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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Skin permeation and stability studies of 5-aminolevulinic acid in a new gel and patch preparation.

A new cubic gel as well as a patch system containing additional carrageenan as matrix were used as vehicles for 5-aminolevulinic acid (5-ALA). Standard diffusion experiments of 5-ALA using Franz-type diffusion cells and porcine skin were performed. Drug stability was monitored by analysing the 5-ALA content in the formulations. The analysis of 5-ALA as non-fluorescent probe was performed after chemical reaction leading to a fluorescent derivative. The 5-ALA permeation through porcine skin after 48 h was the highest from the patch formulation with 80.3% and the second highest from the cubic gel with 66.4%, however only about 40% of 5-ALA were chemical stable after 14 days storage in the patch formulation, whereas no degradation of 5-ALA was measured in the cubic gel over 90 days of observation.[1]


  1. Skin permeation and stability studies of 5-aminolevulinic acid in a new gel and patch preparation. Valenta, C., Auner, B.G., Loibl, I. Journal of controlled release : official journal of the Controlled Release Society. (2005) [Pubmed]
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