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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Basement Membrane

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Disease relevance of Basement Membrane


Psychiatry related information on Basement Membrane


High impact information on Basement Membrane


Chemical compound and disease context of Basement Membrane


Biological context of Basement Membrane


Anatomical context of Basement Membrane


Associations of Basement Membrane with chemical compounds

  • We examined the expression of laminin, a basement membrane glycoprotein, during this conversion [25].
  • Both integrin complexes are receptors for laminins, major components of basement membranes [26].
  • Both collagens resemble previously characterized type IV basement-membrane collagens with respect to their amino acid composition, cyanogen bromide peptides, chain size, immunological reactivity and tissue localization [27].
  • In the patients receiving placebo the mean width of the muscle capillary basement membrane increased from 135.9 +/- 9.0 nm (S.E.M.) to 169.3 +/- 9.5 nm (P = 0.01), but in those receiving glipizide the value decreased to a level no different from that in subjects without diabetes: from 152.9 +/- 2.9 to 127.5 +/- 5.1 nm (P = 0.01) [28].
  • We report here that in F9 12-1 cells exposed to retinoic acid, synthesis of the SV40 A gene product(s), T and tumour-associated specific antigens (TASA), parallels the appearance of the normal hallmarks of differentiation in this cell line, H-2 antigens and the basement membrane protein laminin [29].

