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Disease relevance of Oligospermia


Psychiatry related information on Oligospermia


High impact information on Oligospermia

  • BACKGROUND: Some infertile men with azoospermia or severe oligospermia have small deletions in regions of the Y chromosome [7].
  • Loss of boule function results in azoospermia; meiotic divisions are blocked, although limited spermatid differentiation occurs [8].
  • A candidate gene for the Y-chromosome azoospermia factor (AZF) has been identified and named Deleted in Azoospermia (DAZ) [8].
  • Such agents can affect fertility and other aspects of male reproductive function, for example, treatment with anti-cancer drugs such as cyclophosphamide has been associated with oligozoospermia, azoospermia and increased levels of serum follicle-stimulating hormone (FSH) [9].
  • Such deletions determine azoospermia more frequently than severe oligozoospermia and involve especially the AZFc region including the DAZ gene family [10].

Chemical compound and disease context of Oligospermia


Biological context of Oligospermia

  • Three different spermatogenesis loci have been mapped on the Y chromosome and named "azoospermia factors" (AZFa, b, and c) [10].
  • The Drosophila boule gene is expressed exclusively in the male germline and encodes an RNA binding protein closely related to the mammalian fertility factors encoded by the DAZ (Deleted in Azoospermia) and DAZL (DAZ-like) genes [16].
  • These results suggested that neither genetic polymorphisms in the AR gene (CAG and GGC repeats) nor that in hepatic androgen metabolism (CYP3A4 A/G variant) were the major contributors to the within-population variations in susceptibility to T-induced azoospermia [17].
  • A phenotypically normal male with azoospermia was found to have a translocation between the short arm of the Y chromosome and the distal long arm of a chromosome 4 [18].
  • Progressive dose-dependent testicular atrophy and oligospermia occurred at low and intermediate dosages of doxorubicin (0.1 to 5 mg./kg.). Marked testicular atrophy, oligospermia and germinal aplasia were observed at high dosage of doxorubicin (10 mg./kg.). LD50 for animal mortality at day 56 +/- 2 for doxorubicin appears to be 10 mg./kg [19].

Anatomical context of Oligospermia


Gene context of Oligospermia

  • We investigated the function of DDX3Y, the Y chromosome AZFa region encoding a putative DEAD-box RNA helicase protein, the loss of which results in oligozoospermia or azoospermia in humans [25].
  • Y-chromosomal DAZ (deleted in azoospermia) and autosomal DAZ-like (DAZL) comprise a gene family involved in gametogenesis [26].
  • HLA-DR antigen and HLA-DRB1 genotyping with nonobstructive azoospermia in Japan [27].
  • RESULT(s): All 12 biopsy specimens from patients with obstructive azoospermia were positive for telomerase activity, hTR, and hTERT [28].
  • The concentration of S-Tf-R in post-vasectomy samples was lower than that in patients with azoospermia of primary testicular origin (P < 0.05; positive likelihood ration = 7 at value of 8.3 IU/ ml) [29].

