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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Synthesis and assay of isoquinoline derivatives as HIV-1 Tat-TAR interaction inhibitors.

Four new isoquinoline derivatives bearing guanidinium group or amino group-terminated side chain were synthesized to target the HIV-1 TAR element. Their abilities to bind TAR RNA and inhibit Tat-TAR RNA interaction were determined by CE analysis, a Tat-dependent HIV-1 LTR-driven CAT assay and SIV-induced syncytium evaluation.[1]

References

  1. Synthesis and assay of isoquinoline derivatives as HIV-1 Tat-TAR interaction inhibitors. He, M., Yuan, D., Lin, W., Pang, R., Yu, X., Yang, M. Bioorg. Med. Chem. Lett. (2005) [Pubmed]
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