Gene Review:
CD40 - CD40 molecule, TNF receptor superfamily...
Homo sapiens
Synonyms:
B-cell surface antigen CD40, Bp50, CD40L receptor, CDW40, CDw40, ...
- The CD40 antigen and its ligand. Banchereau, J., Bazan, F., Blanchard, D., Brière, F., Galizzi, J.P., van Kooten, C., Liu, Y.J., Rousset, F., Saeland, S. Annu. Rev. Immunol. (1994)
- Correspondence re R. Lapointe et al., CD40-stimulated B lymphocytes pulsed with tumor antigens are effective antigen-presenting cells that can generate specific T cells. Cancer Res 2003;63:2836-43. von Bergwelt-Baildon, M., Schultze, J.L., Maecker, B., Menezes, I., Nadler, L.M. Cancer. Res. (2004)
- The role of CD40 and CD80 accessory cell molecules in dendritic cell-dependent HIV-1 infection. Pinchuk, L.M., Polacino, P.S., Agy, M.B., Klaus, S.J., Clark, E.A. Immunity (1994)
- Human non-germinal center B cell interleukin (IL)-12 production is primarily regulated by T cell signals CD40 ligand, interferon gamma, and IL-10: role of B cells in the maintenance of T cell responses. Schultze, J.L., Michalak, S., Lowne, J., Wong, A., Gilleece, M.H., Gribben, J.G., Nadler, L.M. J. Exp. Med. (1999)
- CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40. Alderson, M.R., Armitage, R.J., Tough, T.W., Strockbine, L., Fanslow, W.C., Spriggs, M.K. J. Exp. Med. (1993)
- Suppressor of cytokine signaling 1 inhibits cytokine induction of CD40 expression in macrophages. Wesemann, D.R., Dong, Y., O'Keefe, G.M., Nguyen, V.T., Benveniste, E.N. J. Immunol. (2002)
- Characterization and dynamics of aggresome formation by a cytosolic GFP-chimera. García-Mata, R., Bebök, Z., Sorscher, E.J., Sztul, E.S. J. Cell Biol. (1999)
- Role of nigral NFkappaB p50 and p65 subunit expression in haloperidol-induced neurotoxicity and stereotyped behavior in rats. Saldaña, M., Bonastre, M., Aguilar, E., Marin, C. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. (2006)
- CD40/CD154 interactions at the interface of tolerance and immunity. Quezada, S.A., Jarvinen, L.Z., Lind, E.F., Noelle, R.J. Annu. Rev. Immunol. (2004)
- CD40 and CD154 in cell-mediated immunity. Grewal, I.S., Flavell, R.A. Annu. Rev. Immunol. (1998)
- Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines. Fiumara, P., Snell, V., Li, Y., Mukhopadhyay, A., Younes, M., Gillenwater, A.M., Cabanillas, F., Aggarwal, B.B., Younes, A. Blood (2001)
- Germinal center-derived signals act with Bcl-2 to decrease apoptosis and increase clonogenicity of drug-treated human B lymphoma cells. Walker, A., Taylor, S.T., Hickman, J.A., Dive, C. Cancer Res. (1997)
- Viral replication-independent blockade of dendritic cell maturation and interleukin-12 production by human herpesvirus 6. Smith, A.P., Paolucci, C., Di Lullo, G., Burastero, S.E., Santoro, F., Lusso, P. J. Virol. (2005)
- Mechanisms controlling the human immunoglobulin E response: new directions in the therapy of allergic diseases. Leung, D.Y. Pediatr. Res. (1993)
- Suppression of autoreactive T-cell response to glycoprotein IIb/IIIa by blockade of CD40/CD154 interaction: implications for treatment of immune thrombocytopenic purpura. Kuwana, M., Kawakami, Y., Ikeda, Y. Blood (2003)
- Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells. Hanissian, S.H., Geha, R.S. Immunity (1997)
- C4b-binding protein (C4BP) activates B cells through the CD40 receptor. Brodeur, S.R., Angelini, F., Bacharier, L.B., Blom, A.M., Mizoguchi, E., Fujiwara, H., Plebani, A., Notarangelo, L.D., Dahlback, B., Tsitsikov, E., Geha, R.S. Immunity (2003)
- Induction of human IgE synthesis in B cells by mast cells and basophils. Gauchat, J.F., Henchoz, S., Mazzei, G., Aubry, J.P., Brunner, T., Blasey, H., Life, P., Talabot, D., Flores-Romo, L., Thompson, J. Nature (1993)
- CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Henn, V., Slupsky, J.R., Gräfe, M., Anagnostopoulos, I., Förster, R., Müller-Berghaus, G., Kroczek, R.A. Nature (1998)
- Functional interactions of T cells with endothelial cells: the role of CD40L-CD40-mediated signals. Yellin, M.J., Brett, J., Baum, D., Matsushima, A., Szabolcs, M., Stern, D., Chess, L. J. Exp. Med. (1995)
- Assembly and regulation of the CD40 receptor complex in human B cells. Kuhné, M.R., Robbins, M., Hambor, J.E., Mackey, M.F., Kosaka, Y., Nishimura, T., Gigley, J.P., Noelle, R.J., Calderhead, D.M. J. Exp. Med. (1997)
- Disodium cromoglycate inhibits S mu-->S epsilon deletional switch recombination and IgE synthesis in human B cells. Loh, R.K., Jabara, H.H., Geha, R.S. J. Exp. Med. (1994)
- An essential role for Bruton's [corrected] tyrosine kinase in the regulation of B-cell apoptosis. Anderson, J.S., Teutsch, M., Dong, Z., Wortis, H.H. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Inhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosis. Kater, A.P., Dicker, F., Mangiola, M., Welsh, K., Houghten, R., Ostresh, J., Nefzi, A., Reed, J.C., Pinilla, C., Kipps, T.J. Blood (2005)
