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Gene Review

Maob  -  monoamine oxidase B

Mus musculus

Synonyms: 6330414K01Rik, MAO-B, Monoamine oxidase type B
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Disease relevance of Maob


Psychiatry related information on Maob


High impact information on Maob


Chemical compound and disease context of Maob


Biological context of Maob


Anatomical context of Maob


Associations of Maob with chemical compounds

  • Striatal dopamine metabolism in monoamine oxidase B-deficient mice: a brain dialysis study [23].
  • Also of interest is the decrease of liver MAO-B in old animals, which, together with the increase of MAO-B in the brain, might underlie the high sensitivity of old BL/C57 mice to MPTP [21].
  • Different from MPTP, however, neither the inhibition of MAO B (selegiline) nor MAO A (clorgiline) blocked the dopamine-depleting effects of 2'CH3-MPTP; rather, the simultaneous inhibition of both forms of the enzyme was required [24].
  • To characterize the involvement of MAO B further in the age-related effects of MPTP, a neurotoxic analog of MPTP, 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine (2'CH3-MPTP), was used [24].
  • The neurotoxicity of MPTP is dependent upon its monoamine oxidase-B (MAO-B)-catalyzed conversion to the 1-methyl-4-phenylpyridinium species (MPP+) [1].

Regulatory relationships of Maob


Other interactions of Maob


Analytical, diagnostic and therapeutic context of Maob


  1. Role for monoamine oxidase-A (MAO-A) in the bioactivation and nigrostriatal dopaminergic neurotoxicity of the MPTP analog, 2'Me-MPTP. Kindt, M.V., Youngster, S.K., Sonsalla, P.K., Duvoisin, R.C., Heikkila, R.E. Eur. J. Pharmacol. (1988) [Pubmed]
  2. Effects of angiotensin II on brain monoamine oxidase activity in non-hypoxic and hypoxic mice. Stancheva, S., Georgiev, V., Alova, L., Getova, D. Acta physiologica et pharmacologica Bulgarica. (1996) [Pubmed]
  3. Development of fluorinated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs with potent nigrostriatal toxicity for potential use in positron emission tomography studies. Harik, S.I., Riachi, N.J., Hritz, M.A., Berridge, M.S., Sayre, L.M. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  4. MAO inhibitors, clorgyline and lazabemide, prevent hydroxyl radical generation caused by brain ischemia/reperfusion in mice. Suzuki, T., Akaike, N., Ueno, K., Tanaka, Y., Himori, N. Pharmacology (1995) [Pubmed]
  5. Neuroprotective effect of rasagiline, a selective monoamine oxidase-B inhibitor, against closed head injury in the mouse. Huang, W., Chen, Y., Shohami, E., Weinstock, M. Eur. J. Pharmacol. (1999) [Pubmed]
  6. MAO-B knockout mice exhibit deficient habituation of locomotor activity but normal nicotine intake. Lee, M., Chen, K., Shih, J.C., Hiroi, N. Genes Brain Behav. (2004) [Pubmed]
  7. Protective effect of L-deprenyl against apoptosis induced by okadaic acid in cultured neuronal cells. Suuronen, T., Kolehmainen, P., Salminen, A. Biochem. Pharmacol. (2000) [Pubmed]
  8. Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors. Heikkila, R.E., Manzino, L., Cabbat, F.S., Duvoisin, R.C. Nature (1984) [Pubmed]
  9. Serotonin uptake, storage, and synthesis in an immortalized committed cell line derived from mouse teratocarcinoma. Buc-Caron, M.H., Launay, J.M., Lamblin, D., Kellermann, O. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  10. 8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions of monoamine oxidase inhibition and A2A receptor antagonism. Chen, J.F., Steyn, S., Staal, R., Petzer, J.P., Xu, K., Van Der Schyf, C.J., Castagnoli, K., Sonsalla, P.K., Castagnoli, N., Schwarzschild, M.A. J. Biol. Chem. (2002) [Pubmed]
  11. Transforming growth factor beta2 haploinsufficient mice develop age-related nigrostriatal dopamine deficits. Andrews, Z.B., Zhao, H., Frugier, T., Meguro, R., Grattan, D.R., Koishi, K., McLennan, I.S. Neurobiol. Dis. (2006) [Pubmed]
  12. Regulation of protein kinase C by the anti-Parkinson drug, MAO-B inhibitor, rasagiline and its derivatives, in vivo. Bar-Am, O., Yogev-Falach, M., Amit, T., Sagi, Y., Youdim, M.B. J. Neurochem. (2004) [Pubmed]
  13. Inhibition of MAO B, but not MAO A, blocks DSP-4 toxicity on central NE neurons. Gibson, C.J. Eur. J. Pharmacol. (1987) [Pubmed]
