance and the E4/3, E4/4 group had a significantly lower nonchylomicron RP concentration (P less than 0.05) indicating faster clearance [7].
  • Adjuvant effect of vitamin A palmitate and analogs on cell-mediated immunity [8].
  • However, despite this effect on postprandial retinyl palmitate, the profile of postprandial triglyceride response was not significantly different among apo E genotypes [9].

Chemical compound and disease context of Aquasol A


Biological context of Aquasol A


Anatomical context of Aquasol A


Associations of Aquasol A with other chemical compounds


Gene context of Aquasol A


Analytical, diagnostic and therapeutic context of Aquasol A


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  2. Antipyretic and antiviral action of vitamin A in Moloney sarcoma virus- and poxvirus-inoculated mice. Seifter, E., Rettura, G., Padawer, J., Demetriou, A.A., Levenson, S. J. Natl. Cancer Inst. (1976) [Pubmed]
  3. Combined treatments with vitamin A and 5-fluorouracil and the growth of allotransplantable and syngeneic tumors in mice. Tomita, Y., Himeno, K., Nomoto, K., Endo, H., Hirohata, T. J. Natl. Cancer Inst. (1982) [Pubmed]
  4. Catabolism of chylomicron remnants in patients with previous acute pancreatitis. Rollán, A., Guzmán, S., Pimentel, F., Nervi, F. Gastroenterology (1990) [Pubmed]
  5. Lung cancer chemoprevention: an integrated approach. Lippman, S.M., Spitz, M.R. J. Clin. Oncol. (2001) [Pubmed]
  6. Chylomicron remnant clearance from the plasma is normal in familial hypercholesterolemic homozygotes with defined receptor defects. Rubinsztein, D.C., Cohen, J.C., Berger, G.M., van der Westhuyzen, D.R., Coetzee, G.A., Gevers, W. J. Clin. Invest. (1990) [Pubmed]
  7. Dietary fat clearance in normal subjects is regulated by genetic variation in apolipoprotein E. Weintraub, M.S., Eisenberg, S., Breslow, J.L. J. Clin. Invest. (1987) [Pubmed]
  8. Adjuvant effect of vitamin A palmitate and analogs on cell-mediated immunity. Athanassiades, T.J. J. Natl. Cancer Inst. (1981) [Pubmed]
  9. Apolipoprotein E polymorphism influences postprandial retinyl palmitate but not triglyceride concentrations. Boerwinkle, E., Brown, S., Sharrett, A.R., Heiss, G., Patsch, W. Am. J. Hum. Genet. (1994) [Pubmed]
  10. Retinyl palmitate, retinyl phosphate, and dolichyl phosphate of postnuclear membrane fraction from hepatoma, host liver, and regenerating liver: marginal vitamin A status of hepatoma tissue. De Luca, L.M., Brugh, M., Silverman-Jones, C.S. Cancer Res. (1984) [Pubmed]
  11. Vitamin A absorption in cystic fibrosis: risk of hypervitaminosis A. James, D.R., Owen, G., Campbell, I.A., Goodchild, M.C. Gut (1992) [Pubmed]
  12. Association of postprandial triglyceride and retinyl palmitate responses with newly diagnosed exercise-induced myocardial ischemia in middle-aged men and women. Ginsberg, H.N., Jones, J., Blaner, W.S., Thomas, A., Karmally, W., Fields, L., Blood, D., Begg, M.D. Arterioscler. Thromb. Vasc. Biol. (1995) [Pubmed]
  13. Effect to tween 80 and aquasol A on virus plaque formation. Blalock, J.E., Tullish, J., Gifford, G.E. Infect. Immun. (1975) [Pubmed]
  14. The association between participant characteristics and serum concentrations of beta-carotene, retinol, retinyl palmitate, and alpha-tocopherol among participants in the Carotene and Retinol Efficacy Trial (CARET) for prevention of lung cancer. Goodman, G.E., Thornquist, M., Kestin, M., Metch, B., Anderson, G., Omenn, G.S. Cancer Epidemiol. Biomarkers Prev. (1996) [Pubmed]
  15. Hydrolysis of 11-cis- and all-trans-retinyl palmitate by retinal pigment epithelium microsomes. Mata, N.L., Tsin, A.T., Chambers, J.P. J. Biol. Chem. (1992) [Pubmed]
  16. Purification and characterization of a neutral, bile salt-independent retinyl ester hydrolase from rat liver microsomes. Relationship To rat carboxylesterase ES-2. Sun, G., Alexson, S.E., Harrison, E.H. J. Biol. Chem. (1997) [Pubmed]
