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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Mapping of MAX to human chromosome 14 and mouse chromosome 12 by in situ hybridization.

The protein encoded by the MAX gene is a member of the class of basic region-helix-loop-helix-zipper proteins and has been demonstrated to associate with N-, L-, and c-Myc proteins both in vitro and in vivo. Heterodimers formed between c-Myc and Max proteins have been shown to possess sequence-specific DNA-binding activity. Here we report the mapping of the MAX gene to a single region on human chromosome 14 (bands q22-q24) and to mouse chromosome 12 (region D). Chromosome abnormalities linked to several neoplasms have been previously associated with this region on human chromosome 14. The mapping results also confirm a region of homology between human chromosome 14q22-24 and mouse chromosome 12 region D.[1]


  1. Mapping of MAX to human chromosome 14 and mouse chromosome 12 by in situ hybridization. Gilladoga, A.D., Edelhoff, S., Blackwood, E.M., Eisenman, R.N., Disteche, C.M. Oncogene (1992) [Pubmed]
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