Analytical, diagnostic and therapeutic context of Oligospermia


  1. Androgen insensitivity as a cause of infertility in otherwise normal men. Aiman, J., Griffin, J.E., Gazak, J.M., Wilson, J.D., MacDonald, P.C. N. Engl. J. Med. (1979) [Pubmed]
  2. Proportion of cystic fibrosis gene mutations not detected by routine testing in men with obstructive azoospermia. Mak, V., Zielenski, J., Tsui, L.C., Durie, P., Zini, A., Martin, S., Longley, T.B., Jarvi, K.A. JAMA (1999) [Pubmed]
  3. Male infertility, impaired spermatogenesis, and azoospermia in mice deficient for the pseudophosphatase Sbf1. Firestein, R., Nagy, P.L., Daly, M., Huie, P., Conti, M., Cleary, M.L. J. Clin. Invest. (2002) [Pubmed]
  4. Bromocriptine and endocrine disorders. Spark, R.F., Dickstein, G. Ann. Intern. Med. (1979) [Pubmed]
  5. Incidence of sulphasalazine-induced male infertility. Birnie, G.G., McLeod, T.I., Watkinson, G. Gut (1981) [Pubmed]
  6. Anthropomorphic, hormonal, and psychologic correlates of semen quality in endurance-trained male athletes. Ayers, J.W., Komesu, Y., Romani, T., Ansbacher, R. Fertil. Steril. (1985) [Pubmed]
  7. Microdeletions in the Y chromosome of infertile men. Pryor, J.L., Kent-First, M., Muallem, A., Van Bergen, A.H., Nolten, W.E., Meisner, L., Roberts, K.P. N. Engl. J. Med. (1997) [Pubmed]
  8. Meiotic cell cycle requirement for a fly homologue of human Deleted in Azoospermia. Eberhart, C.G., Maines, J.Z., Wasserman, S.A. Nature (1996) [Pubmed]
  9. Paternal cyclophosphamide treatment of rats causes fetal loss and malformations without affecting male fertility. Trasler, J.M., Hales, B.F., Robaire, B. Nature (1985) [Pubmed]
  10. Y chromosome microdeletions and alterations of spermatogenesis. Foresta, C., Moro, E., Ferlin, A. Endocr. Rev. (2001) [Pubmed]
  11. Reversible azoospermia induced by the anabolic steroid 19-nortestosterone. Schürmeyer, T., Knuth, U.A., Belkien, L., Nieschlag, E. Lancet (1984) [Pubmed]
  12. Infertility in male pesticide workers. Whorton, D., Krauss, R.M., Marshall, S., Milby, T.H. Lancet (1977) [Pubmed]
  13. Azoospermia induced by 19-nortestosterone. Parrott, R.F. Lancet (1984) [Pubmed]
  14. Obstructive azoospermia as a diagnostic criterion for the cystic fibrosis syndrome. Stern, R.C., Boat, T.F., Doershuk, C.F. Lancet (1982) [Pubmed]
  15. The low gonadotropin-independent constitutive production of testicular testosterone is sufficient to maintain spermatogenesis. Zhang, F.P., Pakarainen, T., Poutanen, M., Toppari, J., Huhtaniemi, I. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  16. Biphasic subcellular localization of the DAZL-related protein boule in Drosophila spermatogenesis. Cheng, M.H., Maines, J.Z., Wasserman, S.A. Dev. Biol. (1998) [Pubmed]
  17. Pharmacogenetic polymorphisms of the AR and metabolism and susceptibility to hormone-induced azoospermia. Yu, B., Handelsman, D.J. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  18. Characterization of a (Y;4) translocation by DNA hybridization. Andersson, M., Page, D.C., Brown, L.G., Elfving, K., de la Chapelle, A. Hum. Genet. (1988) [Pubmed]
  19. Testicular cytotoxicity of intravenous doxorubicin in rats. Lui, R.C., Laregina, M.C., Herbold, D.R., Johnson, F.E. J. Urol. (1986) [Pubmed]
  20. Human seminal clusterin (SP-40,40). Isolation and characterization. O'Bryan, M.K., Baker, H.W., Saunders, J.R., Kirszbaum, L., Walker, I.D., Hudson, P., Liu, D.Y., Glew, M.D., d'Apice, A.J., Murphy, B.F. J. Clin. Invest. (1990) [Pubmed]
  21. Disruption of Mtmr2 produces CMT4B1-like neuropathy with myelin outfolding and impaired spermatogenesis. Bolino, A., Bolis, A., Previtali, S.C., Dina, G., Bussini, S., Dati, G., Amadio, S., Del Carro, U., Mruk, D.D., Feltri, M.L., Cheng, C.Y., Quattrini, A., Wrabetz, L. J. Cell Biol. (2004) [Pubmed]
  22. A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans. Xu, E.Y., Moore, F.L., Pera, R.A. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  23. The human autosomal gene DAZLA: testis specificity and a candidate for male infertility. Yen, P.H., Chai, N.N., Salido, E.C. Hum. Mol. Genet. (1996) [Pubmed]
  24. The frequency of androgen receptor deficiency in infertile men. Aiman, J., Griffin, J.E. J. Clin. Endocrinol. Metab. (1982) [Pubmed]
  25. Human DDX3Y, the Y-encoded isoform of RNA helicase DDX3, rescues a hamster temperature-sensitive ET24 mutant cell line with a DDX3X mutation. Sekiguchi, T., Iida, H., Fukumura, J., Nishimoto, T. Exp. Cell Res. (2004) [Pubmed]
  26. Partial rescue of the Dazl knockout mouse by the human DAZL gene. Vogel, T., Speed, R.M., Ross, A., Cooke, H.J. Mol. Hum. Reprod. (2002) [Pubmed]
  27. HLA-DR antigen and HLA-DRB1 genotyping with nonobstructive azoospermia in Japan. Tsujimura, A., Takahara, S., Kitamura, M., Miura, H., Koga, M., Sada, M., Tsuji, T., Matsumiya, K., Okuyama, A. J. Androl. (1999) [Pubmed]
  28. Telomerase activity and expression of telomerase subunits in the testicular tissue of infertile patients. Schrader, M., Müller, M., Heicappell, R., Krause, H., Schulze, W., Miller, K. Fertil. Steril. (2000) [Pubmed]
  29. The possible meaning of transferrin and its soluble receptors in seminal plasma as markers of the seminiferous epithelium. Zalata, A., Hafez, T., Schoonjans, F., Comhaire, F. Hum. Reprod. (1996) [Pubmed]
  30. Graded testosterone infusions distinguish gonadotropin negative-feedback responsiveness in Asian and white men--a Clinical Research Center study. Wang, C., Berman, N.G., Veldhuis, J.D., Der, T., McDonald, V., Steiner, B., Swerdloff, R.S. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  31. Molecular detection of a translocation (Y;11) (q11.2;q24) in a 45,X male with signs of Jacobsen syndrome. Van Hemel, J.O., Eussen, B., Wesby-van Swaay, E., Oostra, B.A. Hum. Genet. (1992) [Pubmed]
  32. Use of electively cryopreserved microsurgically aspirated epididymal sperm with IVF and intracytoplasmic sperm injection for obstructive azoospermia. Janzen, N., Goldstein, M., Schlegel, P.N., Palermo, G.D., Rosenwaks, Z., Hariprashad, J. Fertil. Steril. (2000) [Pubmed]
  33. Increased sperm count in 25 cases of idiopathic normogonadotropic oligospermia following treatment with tamoxifen. Buvat, J., Ardaens, K., Lemaire, A., Gauthier, A., Gasnault, J.P., Buvat-Herbaut, M. Fertil. Steril. (1983) [Pubmed]
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