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Chemical Compound Review

Acetylshikonin     [(1R)-1-(5,8-dihydroxy-1,4- dioxo...

Synonyms: CHEMBL403516, SureCN219826, CHEBI:104991, KST-1B2174, AC-20169, ...
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Disease relevance of AIDS094457

  • Inhibition of hind-paw edema and cutaneous vascular plasma extravasation in mice by acetylshikonin [1].
  • This study has demonstrated that acetylshikonin (ACS), the isolated ingredient from Lithospermum canescens Lehm. roots, in a daily dose of 200 microg for 3 days, inhibited cutaneous angiogenesis induced by L-1 sarcoma cells in Balb/c mice [2].

High impact information on AIDS094457


Biological context of AIDS094457


Anatomical context of AIDS094457


Associations of AIDS094457 with other chemical compounds


Gene context of AIDS094457

  • 5. Both the neutrophil cytosolic protein kinase C (PKC) activity and the PMA-induced PKC associated with the membrane were unaffected by acetylshikonin [3].


  1. Inhibition of hind-paw edema and cutaneous vascular plasma extravasation in mice by acetylshikonin. Wang, J.P., Raung, S.L., Chang, L.C., Kuo, S.C. Eur. J. Pharmacol. (1995) [Pubmed]
  2. The effect of acetylshikonin isolated from Lithospermum canescens roots on tumor-induced cutaneous angiogenesis. Pietrosiuk, A., Furmanowa, M., Skopińiska-Rózewska, E., Sommer, E., Skurzak, H., Bany, J. Acta poloniae pharmaceutica. (2004) [Pubmed]
  3. Investigation of the inhibition by acetylshikonin of the respiratory burst in rat neutrophils. Wang, J.P., Tsao, L.T., Raung, S.L., Hsu, M.F., Kuo, S.C. Br. J. Pharmacol. (1997) [Pubmed]
  4. Impairment of phosphatidylinositol signaling in acetylshikonin-treated neutrophils. Wang, J.P., Kuo, S.C. Biochem. Pharmacol. (1997) [Pubmed]
  5. Inhibition on platelet activation by shikonin derivatives isolated from Arnebia euchroma. Ko, F.N., Lee, Y.S., Kuo, S.C., Chang, Y.S., Teng, C.M. Biochim. Biophys. Acta (1995) [Pubmed]
  6. Simultaneous analysis of shikimate-derived secondary metabolites in Lithospermum erythrorhizon cell suspension cultures by high-performance liquid chromatography. Yamamoto, H., Yazaki, K., Inoue, K. J. Chromatogr. B Biomed. Sci. Appl. (2000) [Pubmed]
  7. Accelerative effect of shikonin, alkannin and acetylshikonin on the proliferation of granulation tissue in rats. Ozaki, Y., Ohno, A., Saito, Y., Satake, M. Biol. Pharm. Bull. (1994) [Pubmed]
  8. Inhibitory effect of acetylshikonin on the activation of NADPH oxidase in polymorphonuclear leukocytes in both whole cell and cell-free systems. Kawakami, N., Koyama, Y., Tanaka, J., Ohara, A., Hayakawa, T., Fujimoto, S. Biol. Pharm. Bull. (1996) [Pubmed]
  9. Monoamine oxidase inhibitory naphthoquinones from the roots of Lithospermum erythrorhizon. Choi, W.H., Hong, S.S., Lee, S.A., Han, X.H., Lee, K.S., Lee, M.K., Hwang, B.Y., Ro, J.S. Arch. Pharm. Res. (2005) [Pubmed]
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