Gene context of Basement Membrane


Analytical, diagnostic and therapeutic context of Basement Membrane


  1. Role of laminin in the attachment of PAM 212 (epithelial) cells to basement membrane collagen. Terranova, V.P., Rohrbach, D.H., Martin, G.R. Cell (1980) [Pubmed]
  2. Perlecan, the major proteoglycan of basement membranes, is altered in patients with Schwartz-Jampel syndrome (chondrodystrophic myotonia). Nicole, S., Davoine, C.S., Topaloglu, H., Cattolico, L., Barral, D., Beighton, P., Hamida, C.B., Hammouda, H., Cruaud, C., White, P.S., Samson, D., Urtizberea, J.A., Lehmann-Horn, F., Weissenbach, J., Hentati, F., Fontaine, B. Nat. Genet. (2000) [Pubmed]
  3. The pathogenic role of macrophage migration inhibitory factor in immunologically induced kidney disease in the rat. Lan, H.Y., Bacher, M., Yang, N., Mu, W., Nikolic-Paterson, D.J., Metz, C., Meinhardt, A., Bucala, R., Atkins, R.C. J. Exp. Med. (1997) [Pubmed]
  4. Immune complex orchitis in vasectomized rabbits. Bigazzi, P.E., Kosuda, L.L., Hsu, K.C., Andres, G.A. J. Exp. Med. (1976) [Pubmed]
  5. Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis. Agrawal, S., Anderson, P., Durbeej, M., van Rooijen, N., Ivars, F., Opdenakker, G., Sorokin, L.M. J. Exp. Med. (2006) [Pubmed]
  6. Skin involvement in amyotrophic lateral sclerosis. Kolde, G., Bachus, R., Ludolph, A.C. Lancet (1996) [Pubmed]
  7. Thin and strong! The bioengineering dilemma in the structural and functional design of the blood-gas barrier. Maina, J.N., West, J.B. Physiol. Rev. (2005) [Pubmed]
  8. Expression and function of laminins in the embryonic and mature vasculature. Hallmann, R., Horn, N., Selg, M., Wendler, O., Pausch, F., Sorokin, L.M. Physiol. Rev. (2005) [Pubmed]
  9. FOS-1 promotes basement-membrane removal during anchor-cell invasion in C. elegans. Sherwood, D.R., Butler, J.A., Kramer, J.M., Sternberg, P.W. Cell (2005) [Pubmed]
  10. Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori. Fujikawa, A., Shirasaka, D., Yamamoto, S., Ota, H., Yahiro, K., Fukada, M., Shintani, T., Wada, A., Aoyama, N., Hirayama, T., Fukamachi, H., Noda, M. Nat. Genet. (2003) [Pubmed]
  11. Increased expression of basement membrane collagen in human diabetic retinopathy. Roy, S., Maiello, M., Lorenzi, M. J. Clin. Invest. (1994) [Pubmed]
  12. Glomerular prostaglandin and thromboxane synthesis in rat nephrotoxic serum nephritis. Effects on renal hemodynamics. Lianos, E.A., Andres, G.A., Dunn, M.J. J. Clin. Invest. (1983) [Pubmed]
  13. Relation of renal growth to diabetic glomerulosclerosis. Levin, N.W., Silveira, E., Cortes, P., Rubenstein, A.H. Lancet (1975) [Pubmed]
  14. Reversal of diabetic nephropathy in human cadaveric kidneys after transplantation into non-diabetic recipients. Abouna, G.M., Al-Adnani, M.S., Kremer, G.D., Kumar, S.A., Daddah, S.K., Kusma, G. Lancet (1983) [Pubmed]
  15. Glomerular basement membrane proteoglycans are derived from a large precursor. Klein, D.J., Brown, D.M., Oegema, T.R., Brenchley, P.E., Anderson, J.C., Dickinson, M.A., Horigan, E.A., Hassell, J.R. J. Cell Biol. (1988) [Pubmed]
  16. Drosophila substrate adhesion molecule: sequence of laminin B1 chain reveals domains of homology with mouse. Montell, D.J., Goodman, C.S. Cell (1988) [Pubmed]
  17. Absence of integrin alpha 7 causes a novel form of muscular dystrophy. Mayer, U., Saher, G., Fässler, R., Bornemann, A., Echtermeyer, F., von der Mark, H., Miosge, N., Pöschl, E., von der Mark, K. Nat. Genet. (1997) [Pubmed]
  18. The Drosophila PS2 antigen is an invertebrate integrin that, like the fibronectin receptor, becomes localized to muscle attachments. Bogaert, T., Brown, N., Wilcox, M. Cell (1987) [Pubmed]
  19. Fibulins: a versatile family of extracellular matrix proteins. Timpl, R., Sasaki, T., Kostka, G., Chu, M.L. Nat. Rev. Mol. Cell Biol. (2003) [Pubmed]
  20. Targeted disruption of the even-skipped gene, evx1, causes early postimplantation lethality of the mouse conceptus. Spyropoulos, D.D., Capecchi, M.R. Genes Dev. (1994) [Pubmed]
  21. Properties of a basement membrane-related glycoprotein synthesized in culture by a mouse embryonal carcinoma-derived cell line. Chung, A.E., Jaffe, R., Freeman, I.L., Vergnes, J.P., Braginski, J.E., Carlin, B. Cell (1979) [Pubmed]
  22. Defective neuromuscular synaptogenesis in agrin-deficient mutant mice. Gautam, M., Noakes, P.G., Moscoso, L., Rupp, F., Scheller, R.H., Merlie, J.P., Sanes, J.R. Cell (1996) [Pubmed]
  23. The effect of diabetic control on the width of skeletal-muscle capillary basement membrane in patients with Type I diabetes mellitus. Raskin, P., Pietri, A.O., Unger, R., Shannon, W.A. N. Engl. J. Med. (1983) [Pubmed]
  24. Interstitial nephritis with anti-tubular-basement-membrane antibody. Bergstein, J., Litman, N. N. Engl. J. Med. (1975) [Pubmed]
  25. Role of laminin A chain in the development of epithelial cell polarity. Klein, G., Langegger, M., Timpl, R., Ekblom, P. Cell (1988) [Pubmed]
  26. Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice. Georges-Labouesse, E., Messaddeq, N., Yehia, G., Cadalbert, L., Dierich, A., Le Meur, M. Nat. Genet. (1996) [Pubmed]
  27. Nonhelical, fibronectin-binding basement-membrane collagen from endodermal cell culture. Engvall, E., Bell, M.L., Carlsson, R.N., Miller, E.J., Ruoslahti, E. Cell (1982) [Pubmed]
  28. Drug-induced reversal of early diabetic microangiopathy. Camerini-Davalos, R.A., Velasco, C., Glasser, M., Bloodworth, J.M. N. Engl. J. Med. (1983) [Pubmed]
  29. Expression of H-2, laminin and SV40 T and TASA on differentiation of transformed murine teratocarcinoma cells. Knowles, B.B., Pan, S., Solter, D., Linnenbach, A., Croce, C., Huebner, K. Nature (1980) [Pubmed]
  30. Chimaeric mice deficient in dystroglycans develop muscular dystrophy and have disrupted myoneural synapses. Côté, P.D., Moukhles, H., Lindenbaum, M., Carbonetto, S. Nat. Genet. (1999) [Pubmed]
  31. Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis. Aviezer, D., Hecht, D., Safran, M., Eisinger, M., David, G., Yayon, A. Cell (1994) [Pubmed]
  32. Mutation of a gene encoding a protein with extracellular matrix motifs in Usher syndrome type IIa. Eudy, J.D., Weston, M.D., Yao, S., Hoover, D.M., Rehm, H.L., Ma-Edmonds, M., Yan, D., Ahmad, I., Cheng, J.J., Ayuso, C., Cremers, C., Davenport, S., Moller, C., Talmadge, C.B., Beisel, K.W., Tamayo, M., Morton, C.C., Swaroop, A., Kimberling, W.J., Sumegi, J. Science (1998) [Pubmed]
  33. Products of the unc-52 gene in Caenorhabditis elegans are homologous to the core protein of the mammalian basement membrane heparan sulfate proteoglycan. Rogalski, T.M., Williams, B.D., Mullen, G.P., Moerman, D.G. Genes Dev. (1993) [Pubmed]
  34. Basement membrane and repair of injury to peripheral nerve: defining a potential role for macrophages, matrix metalloproteinases, and tissue inhibitor of metalloproteinases-1. La Fleur, M., Underwood, J.L., Rappolee, D.A., Werb, Z. J. Exp. Med. (1996) [Pubmed]
  35. Identification of the cutaneous basement membrane zone antigen and isolation of antibody in linear immunoglobulin A bullous dermatosis. Zone, J.J., Taylor, T.B., Kadunce, D.P., Meyer, L.J. J. Clin. Invest. (1990) [Pubmed]
  36. Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics. Flood-Page, P., Menzies-Gow, A., Phipps, S., Ying, S., Wangoo, A., Ludwig, M.S., Barnes, N., Robinson, D., Kay, A.B. J. Clin. Invest. (2003) [Pubmed]
  37. Identification of haptoglobin as an angiogenic factor in sera from patients with systemic vasculitis. Cid, M.C., Grant, D.S., Hoffman, G.S., Auerbach, R., Fauci, A.S., Kleinman, H.K. J. Clin. Invest. (1993) [Pubmed]
  38. Ontogenesis of glomerular basement membrane: structural and functional properties. Desjardins, M., Bendayan, M. J. Cell Biol. (1991) [Pubmed]
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