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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Delayed clearance of fetal lung liquid and sodium transport--genetic predisposition not evident yet.

The epithelial Na+ channel (ENaC) contributes to the clearance of fetal lung liquid. In premature infants, low ENaC activity and low expression level of alpha-ENaC have been associated with respiratory failure. The polymorphism in the alpha-ENaC gene remains to be studied as a factor explaining the variation in the incidence of transient tachypnoea or respiratory distress syndrome in the newborn. Conclusion: The study of genetic predisposition to common multifactorial diseases requires analyses of large, well-defined cohorts for representative variants of relevant candidate genes.[1]


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