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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Atherosclerosis


Psychiatry related information on Atherosclerosis


High impact information on Atherosclerosis

  • These observations raise the possibility that an impaired ABCA1 pathway contributes to the enhanced atherogenesis associated with common inflammatory and metabolic disorders [9].
  • Cells cultured from human atheroma contained mRNAs for the PDGF A chain (16 of 17 isolates) but none (of 13) that encoded PDGF B chain (the c-sis proto-oncogene product) [10].
  • We also show that nicotine accelerates the growth of tumor and atheroma in association with increased neovascularization [11].
  • We have examined the effect of p53 inactivation on atherogenesis in apoE-knockout mice, an animal model for atherosclerosis [12].
  • Here we determine whether interruption of CD40 signalling influences atherogenesis in vivo in hyperlipidaemic mice [13].

Chemical compound and disease context of Atherosclerosis

  • Macrophage type-I and type-II class-A scavenger receptors (MSR-A) are implicated in the pathological deposition of cholesterol during atherogenesis as a result of receptor-mediated uptake of modified low-density lipoproteins (mLDL) [14].
  • Malondialdehyde-altered protein occurs in atheroma of Watanabe heritable hyperlipidemic rabbits [15].
  • Specific interaction of lysine, arginine-rich segments of the apoB-100 lipoproteins, LDL, IDL and Lp (a), with the negatively charged glycosaminoglycans (GAGs) of PGs cause retention of the lipoproteins, one of the initiation process of atherogenesis [2].
  • Oxidative stress is implicated in atherogenesis, yet most clinical trials with antioxidants, particularly vitamin E, have failed to protect against atherosclerotic diseases [16].
  • This indicates that estrogen attenuates atherogenesis in cholesterol-fed ovariectomized rabbits and that two commonly prescribed progestogens do not counteract the effect [17].

Biological context of Atherosclerosis


Anatomical context of Atherosclerosis


Gene context of Atherosclerosis

  • However, the role of CD40 signalling in atherogenesis in vivo remains unknown [13].
  • To test MCP-1's role in atherogenesis, low density lipoprotein (LDL) receptor-deficient mice were made genetically deficient for MCP-1 and fed a high cholesterol diet [27].
  • In addition, stromelysin-3 mRNA and protein colocalized with CD40L and CD40 within atheroma [28].
  • Indeed, human atheroma in situ expressed IL-18 and elevated levels of its receptor subunits, IL-18Ralpha/beta, compared with nondiseased arterial tissue [29].
  • Apolipoprotein E (apo E)-deficient mice are severely hypercholesterolemic and develop advanced atheromas independent of diet [30].