  14. Striatal damage and oxidative stress induced by the mitochondrial toxin malonate are reduced in clorgyline-treated rats and MAO-A deficient mice. Maragos, W.F., Young, K.L., Altman, C.S., Pocernich, C.B., Drake, J., Butterfield, D.A., Seif, I., Holschneider, D.P., Chen, K., Shih, J.C. Neurochem. Res. (2004) [Pubmed]
  15. Prevention of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic toxicity in mice by MDL 72145, a selective inhibitor of MAO-B. Kindt, M.V., Heikkila, R.E. Life Sci. (1986) [Pubmed]
  16. SL25.1131 [3(S),3a(S)-3-methoxymethyl-7-[4,4,4-trifluorobutoxy]-3,3a,4,5-tetrahydro-1,3-oxazolo[3,4-a]quinolin-1-one], a new, reversible, and mixed inhibitor of monoamine oxidase-A and monoamine oxidase-B: biochemical and behavioral profile. Aubin, N., Barneoud, P., Carter, C., Caille, D., Sontag, N., Marc, C., Lolivier, J., Gardes, A., Perron, C., Le Kim, A., Charieras, T., Pandini, M., Burnier, P., Puech, F., Jegham, S., George, P., Scatton, B., Curet, O. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  17. Effect of nonselective and selective inhibitors of monoamine oxidases A and B on pethidine toxicity in mice. Boden, R., Botting, R., Coulson, P., Spanswick, G. Br. J. Pharmacol. (1984) [Pubmed]
  18. Autoradiographic localisation of [3H]2-BFI imidazoline I2 binding sites in mouse brain. MacInnes, N., Handley, S.L. Eur. J. Pharmacol. (2005) [Pubmed]
  19. Potent neuroprotective and antioxidant activity of apomorphine in MPTP and 6-hydroxydopamine induced neurotoxicity. Grünblatt, E., Mandel, S., Gassen, M., Youdim, M.B. J. Neural Transm. Suppl. (1999) [Pubmed]
  20. Different effects of monoamine oxidase inhibition on MPTP depletion of heart and brain catecholamines in mice. Fuller, R.W., Hemrick-Luecke, S.K., Kindt, M.V., Heikkila, R.E. Life Sci. (1988) [Pubmed]
  21. Differential age-related changes of MAO-A and MAO-B in mouse brain and peripheral organs. Saura, J., Richards, J.G., Mahy, N. Neurobiol. Aging (1994) [Pubmed]
  22. Developmental expression of monoamine oxidases A and B in the central and peripheral nervous systems of the mouse. Vitalis, T., Fouquet, C., Alvarez, C., Seif, I., Price, D., Gaspar, P., Cases, O. J. Comp. Neurol. (2002) [Pubmed]
  23. Striatal dopamine metabolism in monoamine oxidase B-deficient mice: a brain dialysis study. Fornai, F., Chen, K., Giorgi, F.S., Gesi, M., Alessandri, M.G., Shih, J.C. J. Neurochem. (1999) [Pubmed]
  24. Age-dependent effects of the 2'-methyl analog of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine: prevention by inhibitors of monoamine oxidase B. Finnegan, K.T., Irwin, I., Delanney, L.E., Langston, J.W. J. Pharmacol. Exp. Ther. (1995) [Pubmed]
  25. Rapid and simultaneous determination of monoamine oxidase A and monoamine oxidase B activities in mouse brain homogenates by liquid chromatography with electrochemical detection. Freeman, K.B., Bulawa, M.C., Zeng, Q., Blank, C.L. Anal. Biochem. (1993) [Pubmed]
  26. The anticonvulsant FCE 26743 is a selective and short-acting MAO-B inhibitor devoid of inducing properties towards cytochrome P450-dependent testosterone hydroxylation in mice and rats. Strolin Benedetti, M.S., Marrari, P., Colombo, M., Castelli, M.G., Arand, M., Oesch, F., Dostert, P. J. Pharm. Pharmacol. (1994) [Pubmed]
  27. Difference in monoamine oxidase B activity between C57 black and albino NMRI mouse strains may explain differential effects of the neurotoxin MPTP. Zimmer, J., Geneser, F.A. Neurosci. Lett. (1987) [Pubmed]
  28. Cholinergic neurons with monoamine oxidase type B (MAOB)-activity in the laterodorsal tegmental nucleus of the mouse. Ikemoto, K., Kitahama, K., Maeda, T., Jouvet, M., Nagatsu, I. Neurosci. Lett. (1999) [Pubmed]
  29. Drug-induced changes in motor activity after selective MAO inhibition. Gianutsos, G., Carlson, G.M., Godfrey, J.G. Pharmacol. Biochem. Behav. (1983) [Pubmed]
  30. Onset and progression of motor deficits in motor neuron degeneration (mnd) mice are unaltered by the glycine/NMDA receptor antagonist L-701,324 or the MAO-B inhibitor R(-)-deprenyl. Boyce, S., Webb, J.K., Carlson, E., Rupniak, N.M., Hill, R.G., Martin, J.E. Exp. Neurol. (1999) [Pubmed]
  31. The circadian rhythm of 5-HT biosynthetic and degradative enzymes in immortalized mouse neuroendocrine pineal cell line--a model for studying circadian rhythm. Yeung Lam, P., Chen, K., Shih, J.C. Life Sci. (2004) [Pubmed]
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