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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Drug Stability

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Disease relevance of Drug Stability


High impact information on Drug Stability

  • Our studies indicate that specific modifications at the 7- and 9-positions of the quinoline nucleus, such as those contained in CPT-11, topotecan, and SN-38, enhance drug stability in the presence of HSA [3].
  • The admixture of bisantrene into various lipophilic solvents did not reduce drug precipitation in vivo in the mouse or in vitro in human plasma at 37 degrees C. Drug stability studies using high performance liquid chromatography (HPLC) showed markedly reduced bisantrene stability at alkaline pH [4].
  • Prolonging the infusion of meropenem over 3 hours increases the percentage of the dosing interval that drug concentrations remain above the minimum inhibitory concentration (MIC), thereby maximizing the pharmacodynamics of this agent and adhering to drug stability constraints [5].
  • The degradation mechanism(s) of DDC and DDI was (were) studied by analyzing HPLC chromatograms and by evaluating the drug stability in the extract which was filtered to remove any microbes [6].
  • The degradation of batanopride hydrochloride, an investigational antiemetic drug, was studied in aqueous buffer solutions (pH 2-10; ionic strength, 0.5; 56 degrees C) in an attempt to improve drug stability for parenteral administration [7].

Biological context of Drug Stability


Anatomical context of Drug Stability

  • Stress degradation studies were carried out on guggulsterone (the hypolipidemic agent in the gum-resin exudates of Commiphora mukul) following the conditions prescribed in the parent drug stability testing guideline (Q1AR) issued by International Conference on Harmonization (ICH) [9].

Associations of Drug Stability with chemical compounds


Gene context of Drug Stability

  • High affinity binding of TCs with BSA signifies drug stability [15].
  • Free and encapsulated CPA was incubated in human blood and the drug stability was analyzed [16].
  • This small group of the most preferred antioxidants can then be employed in a conventional drug stability study thereby providing a rapid approach for the selection of the most suitable antioxidant for a pharmaceutical formulation [17].

Analytical, diagnostic and therapeutic context of Drug Stability


  1. Modulation of growth and radiochemosensitivity of human malignant glioma cells by acidosis. Reichert, M., Steinbach, J.P., Supra, P., Weller, M. Cancer (2002) [Pubmed]
  2. Microwave continuous sterilization of injection ampoules. Sasaki, K., Honda, W., Shimizu, K., Iizima, K., Ehara, T., Okuzawa, K., Miyake, Y. PDA journal of pharmaceutical science and technology / PDA. (1996) [Pubmed]
  3. The structural basis of camptothecin interactions with human serum albumin: impact on drug stability. Burke, T.G., Mi, Z. J. Med. Chem. (1994) [Pubmed]
  4. Bisantrene solubility and skin toxicity studies: efficacy of sodium bicarbonate as a local ulceration antidote. Dorr, R.T., Peng, Y.M., Alberts, D.S. Investigational new drugs. (1984) [Pubmed]
  5. Use of Monte Carlo simulation to design an optimized pharmacodynamic dosing strategy for meropenem. Kuti, J.L., Dandekar, P.K., Nightingale, C.H., Nicolau, D.P. Journal of clinical pharmacology. (2003) [Pubmed]
  6. Transdermal delivery of dideoxynucleoside-type anti-HIV drugs. 1. Stability studies for hairless rat skin permeation. Kim, D.D., Chien, Y.W. Journal of pharmaceutical sciences. (1995) [Pubmed]
  7. Stability of batanopride hydrochloride in aqueous solutions. Nassar, M.N., House, C.A., Agharkar, S.N. Journal of pharmaceutical sciences. (1992) [Pubmed]
  8. Formulation factors in preparing BTM-chitosan microspheres by spray drying method. Huang, Y., Yeh, M., Chiang, C. International journal of pharmaceutics. (2002) [Pubmed]
  9. HPTLC method for guggulsterone. II. Stress degradation studies on guggulsterone. Agrawal, H., Kaul, N., Paradkar, A.R., Mahadik, K.R. Journal of pharmaceutical and biomedical analysis. (2004) [Pubmed]
  10. Micro-method for the determination of roxithromycin in human plasma and urine by high-performance liquid chromatography using electrochemical detection. Demotes-Mainaird, F.M., Vinçon, G.A., Jarry, C.H., Albin, H.C. J. Chromatogr. (1989) [Pubmed]
  11. Micellar modification of drug stability: analysis of the effect of hexadecyltrimethylammonium halides on the rate of degradation of cephaclor. Oliveira, A.G., Cuccovia, I.M., Chaimovich, H. Journal of pharmaceutical sciences. (1990) [Pubmed]
  12. Skin permeation of different steroid hormones from polymeric coated liposomal formulations. Biruss, B., Valenta, C. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V. (2006) [Pubmed]
  13. Microparticles derived from marine sponge collagen (SCMPs): preparation, characterization and suitability for dermal delivery of all-trans retinol. Swatschek, D., Schatton, W., Müller, W., Kreuter, J. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V. (2002) [Pubmed]
  14. Dipeptide-based highly potent doxorubicin antibody conjugates. Jeffrey, S.C., Nguyen, M.T., Andreyka, J.B., Meyer, D.L., Doronina, S.O., Senter, P.D. Bioorg. Med. Chem. Lett. (2006) [Pubmed]
  15. Differential binding of tetracyclines with serum albumin and induced structural alterations in drug-bound protein. Khan, M.A., Muzammil, S., Musarrat, J. Int. J. Biol. Macromol. (2002) [Pubmed]
  16. Poly(lactic acid) microspheres for the sustained release of antiischemic agents. Dalpiaz, A., Scatturin, A., Pavan, B., Biondi, C., Vandelli, M.A., Forni, F. International journal of pharmaceutics. (2002) [Pubmed]
  17. Rapid screening of antioxidants in pharmaceutical formulation development using cyclic voltammetry--potential and limitations. Huang, T., Gao, P., Hageman, M.J. Current drug discovery technologies. (2004) [Pubmed]
  18. Internal morphology of poly(D,L-lactide-co-glycolide) BCNU-loaded microspheres. Influence on drug stability. Painbeni, T., Venier-Julienne, M.C., Benoit, J.P. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V. (1998) [Pubmed]
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