Analytical, diagnostic and therapeutic context of Atherosclerosis


  1. Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency. Jiang, X.C., Qin, S., Qiao, C., Kawano, K., Lin, M., Skold, A., Xiao, X., Tall, A.R. Nat. Med. (2001) [Pubmed]
  2. The extracellular matrix on atherogenesis and diabetes-associated vascular disease. Camejo, G., Olsson, U., Hurt-Camejo, E., Baharamian, N., Bondjers, G. Atherosclerosis. Supplements. (2002) [Pubmed]
  3. Infectious agents are not necessary for murine atherogenesis. Wright, S.D., Burton, C., Hernandez, M., Hassing, H., Montenegro, J., Mundt, S., Patel, S., Card, D.J., Hermanowski-Vosatka, A., Bergstrom, J.D., Sparrow, C.P., Detmers, P.A., Chao, Y.S. J. Exp. Med. (2000) [Pubmed]
  4. Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities. Grosser, T., Fries, S., FitzGerald, G.A. J. Clin. Invest. (2006) [Pubmed]
  5. Increased plasminogen activator inhibitor type 1 in coronary artery atherectomy specimens from type 2 diabetic compared with nondiabetic patients: a potential factor predisposing to thrombosis and its persistence. Sobel, B.E., Woodcock-Mitchell, J., Schneider, D.J., Holt, R.E., Marutsuka, K., Gold, H. Circulation (1998) [Pubmed]
  6. The association between APOE and dementia does not seem to be mediated by vascular factors. Prince, M., Lovestone, S., Cervilla, J., Joels, S., Powell, J., Russ, C., Mann, A. Neurology (2000) [Pubmed]
  7. Interaction of the N-terminal domain of apolipoprotein E4 with heparin. Dong, J., Peters-Libeu, C.A., Weisgraber, K.H., Segelke, B.W., Rupp, B., Capila, I., Hernáiz, M.J., LeBrun, L.A., Linhardt, R.J. Biochemistry (2001) [Pubmed]
  8. Production, characterization, and interspecies reactivities of monoclonal antibodies against human class A macrophage scavenger receptors. Tomokiyo, R., Jinnouchi, K., Honda, M., Wada, Y., Hanada, N., Hiraoka, T., Suzuki, H., Kodama, T., Takahashi, K., Takeya, M. Atherosclerosis (2002) [Pubmed]
  9. ATP-binding cassette transporter A1: a cell cholesterol exporter that protects against cardiovascular disease. Oram, J.F., Heinecke, J.W. Physiol. Rev. (2005) [Pubmed]
  10. Production of platelet-derived growth factor-like mitogen by smooth-muscle cells from human atheroma. Libby, P., Warner, S.J., Salomon, R.N., Birinyi, L.K. N. Engl. J. Med. (1988) [Pubmed]
  11. Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis. Heeschen, C., Jang, J.J., Weis, M., Pathak, A., Kaji, S., Hu, R.S., Tsao, P.S., Johnson, F.L., Cooke, J.P. Nat. Med. (2001) [Pubmed]
  12. The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo. Guevara, N.V., Kim, H.S., Antonova, E.I., Chan, L. Nat. Med. (1999) [Pubmed]
  13. Reduction of atherosclerosis in mice by inhibition of CD40 signalling. Mach, F., Schönbeck, U., Sukhova, G.K., Atkinson, E., Libby, P. Nature (1998) [Pubmed]
  14. A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Suzuki, H., Kurihara, Y., Takeya, M., Kamada, N., Kataoka, M., Jishage, K., Ueda, O., Sakaguchi, H., Higashi, T., Suzuki, T., Takashima, Y., Kawabe, Y., Cynshi, O., Wada, Y., Honda, M., Kurihara, H., Aburatani, H., Doi, T., Matsumoto, A., Azuma, S., Noda, T., Toyoda, Y., Itakura, H., Yazaki, Y., Kodama, T. Nature (1997) [Pubmed]
  15. Malondialdehyde-altered protein occurs in atheroma of Watanabe heritable hyperlipidemic rabbits. Haberland, M.E., Fong, D., Cheng, L. Science (1988) [Pubmed]
  16. Antioxidants protect from atherosclerosis by a heme oxygenase-1 pathway that is independent of free radical scavenging. Wu, B.J., Kathir, K., Witting, P.K., Beck, K., Choy, K., Li, C., Croft, K.D., Mori, T.A., Tanous, D., Adams, M.R., Lau, A.K., Stocker, R. J. Exp. Med. (2006) [Pubmed]
  17. Estrogen monotherapy and combined estrogen-progestogen replacement therapy attenuate aortic accumulation of cholesterol in ovariectomized cholesterol-fed rabbits. Haarbo, J., Leth-Espensen, P., Stender, S., Christiansen, C. J. Clin. Invest. (1991) [Pubmed]
  18. Crosstalk between LXR and toll-like receptor signaling mediates bacterial and viral antagonism of cholesterol metabolism. Castrillo, A., Joseph, S.B., Vaidya, S.A., Haberland, M., Fogelman, A.M., Cheng, G., Tontonoz, P. Mol. Cell (2003) [Pubmed]
