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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Linezolid for the treatment of a heteroresistant Staphylococcus aureus shunt infection.

The emergence of multidrug-resistant bacteria as the cause of ventriculoperitoneal shunt infections is a disconcerting phenomenon that often requires the use of alternative antimicrobials due to resistance against commonly used agents. The following is a case report describing the successful treatment of a ventriculoperitoneal shunt infection caused by a heteroresistant strain of Staphylococcus aureus with linezolid. Linezolid may have utility in treating pediatric CNS infections due to its tolerability, excellent blood-brain barrier penetration, and activity against multiple resistant Gram-positive organisms such as S. aureus, vancomycin-resistant Enterococcus faecium and Streptococcus pneumoniae.[1]


  1. Linezolid for the treatment of a heteroresistant Staphylococcus aureus shunt infection. Cook, A.M., Ramsey, C.N., Martin, C.A., Pittman, T. Pediatric neurosurgery. (2005) [Pubmed]
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