- CD40 ligand-mediated activation of the de novo RelB NF-kappaB synthesis pathway in transformed B cells promotes rescue from apoptosis. Mineva, N.D., Rothstein, T.L., Meyers, J.A., Lerner, A., Sonenshein, G.E. J. Biol. Chem. (2007)
- Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40. Tsukamoto, N., Kobayashi, N., Azuma, S., Yamamoto, T., Inoue, J. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Cutting edge: contrasting roles of TNF receptor-associated factor 2 (TRAF2) and TRAF3 in CD40-activated B lymphocyte differentiation. Hostager, B.S., Bishop, G.A. J. Immunol. (1999)
- A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40. Sato, T., Irie, S., Reed, J.C. FEBS Lett. (1995)
- Characterization of a CD40-dominant inhibitory receptor mutant. Mehl, A.M., Jones, M., Rowe, M., Brennan, P. J. Immunol. (2001)
- A Salmonella typhi OmpC fusion protein expressing the CD154 Trp140-Ser149 amino acid strand binds CD40 and activates a lymphoma B-cell line. Vega, M.I., Santos-Argumedo, L., Huerta-Yepez, S., Luría-Perez, R., Ortiz-Navarrete, V., Isibasi, A., González-Bonilla, C.R. Immunology (2003)
- Membrane-anchored CD40 is processed by the tumor necrosis factor-alpha-converting enzyme. Implications for CD40 signaling. Contin, C., Pitard, V., Itai, T., Nagata, S., Moreau, J.F., Déchanet-Merville, J. J. Biol. Chem. (2003)
- Molecular cloning of the human B cell CD20 receptor predicts a hydrophobic protein with multiple transmembrane domains. Einfeld, D.A., Brown, J.P., Valentine, M.A., Clark, E.A., Ledbetter, J.A. EMBO J. (1988)
- Conformational changes induced by DNA binding of NF-kappa B. Matthews, J.R., Nicholson, J., Jaffray, E., Kelly, S.M., Price, N.C., Hay, R.T. Nucleic Acids Res. (1995)
- Role of monocyte chemotactic protein-1 and nuclear factor kappa B in the pathogenesis of proliferative diabetic retinopathy. Harada, C., Okumura, A., Namekata, K., Nakamura, K., Mitamura, Y., Ohguro, H., Harada, T. Diabetes Res. Clin. Pract. (2006)
- Activation of human dendritic cells through CD40 cross-linking. Caux, C., Massacrier, C., Vanbervliet, B., Dubois, B., Van Kooten, C., Durand, I., Banchereau, J. J. Exp. Med. (1994)
- Interleukin-10 induces immunoglobulin G isotype switch recombination in human CD40-activated naive B lymphocytes. Malisan, F., Brière, F., Bridon, J.M., Harindranath, N., Mills, F.C., Max, E.E., Banchereau, J., Martinez-Valdez, H. J. Exp. Med. (1996)
- CD40 activation induces p53-dependent vascular endothelial growth factor secretion in human multiple myeloma cells. Tai, Y.T., Podar, K., Gupta, D., Lin, B., Young, G., Akiyama, M., Anderson, K.C. Blood (2002)
- Tumor necrosis factor receptor-associated factor (TRAF) 1 regulates CD40-induced TRAF2-mediated NF-kappaB activation. Fotin-Mleczek, M., Henkler, F., Hausser, A., Glauner, H., Samel, D., Graness, A., Scheurich, P., Mauri, D., Wajant, H. J. Biol. Chem. (2004)
- Characterization of the roles of TNF receptor-associated factor 6 in CD40-mediated B lymphocyte effector functions. Jalukar, S.V., Hostager, B.S., Bishop, G.A. J. Immunol. (2000)
- Blockade of T lymphocyte costimulation with cytotoxic T lymphocyte-associated antigen 4-immunoglobulin (CTLA4Ig) reverses the cellular pathology of psoriatic plaques, including the activation of keratinocytes, dendritic cells, and endothelial cells. Abrams, J.R., Kelley, S.L., Hayes, E., Kikuchi, T., Brown, M.J., Kang, S., Lebwohl, M.G., Guzzo, C.A., Jegasothy, B.V., Linsley, P.S., Krueger, J.G. J. Exp. Med. (2000)
- Characteristics of intestinal dendritic cells in inflammatory bowel diseases. Hart, A.L., Al-Hassi, H.O., Rigby, R.J., Bell, S.J., Emmanuel, A.V., Knight, S.C., Kamm, M.A., Stagg, A.J. Gastroenterology (2005)
- TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs. Hauer, J., Püschner, S., Ramakrishnan, P., Simon, U., Bongers, M., Federle, C., Engelmann, H. Proc. Natl. Acad. Sci. U.S.A. (2005)
- CD40 activation induces apoptosis in cultured human hepatocytes via induction of cell surface fas ligand expression and amplifies fas-mediated hepatocyte death during allograft rejection. Afford, S.C., Randhawa, S., Eliopoulos, A.G., Hubscher, S.G., Young, L.S., Adams, D.H. J. Exp. Med. (1999)
- B cell activation via CD40 is required for specific antibody production by antigen-stimulated human B cells. Nonoyama, S., Hollenbaugh, D., Aruffo, A., Ledbetter, J.A., Ochs, H.D. J. Exp. Med. (1993)
- The effects of malignant transformation on susceptibility of human urothelial cells to CD40-mediated apoptosis. Bugajska, U., Georgopoulos, N.T., Southgate, J., Johnson, P.W., Graber, P., Gordon, J., Selby, P.J., Trejdosiewicz, L.K. J. Natl. Cancer Inst. (2002)