  17. Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells. Hazra, S., Xiong, S., Wang, J., Rippe, R.A., Krishna, V., Chatterjee, K., Tsukamoto, H. J. Biol. Chem. (2004) [Pubmed]
  18. Retinol esterification by rat liver microsomes. Evidence for a fatty acyl coenzyme A: retinol acyltransferase. Ross, A.C. J. Biol. Chem. (1982) [Pubmed]
  19. CoA- and non-CoA-dependent retinol esterification in retinal pigment epithelium. Saari, J.C., Bredberg, D.L. J. Biol. Chem. (1988) [Pubmed]
  20. Hydrolysis of 11-cis- and all-trans-retinyl palmitate by homogenates of human retinal epithelial cells. Blaner, W.S., Das, S.R., Gouras, P., Flood, M.T. J. Biol. Chem. (1987) [Pubmed]
  21. Morphologic alterations in the trachea and the salivary gland following the induction of rapid synchronous vitamin A deficiency in rats. Anzano, M.A., Olson, J.A., Lamb, A.J. Am. J. Pathol. (1980) [Pubmed]
  22. Hydrolysis of retinyl palmitate by enzymes of rat pancreas and liver. Differentiation of bile salt-dependent and bile salt-independent, neutral retinyl ester hydrolases in rat liver. Harrison, E.H., Gad, M.Z. J. Biol. Chem. (1989) [Pubmed]
  23. Enzymatic conversion of all-trans-beta-carotene to retinal by a cytosolic enzyme from rabbit and rat intestinal mucosa. Lakshman, M.R., Mychkovsky, I., Attlesey, M. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  24. Retinol metabolism in LLC-PK1 Cells. Characterization of retinoic acid synthesis by an established mammalian cell line. Napoli, J.L. J. Biol. Chem. (1986) [Pubmed]
  25. Retinoic acid-binding protein in rat tissue. Partial purification and comparison to rat tissue retinol-binding protein. Ong, D.E., Chytil, F. J. Biol. Chem. (1975) [Pubmed]
  26. Rpe65 is a retinyl ester binding protein that presents insoluble substrate to the isomerase in retinal pigment epithelial cells. Mata, N.L., Moghrabi, W.N., Lee, J.S., Bui, T.V., Radu, R.A., Horwitz, J., Travis, G.H. J. Biol. Chem. (2004) [Pubmed]
  27. RPE65 operates in the vertebrate visual cycle by stereospecifically binding all-trans-retinyl esters. Gollapalli, D.R., Maiti, P., Rando, R.R. Biochemistry (2003) [Pubmed]
  28. Postabsorptive retinyl palmitate removal is retarded in lecithin-cholesterol acyltransferase deficiency. Gylling, H., Miettinen, T.A. Eur. J. Clin. Invest. (1993) [Pubmed]
  29. Cellular retinol-binding protein in mucosa, in benign and malignant non-squamous cell tumours of the head and neck. Wahlberg, P., Fex, G., Wennerberg, J., Willén, R. Acta Otolaryngol. (1989) [Pubmed]
  30. Pancreatic lipase and pancreatic lipase-related protein 2, but not pancreatic lipase-related protein 1, hydrolyze retinyl palmitate in physiological conditions. Reboul, E., Berton, A., Moussa, M., Kreuzer, C., Crenon, I., Borel, P. Biochim. Biophys. Acta (2006) [Pubmed]
  31. EUROSCAN, a randomized trial of vitamin A and N-acetylcysteine in patients with head and neck cancer or lung cancer. For the EUropean Organization for Research and Treatment of Cancer Head and Neck and Lung Cancer Cooperative Groups. van Zandwijk, N., Dalesio, O., Pastorino, U., de Vries, N., van Tinteren, H. J. Natl. Cancer Inst. (2000) [Pubmed]
  32. Vitamin A antagonizes calcium response to vitamin D in man. Johansson, S., Melhus, H. J. Bone Miner. Res. (2001) [Pubmed]
  33. Serum retinoids and beta-carotene as predictors of hip and other fractures in elderly women. Barker, M.E., McCloskey, E., Saha, S., Gossiel, F., Charlesworth, D., Powers, H.J., Blumsohn, A. J. Bone Miner. Res. (2005) [Pubmed]
  34. Daily consumption of Indian spinach (Basella alba) or sweet potatoes has a positive effect on total-body vitamin A stores in Bangladeshi men. Haskell, M.J., Jamil, K.M., Hassan, F., Peerson, J.M., Hossain, M.I., Fuchs, G.J., Brown, K.H. Am. J. Clin. Nutr. (2004) [Pubmed]
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