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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Inhibitory effect of coumarins from Weigela subsessilis on low density lipoprotein oxidation.

Oxidation of low density lipoprotein (LDL) is thought to be a major factor in the pathophysiology of atherosclerosis. In the present study, we found that coumarins isolated from Weigela subsessilis (Caprifoliaceae) inhibited LDL oxidation mediated by either catalytic copper ions (Cu2+) or free radicals generated with the azo compound 2,2'-azobis-(2-amidinopropane)dihydrochloride (AAPH). Of the coumarins tested, scopoletin (1) and cleomiscosin A (2) increased the lag time of conjugated diene formation and inhibited the generation of thiobarbituric acid reactive substances (TBARS) in a dose-dependent manner. In addition, it was found that compounds 1 and 2 had the capacity to protect the fragmentation of apolipoprotein B-100 (apoB-100). These results suggest that W. subsessilis and its active coumarins, 1 and 2, may have a role to play in preventing the LDL oxidation involved in atherogenesis.[1]


  1. Inhibitory effect of coumarins from Weigela subsessilis on low density lipoprotein oxidation. Thuong, P.T., Na, M., Su, N.D., Seong, R.S., Lee, Y.M., Sok, D.E., Bae, K. Biol. Pharm. Bull. (2005) [Pubmed]
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