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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Screening for ZNF230 gene mutation and analysis of its correlation with azoospermia.

OBJECTIVE: To investigate the possible association between ZNF230 gene and azoospermia. METHODS: Screening for mutation of all 6 exons of ZNF230 gene was performed by denaturing high performance liquid chromatography(DHPLC) in 99 patients with azoospermia and in 115 healthy men as controls. RESULTS: An A-->G transition at nucleotide 316 in exon 6 was identified. There were significant differences in the distribution profiles of both allele and genotype frequencies between patient group and control group (P < 0.01 and P < 0.05, respectively). In addition,there was a statistically significant difference in the serum follicle stimulating hormone (FSH) level between the patients with GG/GA genotype and those with AA genotype (P < 0.05). CONCLUSION: ZNF230 gene may be associated with azoospermia, and the A316G mutation may be correlated with the serum FSH level.[1]

References

  1. Screening for ZNF230 gene mutation and analysis of its correlation with azoospermia. Dong, J.T., Zhang, S.Z., Ma, Y.X., Yang, K.X., Huang, M.K., Sun, Y., He, G.P., Li, Y., Zhang, W., Peng, Y. Zhonghua Yi Xue Yi Chuan Xue Za Zhi (2005) [Pubmed]
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