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Ukai, S. et al.

Ukai, Kawaguchi, Ishii, Yamamoto, Ogawa, Mizuno-Matsumoto, Robinson, Fujita, Yoshimine, Shinosaki, Takeda,

SAM(g2) analysis for detecting spike localization: a comparison with clinical symptoms and ECD analysis in an epileptic patient.

SAM(g2) analysis, a combination of synthetic aperture magnetometry (SAM) and excess kurtosis (g2) method, is a novel epilepsy analysis procedure based on a spatial filtering technique. By producing a three-dimensional image of the g2 values and superimposing them onto a patient's MR images, this analysis can automatically estimate spike localization from raw MEG epilepsy signals including spikes. The aim of this study is to examine SAM(g2) analysis using MEG signals of an epileptic patient, whose clinical symptoms of colored elementary visual auras had ceased in accordance with the changes of the estimated localizations of the equivalent current dipoles (ECDs) of the interictal spikes. His visual auras were experienced in 1997, while they ceased in 1999 with effective medication. The patient provided written informed consent for the experimental procedures. The MEG signals were recorded in 1997 and 1999, and were analyzed using both ECD and SAM(g2) analyses. For the MEG signals of 1997, ECD analysis estimated most of the interictal spikes in the right fusiform and inferior temporal gyri, which subserve human color processing. SAM(g2) analysis also estimated them in the same areas. For those of 1999, both ECD and SAM(g2) analyses estimated them in the right transverse gyrus of Heschl. As well as ECD analysis, SAM(g2) analysis successfully estimated the changes of the localizations of the interictal spikes in accordance with the changes of the patient's clinical symptoms, indicating that SAM(g2) analysis is useful for detection of interictal spike localization in epileptic patients.[1]

References

SAM(g2) analysis for detecting spike localization: a comparison with clinical symptoms and ECD analysis in an epileptic patient. Ukai, S., Kawaguchi, S., Ishii, R., Yamamoto, M., Ogawa, A., Mizuno-Matsumoto, Y., Robinson, S.E., Fujita, N., Yoshimine, T., Shinosaki, K., Takeda, M. Neurology & clinical neurophysiology [electronic resource] : NCN. (2004) [Pubmed]

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