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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Giant Cells

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Disease relevance of Giant Cells


High impact information on Giant Cells


Chemical compound and disease context of Giant Cells


Biological context of Giant Cells


Anatomical context of Giant Cells


Associations of Giant Cells with chemical compounds

  • We therefore investigated the effects of castanospermine, 1-deoxynojirimycin (dNM) and 1-deoxymannojirimycin (dMM), three trimming glycosidase inhibitors which perturb N-linked glycan structure, on induction of the formation of syncytium between HIV-infected and CD4-expressing cells [25].
  • The glucosidase inhibitors castanospermine and dNM, but not the mannosidase inhibitor dMM, inhibited syncytium formation and interfered with infectivity [25].
  • Mutations that increased the overall hydrophobicity of the gp32 NH2-terminus increased the ability of the viral envelope to induce syncytia formation, whereas introduction of polar or charged amino acids in the same region abolished the fusogenic function of the viral envelope [26].
  • Hodgkin's disease-derived giant cell lines (HD-cells) express high levels of ectosialyltransferase activity presumed to be a galactose-specific lectin recognizing the desialylated 3-fucosyl-N-acetyllactosamine structure (X-hapten) [27].
  • We propose that the V84L mutation reduces metabolic coupling mediated by Ins(1,4,5)P(3) to an extent sufficient to impair the propagation of Ca(2+) waves and the formation of a functional syncytium [28].

Gene context of Giant Cells


Analytical, diagnostic and therapeutic context of Giant Cells


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  15. Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine. Walker, B.D., Kowalski, M., Goh, W.C., Kozarsky, K., Krieger, M., Rosen, C., Rohrschneider, L., Haseltine, W.A., Sodroski, J. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  16. Apoptosis control in syncytia induced by the HIV type 1-envelope glycoprotein complex: role of mitochondria and caspases. Ferri, K.F., Jacotot, E., Blanco, J., Esté, J.A., Zamzami, N., Susin, S.A., Xie, Z., Brothers, G., Reed, J.C., Penninger, J.M., Kroemer, G. J. Exp. Med. (2000) [Pubmed]
  17. A matrix-less measles virus is infectious and elicits extensive cell fusion: consequences for propagation in the brain. Cathomen, T., Mrkic, B., Spehner, D., Drillien, R., Naef, R., Pavlovic, J., Aguzzi, A., Billeter, M.A., Cattaneo, R. EMBO J. (1998) [Pubmed]
  18. Rybp/DEDAF is required for early postimplantation and for central nervous system development. Pirity, M.K., Locker, J., Schreiber-Agus, N. Mol. Cell. Biol. (2005) [Pubmed]
  19. Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor beta/delta. Nadra, K., Anghel, S.I., Joye, E., Tan, N.S., Basu-Modak, S., Trono, D., Wahli, W., Desvergne, B. Mol. Cell. Biol. (2006) [Pubmed]
  20. Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis. Mi, S., Lee, X., Li, X., Veldman, G.M., Finnerty, H., Racie, L., LaVallie, E., Tang, X.Y., Edouard, P., Howes, S., Keith, J.C., McCoy, J.M. Nature (2000) [Pubmed]
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  22. Interneuron Diversity series: Rhythm and mood in perisomatic inhibition. Freund, T.F. Trends Neurosci. (2003) [Pubmed]
  23. Functional profile of tissue-infiltrating and circulating CD68+ cells in giant cell arteritis. Evidence for two components of the disease. Wagner, A.D., Goronzy, J.J., Weyand, C.M. J. Clin. Invest. (1994) [Pubmed]
  24. The purinergic P2Z receptor of human macrophage cells. Characterization and possible physiological role. Falzoni, S., Munerati, M., Ferrari, D., Spisani, S., Moretti, S., Di Virgilio, F. J. Clin. Invest. (1995) [Pubmed]
  25. Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase. Gruters, R.A., Neefjes, J.J., Tersmette, M., de Goede, R.E., Tulp, A., Huisman, H.G., Miedema, F., Ploegh, H.L. Nature (1987) [Pubmed]
  26. Identification of the fusion peptide of primate immunodeficiency viruses. Bosch, M.L., Earl, P.L., Fargnoli, K., Picciafuoco, S., Giombini, F., Wong-Staal, F., Franchini, G. Science (1989) [Pubmed]
  27. Unique antigen of cultured Hodgkin's cells. A putative sialyltransferase. Paietta, E., Stockert, R.J., Morell, A.G., Diehl, V., Wiernik, P.H. J. Clin. Invest. (1986) [Pubmed]
  28. Impaired permeability to Ins(1,4,5)P3 in a mutant connexin underlies recessive hereditary deafness. Beltramello, M., Piazza, V., Bukauskas, F.F., Pozzan, T., Mammano, F. Nat. Cell Biol. (2005) [Pubmed]
  29. The human CD46 molecule is a receptor for measles virus (Edmonston strain). Dörig, R.E., Marcil, A., Chopra, A., Richardson, C.D. Cell (1993) [Pubmed]
  30. Requirement of the mouse I-mfa gene for placental development and skeletal patterning. Kraut, N., Snider, L., Chen, C.M., Tapscott, S.J., Groudine, M. EMBO J. (1998) [Pubmed]
  31. SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation. Takahashi, Y., Carpino, N., Cross, J.C., Torres, M., Parganas, E., Ihle, J.N. EMBO J. (2003) [Pubmed]
  32. Role of transmembrane 4 superfamily (TM4SF) proteins CD9 and CD81 in muscle cell fusion and myotube maintenance. Tachibana, I., Hemler, M.E. J. Cell Biol. (1999) [Pubmed]
  33. Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope. Castedo, M., Roumier, T., Blanco, J., Ferri, K.F., Barretina, J., Tintignac, L.A., Andreau, K., Perfettini, J.L., Amendola, A., Nardacci, R., Leduc, P., Ingber, D.E., Druillennec, S., Roques, B., Leibovitch, S.A., Vilella-Bach, M., Chen, J., Este, J.A., Modjtahedi, N., Piacentini, M., Kroemer, G. EMBO J. (2002) [Pubmed]
  34. Formation of multinucleated giant cells from human monocyte precursors. Mediation by a soluble protein from antigen-and mitogen-stimulated lymphocytes. Postlethwaite, A.E., Jackson, B.K., Beachey, E.H., Kang, A.H. J. Exp. Med. (1982) [Pubmed]
  35. HIV-1 suppression during acute scrub-typhus infection. Watt, G., Kantipong, P., de Souza, M., Chanbancherd, P., Jongsakul, K., Ruangweerayud, R., Loomis-Price, L.D., Polonis, V., Myint, K.S., Birx, D.L., Brown, A.E., Krishna, S. Lancet (2000) [Pubmed]
  36. Detection of mRNAs for urokinase-type plasminogen activator, its receptor, and type 1 inhibitor in giant cell tumors of bone with in situ hybridization. Zheng, M.H., Fan, Y., Panicker, A., Smith, A., Robertson, T., Wysocki, S., Robbins, P., Papadimitriou, J.M., Wood, D.J. Am. J. Pathol. (1995) [Pubmed]
  37. Matrix metalloproteinase 9 (gelatinase B) is expressed in multinucleated giant cells of human giant cell tumor of bone and is associated with vascular invasion. Ueda, Y., Imai, K., Tsuchiya, H., Fujimoto, N., Nakanishi, I., Katsuda, S., Seiki, M., Okada, Y. Am. J. Pathol. (1996) [Pubmed]
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