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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Monoamine oxidase inhibitory naphthoquinones from the roots of Lithospermum erythrorhizon.

Activity-guided fractionation of a hexane-soluble extract of the roots of Lithospermum erythrorhizon, using a mouse brain monoamine oxidase (MAO) inhibition assay, led to the isolation of two known naphthoquinones, acetylshikonin and shikonin, and a furylhydroquinone, shikonofuran E. These compounds were shown to inhibit MAO with IC50 values of 10.0, 13.3, and 59.1 microM, respectively. Although no specificity for MAO-A and MAO-B was shown by acetylshikonin and shikonin, a Lineweaver-Burk plot analysis indicated that the inhibition was competitive for both MAO-A and MAO-B activity.[1]

References

  1. Monoamine oxidase inhibitory naphthoquinones from the roots of Lithospermum erythrorhizon. Choi, W.H., Hong, S.S., Lee, S.A., Han, X.H., Lee, K.S., Lee, M.K., Hwang, B.Y., Ro, J.S. Arch. Pharm. Res. (2005) [Pubmed]
 
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