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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The endocannabinoid system: a drug discovery perspective.

The endocannabinoids are lipid messengers that engage the same cell surface receptors targeted by delta9-tetrahydrocannabinol, the active component of marijuana. They are produced by cells in the brain and other tissues and combine with two subtypes of G protein-coupled cannabinoid receptors, CB1 and CB2. Their ability to modulate a variety of pathophysiological processes, including appetite, pain and mood, provides unique opportunities for drug discovery. Three such opportunities are discussed here: reduction of body weight through blockade of CB1 receptors, alleviation of pain through activation of extracerebral cannabinoid receptors, and modulation of pain and anxiety through inhibition of endocannabinoid degradation.[1]

References

  1. The endocannabinoid system: a drug discovery perspective. Piomelli, D. Current opinion in investigational drugs (London, England : 2000) (2005) [Pubmed]
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