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Antiangiogenic activity of nasunin, an antioxidant anthocyanin, in eggplant peels.

Nasunin, delphinidin-3-(p-coumaroylrutinoside)-5-glucoside, an antioxidant anthocyanin isolated from eggplant peels, was demonstrated as an angiogenesis inhibitor. Nasunin at higher 10 microM suppressed microvessel outgrowth in an ex vivo angiogenesis assay using a rat aortic ring. The effect of nasunin was examined in various in vitro angiogenesis models using human umbilical vein endothelial cells (HUVECs). Nasunin suppressed HUVEC proliferation in a dose-dependent manner (50-200 microM); however, it had no significant effect on HUVEC chemotaxis in a Boyden chamber assay and HUVEC tube formation on a reconstituted basement membrane. These results imply that nasunin with both antioxidant and antiangiogenic activities might be useful to prevent angiogenesis-related diseases.[1]

References

  1. Antiangiogenic activity of nasunin, an antioxidant anthocyanin, in eggplant peels. Matsubara, K., Kaneyuki, T., Miyake, T., Mori, M. J. Agric. Food Chem. (2005) [Pubmed]
 
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