  19. Involvement of 15-lipoxygenase in early stages of atherogenesis. Kühn, H., Belkner, J., Zaiss, S., Fährenklemper, T., Wohlfeil, S. J. Exp. Med. (1994) [Pubmed]
  20. Tumor necrosis factor-mediated release of platelet-derived growth factor from cultured endothelial cells. Hajjar, K.A., Hajjar, D.P., Silverstein, R.L., Nachman, R.L. J. Exp. Med. (1987) [Pubmed]
  21. Enhanced development of atherosclerosis in cholesterol-fed rabbits by suppression of cell-mediated immunity. Roselaar, S.E., Schonfeld, G., Daugherty, A. J. Clin. Invest. (1995) [Pubmed]
  22. Macrophage colony-stimulating factor regulates both activities of neutral and acidic cholesteryl ester hydrolases in human monocyte-derived macrophages. Inaba, T., Shimano, H., Gotoda, T., Harada, K., Shimada, M., Kawamura, M., Yazaki, Y., Yamada, N. J. Clin. Invest. (1993) [Pubmed]
  23. The effects of alpha tocopherol supplementation on monocyte function. Decreased lipid oxidation, interleukin 1 beta secretion, and monocyte adhesion to endothelium. Devaraj, S., Li, D., Jialal, I. J. Clin. Invest. (1996) [Pubmed]
  24. Vascular cell adhesion molecule-1 and smooth muscle cell activation during atherogenesis. Libby, P., Li, H. J. Clin. Invest. (1993) [Pubmed]
  25. Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice. Moore, K.J., Kunjathoor, V.V., Koehn, S.L., Manning, J.J., Tseng, A.A., Silver, J.M., McKee, M., Freeman, M.W. J. Clin. Invest. (2005) [Pubmed]
  26. IFN-gamma potentiates atherosclerosis in ApoE knock-out mice. Gupta, S., Pablo, A.M., Jiang, X., Wang, N., Tall, A.R., Schindler, C. J. Clin. Invest. (1997) [Pubmed]
  27. Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice. Gu, L., Okada, Y., Clinton, S.K., Gerard, C., Sukhova, G.K., Libby, P., Rollins, B.J. Mol. Cell (1998) [Pubmed]
  28. Expression of stromelysin-3 in atherosclerotic lesions: regulation via CD40-CD40 ligand signaling in vitro and in vivo. Schönbeck, U., Mach, F., Sukhova, G.K., Atkinson, E., Levesque, E., Herman, M., Graber, P., Basset, P., Libby, P. J. Exp. Med. (1999) [Pubmed]
  29. Expression of interleukin (IL)-18 and functional IL-18 receptor on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for atherogenesis. Gerdes, N., Sukhova, G.K., Libby, P., Reynolds, R.S., Young, J.L., Schönbeck, U. J. Exp. Med. (2002) [Pubmed]
  30. Apolipoprotein AI transgene corrects apolipoprotein E deficiency-induced atherosclerosis in mice. Pászty, C., Maeda, N., Verstuyft, J., Rubin, E.M. J. Clin. Invest. (1994) [Pubmed]
  31. Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice. van Vlijmen, B.J., van den Maagdenberg, A.M., Gijbels, M.J., van der Boom, H., HogenEsch, H., Frants, R.R., Hofker, M.H., Havekes, L.M. J. Clin. Invest. (1994) [Pubmed]
  32. Activation of monocyte/macrophage functions related to acute atheroma complication by ligation of CD40: induction of collagenase, stromelysin, and tissue factor. Mach, F., Schönbeck, U., Bonnefoy, J.Y., Pober, J.S., Libby, P. Circulation (1997) [Pubmed]
  33. New anti-monocyte chemoattractant protein-1 gene therapy attenuates atherosclerosis in apolipoprotein E-knockout mice. Ni, W., Egashira, K., Kitamoto, S., Kataoka, C., Koyanagi, M., Inoue, S., Imaizumi, K., Akiyama, C., Nishida, K.I., Takeshita, A. Circulation (2001) [Pubmed]
  34. The catalytic domain of endogenous urokinase-type plasminogen activator is required for the mitogenic activity of platelet-derived and basic fibroblast growth factors in human vascular smooth muscle cells. Padró, T., Mesters, R.M., Dankbar, B., Hintelmann, H., Bieker, R., Kiehl, M., Berdel, W.E., Kienast, J. J. Cell. Sci. (2002) [Pubmed]
  35. A randomized trial of aggressive lipid reduction for improvement of myocardial ischemia, symptom status, and vascular function in patients with coronary artery disease not amenable to intervention. Fathi, R., Haluska, B., Short, L., Marwick, T.H. Am. J. Med. (2003) [Pubmed]
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