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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Nafamostat mesilate induces production of interleukin-12 and -18 in human peripheral blood mononuclear cells.

Little has been reported on the drugs inducing production of monocyte-derived cytokines like interleukin (IL)-18 and IL-12. We found that nafamostat mesilate elicits IL-12, IL-18, tumor necrosis factor-alpha and interferon-gamma production, and the expression of intercellular adhesion molecules-1, B7.1, B7.2, CD40, and CD40 ligand in human peripheral blood mononuclear cells. The cytokine production and adhesion molecule expression were abolished by anti-IL-12 and IL-18 antibodies. Therefore, IL-18 and IL-12 may play roles in the significant and immediate effects of nafamostat mesilate.[1]

References

  1. Nafamostat mesilate induces production of interleukin-12 and -18 in human peripheral blood mononuclear cells. Katsuno, G., Takahashi, H.K., Iwagaki, H., Mizuno, K., Mori, S., Yoshino, T., Nishibori, M., Tanaka, N. J. Pharmacol. Sci. (2005) [Pubmed]
 
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